Evidence map›Paper›PMID 38093008›Full record

ArticleNature2024

Large-scale single-neuron speech sound encoding across the depth of human cortex.

Matthew K Leonard, Laura Gwilliams, Kristin K Sellers, Jason E Chung, Duo Xu, Gavin Mischler, Nima Mesgarani, Marleen Welkenhuysen, Barundeb Dutta, Edward F Chang

Registry-linked trialOpen access · hybridAbstract read
In one paragraph

Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06617208 (Prognostic IntraOperative Biomarkers ideNtification in Tumor rElatEd suRgery), which is not on this map. Cited by 89 papers.

0numbers the graph read from it
0cells of the map it votes in
89citing papers in PubMed
24.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06617208 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Prognostic IntraOperative Biomarkers ideNtification in Tumor rElatEd suRgery (PIONEER Study)

TypeinterventionalSponsorErasmus Medical CenterRan2025 to 2029Enrolled10ConditionsGlioma, Glioblastoma (GBM), Brain Tumor-GliomaArmsNeuropixel probe recording
3 · Its place in the literature

Who cites it

89 citing papers in PubMed, 142 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. A single cortical circuit implements fast and slow visual search.bioRxiv : the preprint server for biology · 2026
    Article
  5. Temporally structured motor and auditory representations in covert syllable production.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article

29 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Matthew K Leonard *Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0002-8530-880X
Laura Gwilliams *Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Kristin K SellersDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0002-0517-2296
Jason E ChungDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Duo XuDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0002-8259-8688
Gavin MischlerMortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA.
Nima MesgaraniMortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA.ORCID 0000-0002-2987-759X
Marleen WelkenhuysenIMEC, Leuven, Belgium.ORCID 0000-0001-6729-9391
Barundeb DuttaIMEC, Leuven, Belgium.ORCID 0000-0003-4781-9630
Edward F ChangDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA. edward.chang@ucsf.edu.ORCID 0000-0003-2480-4700
University of California, San Francisco · USColumbia University · USIMEC · BE

Funding

Functional organization of the superior temporal gyrus for speech perceptionR01DC012379 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Edward Chang · 2012 to 2026
$8.3M
NINDS Research Education Programs for Residents and Fellows in Neurology, Neurosurgery, Neuropathology, Neuroradiology and Emergency Medicine (R25)R25NS070680 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOSEPHSON, SCOTT ANDREW · 2010 to 2023
$6.8M
Neurophysiology of robust speech perception in human superior temporal gyrusR01DC014279 · NIDCD · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Nima MESGARANI · 2015 to 2026
$5.3M
Characterizing the temporal processing of speech in the human auditory cortexR01DC018805 · NIDCD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI FLINKER, ADEEN, MESGARANI, NIMA · 2021 to 2025
$3.3M
NINDS Research Education Programs for Residents and Fellows in Neurology, Neurosurgery, Neuropathology, Neuroradiology and Emergency Medicine (R25)UE5NS070680 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Scott Andrew Josephson · 2024 to 2026
$2.6M
NIDCD NIH HHS R01 DC012379NIDCD NIH HHS R01 DC014279NIDCD NIH HHS R01 DC018805NINDS NIH HHS R25 NS070680NINDS NIH HHS UE5 NS070680
6 · The paper itself

Abstract

Understanding the neural basis of speech perception requires that we study the human brain both at the scale of the fundamental computational unit of neurons and in their organization across the depth of cortex. Here we used high-density Neuropixels arrays

Indexed as

Auditory CortexNeuronsSpeech PerceptionTemporal LobeAcoustic StimulationCuesElectrodesHumansPhoneticsSpeech

Identifiers

PMID38093008
PMCPMC10866713
OpenAlexW4389670578

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.