ReviewJournal of orthopaedic translation2023
Choosing the right animal model for osteomyelitis research: Considerations and challenges.
Review in Journal of orthopaedic translation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- A multiscale pathoanatomical atlas guides the design of functionally graded, anatomically intelligent implants for chronic osteomyelitis.Bioactive materials · 2026Article
- A novel mouse calvarial defect model of osteomyelitis induced by Staphylococcus aureus (ATCC 6538).Laboratory animal research · 2026Article
- Current and emerging biomaterials for targeted drug delivery in osteomyelitis management.Discover nano · 2026Review
- Isolation and Characterization of Meniscus Progenitor Cells From Rat, Rabbit, Goat, and Human.Cartilage · 2026Article
- ISO-1 sustained-release hydrogel repairs infected bone defects by suppressing osteoblast pyroptosis and enhancing osteogenic differentiation via the MIF-CD74/PI3K/AKT signaling pathway.Materials today. Bio · 2026Article
- Formulation-Dependent Antibacterial Performance: Design and Biomedical Applications.Gels (Basel, Switzerland) · 2026Review
- Osteomyelitis related lameness across animal species: pathophysiology, etiology, epidemiology and experimental model approaches.Frontiers in veterinary science · 2026Review
- Context-dependent roles of the NLRP3 inflammasome in osteomyelitis and strategies for precision modulation.Frontiers in immunology · 2026Review
- Feasibility of a rat femoral-defect model for immediate perioperative and delayed post-implantation implant-associated bone infections.Journal of bone and joint infection · 2026Article
- Establishment of a clinically relevant beagle model for periprosthetic joint infection with 3D-printed prostheses and multimodal evaluation.Journal of orthopaedic translation · 2025Article
- Animal Models of Orthopedic Implant-Associated Infections and Revisions.ACS biomaterials science & engineering · 2025Review
- Application of Antimicrobial Peptides (AMPs) in Treatment of Osteomyelitis in Human and Veterinary Orthopedics.Journal of functional biomaterials · 2025Review
- Antimicrobial photodynamic therapy with 5-aminolevulinic acid plus antibiotics: a promising treatment for tibial osteomyelitis caused by drug-resistant bacteria.Frontiers in pharmacology · 2025Article
- Evaluation of effects of vancomycin/polycaprolactone nanocomposite in comparison with curcumin/polycaprolactone on the healing of experimental osteomyelitis in rabbit tibia.Veterinary research forum : an international quarterly journal · 2025Article
- Integrative gene expression analysis and animal model reveal immune- and autophagy-related biomarkers in osteomyelitis.Immunity, inflammation and disease · 2024Article
- Repairing, reconstructing, and recovering after COVID-19.Journal of orthopaedic translation · 2023Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteomyelitis is a debilitating bone disorder characterized by an inflammatory process involving the bone marrow, bone cortex, periosteum, and surrounding soft tissue, which can ultimately result in bone destruction. The etiology of osteomyelitis can be infectious, caused by various microorganisms, or noninfectious, such as chronic nonbacterial osteomyelitis (CNO) and chronic recurrent multifocal osteomyelitis (CRMO). Researchers have turned to animal models to study the pathophysiology of osteomyelitis. However, selecting an appropriate animal model that accurately recapitulates the human pathology of osteomyelitis while controlling for multiple variables that influence different clinical presentations remains a significant challenge. In this review, we present an overview of various animal models used in osteomyelitis research, including rodent, rabbit, avian/chicken, porcine, minipig, canine, sheep, and goat models. We discuss the characteristics of each animal model and the corresponding clinical scenarios that can provide a basic rationale for experimental selection. This review highlights the importance of selecting an appropriate animal model for osteomyelitis research to improve the accuracy of the results and facilitate the development of novel treatment and management strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.