ArticleFrontiers in immunology2023
Mass cytometric analysis unveils a disease-specific immune cell network in the bone marrow in acquired aplastic anemia.
Article in Frontiers in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 4 citations in OpenAlex.
- Selective lymphodepletion underlies the efficacy of horse anti-thymocyte globulin-based immunosuppressive therapy in aplastic anemia.Haematologica · 2026Article
- Perioperative safety of emergency ovarian tissue cryopreservation for fertility preservation in hematological patients prior to hematopoietic stem cell transplantation.Journal of assisted reproduction and genetics · 2026Article
- Mass cytometry analysis reveals a cross-tissue immune landscape inMicrobiology spectrum · 2025Article
- Targeting interleukin-2-inducible T cell kinase ameliorates immune-mediated aplastic anemia.Cancer immunology, immunotherapy : CII · 2025Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
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Abstract
Idiopathic acquired aplastic anemia (AA) is considered an immune-mediated syndrome of bone marrow failure since approximately 70% of patients respond to immunosuppressive therapy (IST) consisting of a course of anti-thymocyte globulin (ATG) followed by long-term use of ciclosporin. However, the immune response that underlies the pathogenesis of AA remains poorly understood. In this study, we applied high-dimensional mass cytometry on bone marrow aspirates of AA patients pre-ATG, AA patients post-ATG and healthy donors to decipher which immune cells may be implicated in the pathogenesis of AA. We show that the bone marrow of AA patients features an immune cell composition distinct from healthy donors, with significant differences in the myeloid, B-cell, CD4
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