ArticleAnnals of clinical and translational neurology2024
Correlation of slow-wave sleep with motor and nonmotor progression in Parkinson's disease.
Article in Annals of clinical and translational neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Enhancing sleep slow waves with auditory stimulation in people with Parkinson's disease: a randomized proof-of-concept trial.Scientific reports · 2026Trial
- Personalized supervised and unsupervised intracranial sleep decoding during deep brain stimulation.NPJ digital medicine · 2026Article
- Evaluation of glymphatic system activity and lateralization by diffusion tensor imaging in Parkinson's disease with excessive daytime sleepiness.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Butyrate improves abnormal sleep architecture in a Parkinson's disease mouse model via BDNF/TrkB signaling.NPJ Parkinson's disease · 2025Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
objectiveThis study aimed to explore the association between slow-wave sleep and the progression of motor and nonmotor symptoms in patients with PD.
methodsData were collected from the Parkinson's Progression Markers Initiative study. Slow-wave sleep, also known as deep non-rapid eye movement (DNREM) sleep, was objectively assessed using the Verily Study Watch. Motor function was assessed using the Movement Disorder Society-Unified Parkinson's Disease Rating Scale Part III score, Hoehn and Yahr stage, freezing of gait, motor fluctuations, and dyskinesia severity. Comprehensive assessments were conducted on nonmotor symptoms, including depression, anxiety, global cognitive function, and autonomic dysfunction. Statistical analyses involved repeated-measures analysis of variance and linear regression.
resultsA total of 102 patients with PD were included in the study, with a median follow-up duration of 3.4 years. In the long DNREM sleep duration group (n = 55), better motor function (DNREM × time interaction: F
interpretationThe findings suggest an association between longer DNREM sleep duration and slower motor and nonmotor progression in patients with PD.
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Registered trials
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