Evidence map›Paper›PMID 38093313›Full record

ArticleMicrobial cell factories2023

PAS domain containing regulator SLCG_7083 involved in morphological development and glucose utilization in Streptomyces lincolnensis.

Chun-Yan Lin, Yixian Ru, Yanchao Jin, Qi Lin, Guang-Rong Zhao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbial cell factories, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Chun-Yan LinCollege of Materials and Chemical Engineering, Minjiang University, Fuzhou, 350108, China.
Yixian RuCollege of Materials and Chemical Engineering, Minjiang University, Fuzhou, 350108, China.
Yanchao JinCollege of Environmental and Resource Sciences, Fujian Normal University, Fuzhou, Fujian, 350117, China.
Qi LinCollege of Materials and Chemical Engineering, Minjiang University, Fuzhou, 350108, China. qlin1990@163.com.
Guang-Rong ZhaoFrontier Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering (Ministry of Education), School of Chemical Engineering and Technology, Tianjin University, Yaguan Road 135, Jinnan District, Tianjin, 300350, China. grzhao@tju.edu.cn.
Minjiang University · CNCollaborative Innovation Center of Chemical Science and Engineering Tianjin · CNFujian Normal University · CN

Funding

Natural Science Foundation of Fujian Province, China 2021J011026Research and Development Program in Key Areas of Guangdong Province, China 2020B0303070002
6 · The paper itself

Abstract

backgroundStreptomyces lincolnensis is well known for producing the clinically important antimicrobial agent lincomycin. The synthetic and regulatory mechanisms on lincomycin biosynthesis have been deeply explored in recent years. However, the regulation involved in primary metabolism have not been fully addressed.

resultsSLCG_7083 protein contains a Per-Arnt-Sim (PAS) domain at the N-terminus, whose homologous proteins are highly distributed in Streptomyces. The inactivation of the SLCG_7083 gene indicated that SLCG_7083 promotes glucose utilization, slows mycelial growth and affects sporulation in S. lincolnensis. Comparative transcriptomic analysis further revealed that SLCG_7083 represses eight genes involved in sporulation, cell division and lipid metabolism, and activates two genes involved in carbon metabolism.

conclusionsSLCG_7083 is a PAS domain-containing regulator on morphological development and glucose utilization in S. lincolnensis. Our results first revealed the regulatory function of SLCG_7083, and shed new light on the transcriptional effects of SLCG_7083-like family proteins in Streptomyces.

Indexed as

Bacterial ProteinsStreptomycesGene Expression Regulation, BacterialLincomycinTranscription FactorsBacterial ProteinsLincomycinTranscription FactorsGlucose utilizationMorphological developmentPAS domainStreptomyces lincolnensisTranscriptional regulator

Identifiers

PMID38093313
PMCPMC10717218
OpenAlexW4389681046

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.