Evidence map›Paper›PMID 38093478›Full record

ArticleBritish journal of haematology2024

Blood pressure thresholds for the diagnosis of hypertensive disorders of pregnancy in sickle cell disease.

Macy L Early, Maidah Raja, Amy Luo, Marissa Solow, Kristine Matusiak, Ahizechukwu C Eke, Nadine Shehata, Kevin H M Kuo, Sophie Lanzkron, Ann Kinga Malinowski and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of haematology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Proactive management to improve outcomes of high-risk pregnancy in people with sickle cell disease.Hematology. American Society of Hematology. Education Program · 2025
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Macy L EarlyDivision of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Maidah RajaDivision of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Amy LuoDivision of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Marissa SolowDivision of Haematology, Department of Medicine, University Health Network, Toronto, Ontario, Canada.
Kristine MatusiakDivision of Haematology, Department of Medicine, University Health Network, Toronto, Ontario, Canada.
Ahizechukwu C EkeDivision of Maternal-Fetal Medicine & Clinical Pharmacology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Nadine ShehataDivision of Hematology, Sinai Health System, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
Kevin H M KuoDivision of Haematology, Department of Medicine, University Health Network, Toronto, Ontario, Canada.ORCID 0000-0002-6744-9238
Sophie LanzkronDivision of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Ann Kinga MalinowskiDivision of Hematology, Sinai Health System, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
Lydia H PeckerDivision of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-8371-9752
Johns Hopkins University · USUniversity Health Network · CAUniversity of Toronto · CA

Funding

Clinical and genetic risk factors associated with adverse long-term health outcomes after curative therapies in individuals with sickle cell diseaseU01HL156620 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DEBAUN, MICHAEL R., FITZHUGH, COURTNEY D · 2021 to 2025
$4.1M
Integrating data for causal inference in behavioral healthT32MH122357 · NIMH · JOHNS HOPKINS UNIVERSITY · PI Rashelle Jean Musci, Elizabeth A. Stuart · 2020 to 2026
$1.8M
OVARIAN RESERVE IN POST-MENARCHAL FEMALES WITH SICKLE CELL ANEMIAK23HL146841 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI PECKER, LYDIA · 2020 to 2024
$1.2M
Doris Duke Charitable Foundation #2020147NHLBI NIH HHS K23 HL146841NHLBI NIH HHS U01 HL156620NIMH NIH HHS T32 MH122357
6 · The paper itself

Abstract

In this retrospective cohort study of singleton pregnancies in people with sickle cell disease (SCD) delivered at two academic centres between 1990 and 2021, we collected demographic and SCD-related data, pregnancy outcomes, and the highest systolic and diastolic blood pressure (SBP and DBP) at seven time periods. We compared the characteristics of subjects with new or worsening proteinuria (NWP) during pregnancy to those without. We then constructed receiver operating characteristic (ROC) curves to determine the blood pressure (BP) that best identifies those with NWP. The SBP or DBP thresholds which maximized sensitivity and specificity were 120 mmHg SBP (sensitivity: 55.2%, specificity: 73.5%) and 70 mmHg DBP (sensitivity: 27.6%, specificity: 67.7%). The existing BP threshold of 140/90 mmHg lacked sensitivity in both genotype groups (HbSS/HbSβ

Indexed as

Anemia, Sickle CellHypertensionHypertension, Pregnancy-InducedPre-EclampsiaBlood PressureFemaleHumansPregnancyRetrospective Studiesblood pressurehypertensive disorders of pregnancypregnancysickle cell disease

Identifiers

PMID38093478
PMCPMC10939908
OpenAlexW4389742255

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.