ArticleBMC medicine2023
Exploring multimorbidity profiles in middle-aged inpatients: a network-based comparative study of China and the United Kingdom.
Article in BMC medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Risk prediction models for mortality in patients with multimorbidity: a systematic review and meta-analysis.Frontiers in public health · 2025Pooled it
- Longitudinal Patterns of Within- and Cross-Domain Multimorbidity Across Physical, Psychological, and Cognitive Conditions in China and the United States: The Role of Socioeconomic and Healthcare Inequalities.Healthcare (Basel, Switzerland) · 2026Article
- Multimorbidity Clusters Among People Aged 65 Years and Over in Australia: A Nationwide Cross-Sectional Data Linkage Study.The Medical journal of Australia · 2026Article
- A digital marker for stratifying cardiovascular metabolic comorbidities among the middle-aged and elderly adults.PLOS digital health · 2026Article
- Co-occurrence network characteristics and key comorbidity node identification based on health examination indicators among rural older adults aged 65 and above.BMC geriatrics · 2026Article
- An ageing biomarker signature predicts chronic disease cluster trajectories, physical function and mortality: validation in the TILDA and HRS cohorts.Age and ageing · 2026Article
- Observational
- Perioperative knowledge needs in maxillofacial trauma patients: a cross-sectional survey.BMC oral health · 2026Article
- A disease potential-driven graph attention model for comorbidity risk prediction of hypertension.Frontiers in big data · 2026Article
- Sex and age-specific multimorbidity profiles among working-age inpatients in China: a comparative network analysis.BMC public health · 2025Article
- Disease network analysis to reveal comorbidity patterns in hospitalized patients with COPD using large-scale administrative health data.Scientific reports · 2025Article
- Network-based machine learning reveals cardiometabolic multimorbidity patterns and modifiable lifestyle factors: a community-focused analysis of NHANES 2015-2018.BMC public health · 2025Article
- Central Role of Hypertension in HIV Comorbidity Networks: A Population-Based Study of Age and Sex-Specific Patterns in Southwest China.Journal of the American Heart Association · 2025Article
- Multimorbidity patterns of mental disorders and physical diseases of adults in northeast China: a cross-sectional network analysis.Epidemiology and psychiatric sciences · 2025Article
- Developing a framework for estimating comorbidity burden of inpatient cancer patients based on a case study in China.Global health research and policy · 2025Article
- Article
- Comorbidity Networks From Population-Wide Health Data: Aggregated Data of 8.9M Hospital Patients (1997-2014).Scientific data · 2025Article
- Sex- and age-specific multimorbidity networks in middle-aged inpatients: a network-based comparative study between China and the United Kingdom.Innovation in aging · 2025Article
- Identifying multimorbidity risks in older adults: a cross-sectional study using the RGA screening data.Frontiers in public health · 2025Article
- Population and Co-Occurrence Characteristics of Diagnoses and Comorbidities in Coronary Artery Disease Patients: A Case Study from a Hospital in Guangxi, China.Bioengineering (Basel, Switzerland) · 2024Article
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Authors and funding
18 authors at 9 institutions in 3 countries.
Funding
Abstract
backgroundMultimorbidity is better prevented in younger ages than in older ages. This study aims to identify the differences in comorbidity patterns in middle-aged inpatients from China and the United Kingdom (UK).
methodsWe utilized 184,133 and 180,497 baseline hospitalization records in middle-aged populations (40-59 years) from Shaanxi, China, and UK Biobank. Logistic regression was used to calculate odds ratios and P values for 43,110 unique comorbidity patterns in Chinese inpatients and 21,026 unique comorbidity patterns in UK inpatients. We included the statistically significant (P values adjusted by Bonferroni correction) and common comorbidity patterns (the pattern with prevalence > 1/10,000 in each dataset) and employed network analysis to construct multimorbidity networks and compare feature differences in multimorbidity networks for Chinese and UK inpatients, respectively. We defined hub diseases as diseases having the top 10 highest number of unique comorbidity patterns in the multimorbidity network.
resultsWe reported that 57.12% of Chinese inpatients had multimorbidity, substantially higher than 30.39% of UK inpatients. The complete multimorbidity network for Chinese inpatients consisted of 1367 comorbidities of 341 diseases and was 2.93 × more complex than that of 467 comorbidities of 215 diseases in the UK. In males, the complexity of the multimorbidity network in China was 2.69 × more than their UK counterparts, while the ratio was 2.63 × in females. Comorbidities associated with hub diseases represented 68.26% of comorbidity frequencies in the complete multimorbidity network in Chinese inpatients and 55.61% in UK inpatients. Essential hypertension, dyslipidemia, type 2 diabetes mellitus, and gastritis and duodenitis were the hub diseases in both populations. The Chinese inpatients consistently demonstrated a higher frequency of comorbidities related to circulatory and endocrine/nutritional/metabolic diseases. In the UK, aside from these comorbidities, comorbidities related to digestive and genitourinary diseases were also prevalent, particularly the latter among female inpatients.
conclusionsChinese inpatients exhibit higher multimorbidity prevalence and more complex networks compared to their UK counterparts. Multimorbidity with circulatory and endocrine/nutritional/metabolic diseases among both Chinese and UK inpatients necessitates tailored surveillance, prevention, and intervention approaches. Targeted interventions for digestive and genitourinary diseases are warranted for the UK.
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