ArticleAlzheimer's & dementia (New York, N. Y.)
Effects of informant replacement in Alzheimer's disease clinical trials.
Article in Alzheimer's & dementia (New York, N. Y.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Study partner profile effects on CDR-SB change in anti-amyloid therapy evaluation.medRxiv : the preprint server for health sciences · 2026Article
- Effects of informant replacement in Alzheimer's disease clinical trials.Alzheimer's & dementia (New York, N. Y.)Article
- Impact of study partner replacement in a mild cognitive impairment clinical trial.Alzheimer's & dementia (New York, N. Y.)Article
- Impacts of informant replacement in two industry-sponsored Alzheimer's disease clinical trials.Alzheimer's & dementia (New York, N. Y.)Article
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Authors and funding
4 authors.
Funding
Abstract
introductionAlzheimer's disease (AD) trials require enrollment with an informant.
methodsWe assessed relationships between informant replacement and Alzheimer's Disease Cooperative Study Activities of Daily Living (ADCS-ADL) scores across four AD trials. Using generalized estimating equations, we examined associations between replacement and change in ADCS-ADL between successive visits. We used analysis of covariance to estimate the association between replacement and 18-month change from baseline, and an
resultsAmong 1336 participants, 63 (≈5%) experienced replacement. Between-visit mean change in ADCS-ADL was 2.44 points lower comparing replacement to stable informants (95% confidence interval [CI]: -3.91, -0.98). The difference in between-visit mean absolute change was 2.38 points (95% CI: 1.24, 3.52). Replacement was not significantly associated with an 18-month change from baseline. The ratio of variances (replacement/stable) was 1.80 (95% CI: 1.19, 2.99). DISCUSSION: Informant replacement is associated with bias and increased variability between visits and increased variance for overall ADCS-ADL.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.