ArticleCardiovascular diabetology2023
Triglyceride-glucose index is associated with a higher risk of stroke in a hypertensive population.
Article in Cardiovascular diabetology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association of triglyceride-glucose index and its related parameters with the risk of stroke: a meta-analysis.BMC neurology · 2025Pooled it
- Retrospective Cohort Analysis of TyG, TyG-SI, and TyG-Lac Indices as Predictors of 360-Day Mortality in Critically Ill Ischemic Stroke Patients.Journal of clinical medicine · 2026Article
- Joint associations of anthropometric indices and C-reactive protein-triglyceride-glucose index with incident hypertension: a stratified analysis by blood pressure level from the CHARLS, 2011-2020.Cardiovascular diabetology · 2026Article
- Blood-Brain Barrier Permeability Dynamics and Mediation of Triglyceride-Glucose Index on Acute Ischemic Stroke Outcomes.Journal of the American Heart Association · 2026Article
- Article
- The association between the C-reactive protein-triglyceride glucose index and myocardial injury after acute ischemic stroke: a machine learning analysis of the brain-heart axis.Frontiers in cardiovascular medicine · 2026Article
- Association of Insulin Resistance, Sarcopenia, and Risk of Cardiovascular Disease: Findings From the China Health and Retirement Longitudinal Study.JMIR aging · 2025Article
- Association between dynamic changes in the triglyceride-glucose index and prognosis in patients with acute ST-segment elevation myocardial infarction.Cardiovascular diabetology · 2025Article
- The triglyceride-glucose index: updating evidence from clinical settings to molecular mechanisms in ageing-related cerebrovascular diseases.Cardiovascular diabetology · 2025Review
- Triglyceride-Glucose Index Predicts Instability in the Natural History of Intracranial Aneurysms: Insights From a Large-Scale Chinese Multicenter Cohort.Journal of the American Heart Association · 2025Article
- Triglyceride-glucose index and cancer risk: a prospective cohort study in Taiwan.Diabetology & metabolic syndrome · 2025Article
- Impact of triglyceride glucose-weight adjusted waist index and its cumulative exposure on stroke risk: a nationwide prospective cohort study.Lipids in health and disease · 2025Article
- Inverse L-shaped association of triglyceride glucose index with all-cause and cerebral cardiovascular-related mortality in osteoarthritis patients: a cohort of 4145 patients.Clinical rheumatology · 2025Article
- Associations of the triglyceride-glucose index with mortality mediated by blood urea nitrogen among critically ill patients: a cohort study.Scientific reports · 2025Article
- Evaluation of the effects of short-term PMBMC cardiovascular disorders · 2025Article
- Application of TyG index and carotid ultrasound parameters in the prediction of ischemic stroke.Frontiers in endocrinology · 2025Article
- The predictive value of TyG index in patients with vertebrobasilar system thrombectomy.Frontiers in neurology · 2025Article
- C-reactive protein-triglyceride glucose index predicts stroke incidence in a hypertensive population: a national cohort study.Diabetology & metabolic syndrome · 2024Article
- Insulin resistance and sarcopenia: a prognostic longitudinal link to stroke risk in middle-aged and elderly Chinese population.BMC public health · 2024Article
- Triglyceride-Glucose Index as Predictor for Hypertension, CHD and STROKE Risk among Non-Diabetic Patients: A NHANES Cross-Sectional Study 2001-2020.Journal of epidemiology and global health · 2024Article
Corrections and comments
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7 authors.
Funding
Abstract
backgroundThis study aimed to evaluate the association of triglyceride-glucose (TyG) index, an insulin resistance surrogate biomarker, with first stroke in a hypertensive population and to explore potential influencing factors.
methodsThis study, a cohort study among a rural Chinese hypertensive population, utilized data from the China Stroke Primary Prevention Trial (CSPPT). The TyG index was calculated as ln [fasting triglyceride (mg/dL) × fasting glucose (mg/dL)/2]. Multivariate analysis using Cox proportional hazards models was conducted.
resultsA total of 7569 hypertensive patients were included in this study. When TyG index was assessed as quartiles, compared with the reference group (Quartile 1), the hazard ratio of stroke was 1.04 in Quartile 2, 1.43 in Quartile 3, and 1.45 in Quartile 4, with a significant trend test (P = 0.013). When Quartiles 3 and 4 were combined (≥ 8.8), the hazard ratio was 1.41 compared with combined Quartiles 1 and 2 (< 8.8). Similar findings were observed for the association of TyG index with ischemic stroke. Further, a joint effect of baseline TyG index and age on first stroke was found. Using the group with TyG < 8.8 and age < 60 years as a reference, the highest hazard ratio of stroke was found in the group with a higher TyG index and aged 60 or greater (HR: 2.15, 95% CI 1.50, 3.07, P < 0.001).
conclusionsIn a hypertensive population, baseline TyG index was associated with a significantly higher risk of first stroke. In addition, age was a significant effect modifier for this association.
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