Evidence map›Paper›PMID 38093095›Full record

ReviewNature reviews. Genetics2024

The transition from genomics to phenomics in personalized population health.

James T Yurkovich, Simon J Evans, Noa Rappaport, Jeffrey L Boore, Jennifer C Lovejoy, Nathan D Price, Leroy E Hood

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Genetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Omics Technologies in Molecular Biology.International journal of molecular sciences · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Review
  15. Longitudinal big biological data in the AI era.Molecular systems biology · 2025
    Review
  16. Article
  17. Review
  18. Review
  19. Genome-scale models in human metabologenomics.Nature reviews. Genetics · 2025
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

James T YurkovichPhenome Health, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-9403-509X
Simon J EvansPhenome Health, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-8112-9487
Noa RappaportCenter for Phenomic Health, The Buck Institute for Research on Aging, Novato, CA, USA.
Jeffrey L BoorePhenome Health, Seattle, WA, USA.
Jennifer C LovejoyPhenome Health, Seattle, WA, USA.
Nathan D PriceInstitute for Systems Biology, Seattle, WA, USA.
Leroy E HoodPhenome Health, Seattle, WA, USA. lee.hood@phenomehealth.org.ORCID http://orcid.org/0000-0001-7158-3678

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Modern health care faces several serious challenges, including an ageing population and its inherent burden of chronic diseases, rising costs and marginal quality metrics. By assessing and optimizing the health trajectory of each individual using a data-driven personalized approach that reflects their genetics, behaviour and environment, we can start to address these challenges. This assessment includes longitudinal phenome measures, such as the blood proteome and metabolome, gut microbiome composition and function, and lifestyle and behaviour through wearables and questionnaires. Here, we review ongoing large-scale genomics and longitudinal phenomics efforts and the powerful insights they provide into wellness. We describe our vision for the transformation of the current health care from disease-oriented to data-driven, wellness-oriented and personalized population health.

Indexed as

GenomicsPhenomics

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.