Evidence map›Paper›PMID 38093125›Full record

ArticleDoklady. Biochemistry and biophysics2023

Simulated Microgravity Changes the Number of Mechanically Gated and Mechanosensitive Ion Channels Genes Transcripts in Rat Ventricular Cardiomyocytes.

A G Kamkin, V M Mitrokhin, O V Kamkina, V E Kazansky, A S Rodina, A D Zolotareva, V I Zolotarev, P V Sutyagin, M I Mladenov, B S Shenkman and 2 more

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In one paragraph

Article in Doklady. Biochemistry and biophysics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

A G KamkinPirogov Russian National Research Medical University, Moscow, Russia. andre.gleb.kamkin@gmail.com.
V M MitrokhinPirogov Russian National Research Medical University, Moscow, Russia.
O V KamkinaPirogov Russian National Research Medical University, Moscow, Russia.
V E KazanskyPirogov Russian National Research Medical University, Moscow, Russia.
A S RodinaPirogov Russian National Research Medical University, Moscow, Russia.
A D ZolotarevaPirogov Russian National Research Medical University, Moscow, Russia.
V I ZolotarevPirogov Russian National Research Medical University, Moscow, Russia.
P V SutyaginPirogov Russian National Research Medical University, Moscow, Russia.
M I MladenovPirogov Russian National Research Medical University, Moscow, Russia.
B S ShenkmanState Scientific Center of Russian Federation Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, Russia.
V E KalashnikovState Scientific Center of Russian Federation Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, Russia.
O I OrlovState Scientific Center of Russian Federation Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, Russia.
Pirogov Russian National Research Medical University · RUInstitute of Biomedical Problems · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The mechanoelectrical feedback in the heart is based on the work of mechanically gated (MGCs) and mechanosensitive (MSCs) channels. Since microgravity alters the heart's morphological and physiological properties, we hypothesized that the expression of both MGCs and MSCs would be affected. We employed RNA transcriptome sequencing to investigate changes in the gene transcript levels of MGCs and MSCs in isolated rat ventricular cardiomyocytes under control conditions and in a simulated microgravity environment. For the first time, our findings demonstrated that simulated microgravity induces alterations in the gene transcript levels of specific MGCs, such as TRPM7, TRPV2, TRPP1, TRPP2, Piezo1, TMEM63A, TMEM36B, and known MSCs, including K

Indexed as

Myocytes, CardiacWeightlessnessAnimalsIon ChannelsRatsIon Channelscardiomyocyteschannel genes transcriptsgenes expressionheartmechanically gated and mechano-sensitive ion channelsmicrogravityratsventricles

Identifiers

PMID38093125
OpenAlexW4389664796

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.