Evidence map›Paper›PMID 38093015›Full record

ArticleNature2024

In vitro production of cat-restricted Toxoplasma pre-sexual stages.

Ana Vera Antunes, Martina Shahinas, Christopher Swale, Dayana C Farhat, Chandra Ramakrishnan, Christophe Bruley, Dominique Cannella, Marie G Robert, Charlotte Corrao, Yohann Couté and 4 more

Open access · hybridAbstract read
In one paragraph

Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
19.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 68 citations in OpenAlex.

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    Review
  19. Vaccines · 2025
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4 · The record

Corrections and comments

  • Update of
    2023
5 · Who and what money

Authors and funding

14 authors at 3 institutions in 3 countries.

Ana Vera Antunes *Institute for Advanced Biosciences (IAB), Team Host-Pathogen Interactions and Immunity to Infection, INSERM U1209, CNRS UMR5309, University Grenoble Alpes, Grenoble, France.
Martina Shahinas *Institute for Advanced Biosciences (IAB), Team Host-Pathogen Interactions and Immunity to Infection, INSERM U1209, CNRS UMR5309, University Grenoble Alpes, Grenoble, France.ORCID 0000-0003-1409-6499
Christopher Swale *Institute for Advanced Biosciences (IAB), Team Host-Pathogen Interactions and Immunity to Infection, INSERM U1209, CNRS UMR5309, University Grenoble Alpes, Grenoble, France.ORCID 0000-0002-9739-7774
Dayana C FarhatInstitute for Advanced Biosciences (IAB), Team Host-Pathogen Interactions and Immunity to Infection, INSERM U1209, CNRS UMR5309, University Grenoble Alpes, Grenoble, France.
Chandra RamakrishnanInstitute of Parasitology, University of Zurich, Zurich, Switzerland.
Christophe BruleyUniversity Grenoble Alpes, CEA, INSERM, UA13 BGE, CNRS, CEA, Grenoble, France.
Dominique CannellaInstitute for Advanced Biosciences (IAB), Team Host-Pathogen Interactions and Immunity to Infection, INSERM U1209, CNRS UMR5309, University Grenoble Alpes, Grenoble, France.
Marie G RobertInstitute for Advanced Biosciences (IAB), Team Host-Pathogen Interactions and Immunity to Infection, INSERM U1209, CNRS UMR5309, University Grenoble Alpes, Grenoble, France.
Charlotte CorraoInstitute for Advanced Biosciences (IAB), Team Host-Pathogen Interactions and Immunity to Infection, INSERM U1209, CNRS UMR5309, University Grenoble Alpes, Grenoble, France.
Yohann CoutéUniversity Grenoble Alpes, CEA, INSERM, UA13 BGE, CNRS, CEA, Grenoble, France.ORCID 0000-0003-3896-6196
Adrian B HehlInstitute of Parasitology, University of Zurich, Zurich, Switzerland.ORCID 0000-0002-2110-4445
Alexandre BougdourInstitute for Advanced Biosciences (IAB), Team Host-Pathogen Interactions and Immunity to Infection, INSERM U1209, CNRS UMR5309, University Grenoble Alpes, Grenoble, France.
Isabelle CoppensDepartment of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health and Malaria Research Institute, Baltimore, MD, USA.
Mohamed-Ali HakimiInstitute for Advanced Biosciences (IAB), Team Host-Pathogen Interactions and Immunity to Infection, INSERM U1209, CNRS UMR5309, University Grenoble Alpes, Grenoble, France. mohamed-ali.hakimi@inserm.fr.ORCID 0000-0002-2547-8233
Centre National de la Recherche Scientifique · FRUniversity of Zurich · CHJohns Hopkins University · US

Funding

Targeting of host vesicles to the vacuole of Toxoplasma and lipid cargo sortingR01AI060767 · NIAID · JOHNS HOPKINS UNIVERSITY · PI COPPENS, ISABELLE · 2004 to 2020
$5.1M
NIAID NIH HHS R01 AI060767
6 · The paper itself

Abstract

Sexual reproduction of Toxoplasma gondii, confined to the felid gut, remains largely uncharted owing to ethical concerns regarding the use of cats as model organisms. Chromatin modifiers dictate the developmental fate of the parasite during its multistage life cycle, but their targeting to stage-specific cistromes is poorly described

Indexed as

CatsIn Vitro TechniquesLife Cycle StagesToxoplasmaAnimalsChromatinDisease Models, AnimalEpigenesis, GeneticHistone Deacetylase 3HumansMerozoitesNuclear ProteinsPromoter Regions, GeneticProtozoan ProteinsToxoplasmosisTranscription, GeneticChromatinHistone Deacetylase 3Nuclear ProteinsProtozoan Proteins

Identifiers

PMID38093015
PMCPMC10781626
OpenAlexW4389671973

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.