ArticleVeterinary research2023
Protective efficacy of multiepitope vaccines constructed from common antigens of Eimeria species in chickens.
Article in Veterinary research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 12 citations in OpenAlex.
- Review on anticoccidial vaccine development for chickens: Past progress, modern methods, and production bottlenecks.Poultry science · 2026Review
- Evaluation of immune protective efficacy of recombinant subunit vaccines based on Eimeria tenella EtAMA1 and EtSAG13.Poultry science · 2026Article
- Nanotechnology-Enabled Approaches in Poultry Coccidiosis Management: Advances, Challenges, and Future Perspectives.Poultry science · 2026Review
- A yeast-based oral vaccine platform reveals antigen-dependent protection against Eimeria tenella.Poultry science · 2026Article
- Genetic diversity inVeterinary world · 2026Review
- UnderstandingFrontiers in cellular and infection microbiology · 2026Review
- Proteomic analysis and functional characterization of excretory-secretory products from adult Toxocara canis: insights into parasite-host interactions.BMC genomics · 2025Article
- Harnessing bioinformatics and recombinant technology to combat avian coccidiosis: A 19-kDa sporozoite protein-based vaccine.Open veterinary journal · 2025Article
- Knockdown of annexin A2 enhances the host cell apoptosis induced byFrontiers in veterinary science · 2025Article
- Identification of highly cross-reactive immunogens in Eimeria tenella sporozoites.Parasite (Paris, France) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Clinical avian coccidiosis is typically caused by coinfection with several Eimeria species. Recombinant protein and DNA vaccines have shown promise in controlling coccidiosis. On this basis, DNA vaccines that encode multiple epitopes from different Eimeria species may provide broad protection against coinfections. In this study, we designed a fusion gene fragment, 14EGT, that contained concentrated T-cell epitopes from four common antigens of Eimeria species (14-3-3, elongation factor 2, glyceraldehyde-3-phosphate dehydrogenase, and transhydrogenase). The multiepitope DNA vaccine pVAX1-14EGT and recombinant protein vaccine pET-32a-14EGT (r14EGT) were then created based on the 14EGT fragment. Subsequently, cellular and humoral immune responses were measured in vaccinated chickens. Vaccination-challenge trials were also conducted, where the birds were vaccinated with the 14EGT preparations and later exposed to single or multiple Eimeria species to evaluate the protective efficacy of the vaccines. According to the results, vaccination with 14EGT preparations effectively increased the proportions of CD4
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.