Evidence map›Paper›PMID 38093134›Full record

ArticleDoklady. Biochemistry and biophysics2023

Ectopic BH3-Only Protein Bim Associates with Hsp70 to Regulate Yeast Mitophagy.

Linjie Yuan, Yuying Wang, B A Margulis, Ting Song, Ziqian Wang, Zhichao Zhang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Doklady. Biochemistry and biophysics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Linjie YuanSchool of Chemistry, Dalian University of Technology, Dalian, China.
Yuying WangSchool of Life Science and Technology, Dalian University of Technology, Dalian, China.
B A MargulisInstitute of Cytology, Russian Academy of Sciences, St. Petersburg, Russia.
Ting SongSchool of Chemistry, Dalian University of Technology, Dalian, China. songting@dlut.edu.cn.
Ziqian WangSchool of Chemistry, Dalian University of Technology, Dalian, China.
Zhichao ZhangSchool of Chemistry, Dalian University of Technology, Dalian, China. zczhang@dlut.edu.cn.
Dalian University of Technology · CNInstitute of Cytology · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mitophagy, a form of selective autophagy, plays an essential role to maintain a population of healthy and functional mitochondria for normal cellular metabolism. Acting mainly as one of the B-cell lymphoma 2 (Bcl-2) family pro-apoptotic members, Bim (also known as BCL2L11) was identified to be a co-chaperone of Hsp70 to promote mitophagy in mammalian cells. Herein, with the help of a specific Hsp70/Bim disruptor and Om45-GFP processing assay, we illustrated that ectopic BimEL is able to promote mitophagy through Hsp70/Bim interaction in yeast, where Bax/Bak is absent. The Hsp70/Bim-mediated mitophagy is conserved in eukaryotes, from yeast to humans.

Indexed as

Proto-Oncogene ProteinsSaccharomyces cerevisiaeAnimalsApoptosisApoptosis Regulatory ProteinsBcl-2-Like Protein 11HumansMammalsMembrane ProteinsMitophagyApoptosis Regulatory ProteinsBcl-2-Like Protein 11Membrane ProteinsProto-Oncogene ProteinsB-cell lymphoma 2 familyBimHsp70mitophagyyeast

Identifiers

PMID38093134
PMCPMC10719147
OpenAlexW4389664677

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.