ArticleJournal of neuroengineering and rehabilitation2023
The impact of lesion side on bilateral upper limb coordination after stroke.
Article in Journal of neuroengineering and rehabilitation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A bibliometric analysis of electroencephalogram research in stroke: current trends and future directions.Frontiers in neurology · 2025Pooled it
- Impact of motor anxiety on rehabilitation in elderly stroke patients: A retrospective study.World journal of psychiatry · 2026Article
- Associations between upper limb flexibility and all-cause mortality in the oldest-old.Journal of global health · 2025Article
- Simplified assessment of upper limb dysfunction after stroke: decision tree analysis based on the International Classification of Functioning, Disability and Health.European journal of physical and rehabilitation medicine · 2025Article
- Post-Stroke Rehabilitation: Neurophysiology Processes of Bilateral Movement Training and Interlimb Coupling-A Systematic Review.Journal of clinical medicine · 2025Review
- Brain temporal dynamics correlate with clinical traits, spontaneous arm movements, and recovery in middle cerebral artery stroke.Frontiers in human neuroscience · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA stroke frequently results in impaired performance of activities of daily life. Many of these are highly dependent on effective coordination between the two arms. In the context of bimanual movements, cyclic rhythmical bilateral arm coordination patterns can be classified into two fundamental modes: in-phase (bilateral homologous muscles contract simultaneously) and anti-phase (bilateral muscles contract alternately) movements. We aimed to investigate how patients with left (LHS) and right (RHS) hemispheric stroke are differentially affected in both individual-limb control and inter-limb coordination during bilateral movements.
methodsWe used kinematic measurements to assess bilateral coordination abilities of 18 chronic hemiparetic stroke patients (9 LHS; 9 RHS) and 18 age- and sex-matched controls. Using KINARM upper-limb exoskeleton system, we examined individual-limb control by quantifying trajectory variability in each hand and inter-limb coordination by computing the phase synchronization between hands during anti- and in-phase movements.
resultsRHS patients exhibited greater impairment in individual- and inter-limb control during anti-phase movements, whilst LHS patients showed greater impairment in individual-limb control during in-phase movements alone. However, LHS patients further showed a swap in hand dominance during in-phase movements.
conclusionsThe current study used individual-limb and inter-limb kinematic profiles and showed that bilateral movements are differently impaired in patients with left vs. right hemispheric strokes. Our results demonstrate that both fundamental bilateral coordination modes are differently controlled in both hemispheres using a lesion model approach. From a clinical perspective, we suggest that lesion side should be taken into account for more individually targeted bilateral coordination training strategies.
trial registrationthe current experiment is not a health care intervention study.
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