Evidence map›Paper›PMID 38093285›Full record

ArticleJournal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance2023

Regional quantification of cardiac metabolism with hyperpolarized [1-

Peder E Z Larson, Shuyu Tang, Xiaoxi Liu, Avantika Sinha, Nicholas Dwork, Sanjay Sivalokanathan, Jing Liu, Robert Bok, Karen G Ordovas, James Slater and 2 more

Open access · goldAbstract read
In one paragraph

Article in Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. [3-Npj imaging · 2026
    Article
  6. Article
  7. Article
  8. The mitochondrial lactate oxidation complex: endpoint for carbohydrate carbon disposal.American journal of physiology. Endocrinology and metabolism · 2025
    Article
  9. Review
  10. A pharmacokinetic model for hyperpolarizedMagnetic resonance in medicine · 2024
    Article
  11. Review
  12. Review
  13. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Peder E Z Larson *Department of Radiology and Biomedical Imaging, University of CA-San Francisco, 1700 4th Street, Byers Hall Room 102C, San Francisco, CA, 94143, USA. peder.larson@ucsf.edu.ORCID 0000-0003-4183-3634
Shuyu Tang *Department of Radiology and Biomedical Imaging, University of CA-San Francisco, 1700 4th Street, Byers Hall Room 102C, San Francisco, CA, 94143, USA.
Xiaoxi LiuDepartment of Radiology and Biomedical Imaging, University of CA-San Francisco, 1700 4th Street, Byers Hall Room 102C, San Francisco, CA, 94143, USA.
Avantika SinhaDepartment of Radiology and Biomedical Imaging, University of CA-San Francisco, 1700 4th Street, Byers Hall Room 102C, San Francisco, CA, 94143, USA.
Nicholas DworkDepartment of Radiology and Biomedical Imaging, University of CA-San Francisco, 1700 4th Street, Byers Hall Room 102C, San Francisco, CA, 94143, USA.
Sanjay SivalokanathanDivision of Internal Medicine, Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Jing LiuDepartment of Radiology and Biomedical Imaging, University of CA-San Francisco, 1700 4th Street, Byers Hall Room 102C, San Francisco, CA, 94143, USA.
Robert BokDepartment of Radiology and Biomedical Imaging, University of CA-San Francisco, 1700 4th Street, Byers Hall Room 102C, San Francisco, CA, 94143, USA.
Karen G OrdovasDepartment of Radiology and Biomedical Imaging, University of CA-San Francisco, 1700 4th Street, Byers Hall Room 102C, San Francisco, CA, 94143, USA.
James SlaterDepartment of Radiology and Biomedical Imaging, University of CA-San Francisco, 1700 4th Street, Byers Hall Room 102C, San Francisco, CA, 94143, USA.
Jeremy W GordonDepartment of Radiology and Biomedical Imaging, University of CA-San Francisco, 1700 4th Street, Byers Hall Room 102C, San Francisco, CA, 94143, USA.
M Roselle AbrahamCardiology Division, Department of Medicine, University of California-San Francisco, San Francisco, CA, USA.
University of California, San Francisco · USPalo Alto University · USUniversity of Colorado Denver · USUniversity of Pennsylvania · USUniversity of Washington · US

Funding

TR&D3: Open-Source Tools for Processing Hyperpolarized MR DataP41EB013598 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Daniel B Vigneron · 2011 to 2026
$19.9M
Preclinical imaging characterization and resource development of PDX SCNC prostate cancer murine modelsU24CA253377 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KURHANEWICZ, JOHN, PEEHL, DONNA M. · 2020 to 2024
$3.4M
Hyperpolarized Carbon-13 Metabolic MRI of the Human HeartR33HL161816 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ABRAHAM, MARIA ROSELLE, LARSON, PEDER ERIC ZUFALL · 2022 to 2023
$965k
NCI NIH HHS U24 CA253377NCI NIH HHS U24CA253377NHLBI NIH HHS R33 HL161816NHLBI NIH HHS R33HL161816NIBIB NIH HHS P41 EB013598NIBIB NIH HHS P41EB013598
6 · The paper itself

Abstract

backgroundThe heart has metabolic flexibility, which is influenced by fed/fasting states, and pathologies such as myocardial ischemia and hypertrophic cardiomyopathy (HCM). Hyperpolarized (HP)

methodsWe developed and applied methods for whole-heart imaging of

resultsWe demonstrate whole heart coverage for dynamic measurement of pyruvate-to-lactate conversion via LDH and pyruvate-to-bicarbonate conversion via PDH at a resolution of 6 × 6 × 21 mm

conclusionsWe demonstrate first-in-human regional quantifications of cardiac metabolism by HP

Indexed as

BicarbonatesPyruvic AcidCarbon IsotopesGlucoseHumansLactic AcidMagnetic Resonance ImagingPredictive Value of TestsBicarbonatesCarbon IsotopesGlucoseLactic AcidPyruvic Acid

Identifiers

PMID38093285
PMCPMC10720165
OpenAlexW4389704096

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.