ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2024
Cognitively defined Alzheimer's dementia subgroups have distinct atrophy patterns.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- AI-based multimodal integration of genomics and electronic health records.Nature reviews. Genetics · 2026Review
- The Visual System in Alzheimer's Disease: A Multilevel Review of Pathology, Monitoring, and Intervention.Vision (Basel, Switzerland) · 2026Review
- Comparative evaluation of automated MRI-based brain volumetry software for estimating cognitive domains in early Alzheimer's disease.BMC medical imaging · 2026Article
- Engineering Extracellular Vesicles for Anti-Aging Therapy: Mechanisms, Applications, and Perspectives.Aging cell · 2026Review
- Contributions of the Alzheimer's Disease Neuroimaging Initiative to advancing AD research: a targeted review of recent publications.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Cholinergic Basal Forebrain Atrophy Accelerates Cognitive Decline via Cortical Thinning: The Moderating Role of Amyloid-β Pathology in Preclinical Alzheimer's Disease.Research square · 2026Article
- Heterogeneous patterns of cognitive decline in Alzheimer's disease across three domains of cognition.Journal of Alzheimer's disease : JAD · 2026Article
- Structural changes in gray matter and white matter across the Alzheimer's disease continuum.Frontiers in neuroscience · 2026Article
- Hierarchical-circular model of biological memory: a multilevel hypothesis for pathogenesis and allostatic integrity in Alzheimer's disease and related dementias.Frontiers in dementia · 2026Article
- Persistent Alzheimer-related molecular dysregulation after cerebral ischemia: a hierarchical-circular hypothesis of impaired allostatic recovery.Frontiers in aging neuroscience · 2026Article
- Neurofibrillary tangle distribution in posterior cortical atrophy and typical early-onset Alzheimer's Disease.Free neuropathology · 2026Article
- Epigenetic memory and allostatic integrity: a theoretical integration of the hierarchical-circular model using a longitudinal methylation signature of dementia.Frontiers in aging neuroscience · 2026Article
- Cholinergic basal forebrain atrophy accelerates cognitive decline via cortical thinning: The moderating role of amyloid-β pathology in preclinical Alzheimer's disease.The journal of prevention of Alzheimer's disease · 2025Article
- Facets of language performance in early-onset and late-onset Alzheimer's disease dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Facets of language performance in early-onset and late-onset Alzheimer's disease dementia.medRxiv : the preprint server for health sciences · 2025Article
- Association of birthweight and risk of incident dementia: a prospective cohort study.GeroScience · 2024Article
- Cognitively defined Alzheimer's dementia subgroups have distinct atrophy patterns.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Ten-words recall test: an effective tool to differentiate mild cognitive impairment from subjective cognitive decline.Frontiers in psychiatry · 2024Article
- Prefrontal cortex activation patterns in age-related cognitive decline: insights from verbal fluency task.Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
17 authors.
Funding
Abstract
introductionWe sought to determine structural magnetic resonance imaging (MRI) characteristics across subgroups defined based on relative cognitive domain impairments using data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) and to compare cognitively defined to imaging-defined subgroups.
methodsWe used data from 584 people with Alzheimer's disease (AD) (461 amyloid positive, 123 unknown amyloid status) and 118 amyloid-negative controls. We used voxel-based morphometry to compare gray matter volume (GMV) for each group compared to controls and to AD-Memory.
resultsThere was pronounced bilateral lower medial temporal lobe atrophy with relative cortical sparing for AD-Memory, lower left hemisphere GMV for AD-Language, anterior lower GMV for AD-Executive, and posterior lower GMV for AD-Visuospatial. Formal asymmetry comparisons showed substantially more asymmetry in the AD-Language group than any other group (p = 1.15 × 10 DISCUSSION: MRI findings differ across cognitively defined AD subgroups.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.