Evidence map›Paper›PMID 38092918›Full record

ArticleNature2023

Conserved and divergent gene regulatory programs of the mammalian neocortex.

Nathan R Zemke, Ethan J Armand, Wenliang Wang, Seoyeon Lee, Jingtian Zhou, Yang Eric Li, Hanqing Liu, Wei Tian, Joseph R Nery, Rosa G Castanon and 23 more

Erratum issuedOpen access · hybridAbstract readComparative Study
In one paragraph

Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 73 papers.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed
15.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 100 citations in OpenAlex.

  1. Review
  2. Article
  3. Ancient vocabulary for evolving cells.Nature ecology & evolution · 2026
    Article
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  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Genomic-microbial coevolution in human development: chromosome 2 fusion, and human accelerated regions.Mammalian genome : official journal of the International Mammalian Genome Society · 2026
    Review
  19. ModelingbioRxiv : the preprint server for biology · 2026
    Article
  20. A Community Standard Multispecies Cell Atlas of the Basal Ganglia.bioRxiv : the preprint server for biology · 2026
    Article

13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

33 authors at 7 institutions in 1 country.

Nathan R Zemke *Department of Cellular and Molecular Medicine, University of California, San Diego School of Medicine, La Jolla, CA, USA.
Ethan J Armand *Department of Cellular and Molecular Medicine, University of California, San Diego School of Medicine, La Jolla, CA, USA.
Wenliang WangGenomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Seoyeon LeeDepartment of Cellular and Molecular Medicine, University of California, San Diego School of Medicine, La Jolla, CA, USA.
Jingtian ZhouBioinformatics and Systems Biology Program, University of California, San Diego, La Jolla, CA, USA.
Yang Eric LiDepartment of Cellular and Molecular Medicine, University of California, San Diego School of Medicine, La Jolla, CA, USA.ORCID 0000-0001-6997-6018
Hanqing LiuGenomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Wei TianGenomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.
Joseph R NeryGenomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.ORCID 0000-0003-0153-5659
Rosa G CastanonGenomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.ORCID 0000-0003-1791-002X
Anna BartlettGenomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.ORCID 0000-0001-7059-4033
Julia K OsteenComputational Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.ORCID 0000-0001-7058-3297
Daofeng LiDepartment of Genetics, The Edison Family Center for Genome Sciences & Systems Biology, Washington University School of Medicine, St Louis, MO, USA.ORCID 0000-0001-7492-3703
Xiaoyu ZhuoDepartment of Genetics, The Edison Family Center for Genome Sciences & Systems Biology, Washington University School of Medicine, St Louis, MO, USA.ORCID 0000-0002-1400-5609
Vincent XuDepartment of Genetics, The Edison Family Center for Genome Sciences & Systems Biology, Washington University School of Medicine, St Louis, MO, USA.
Lei ChangDepartment of Cellular and Molecular Medicine, University of California, San Diego School of Medicine, La Jolla, CA, USA.
Keyi DongDepartment of Cellular and Molecular Medicine, University of California, San Diego School of Medicine, La Jolla, CA, USA.
Hannah S IndralingamDepartment of Cellular and Molecular Medicine, University of California, San Diego School of Medicine, La Jolla, CA, USA.
Jonathan A RinkComputational Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.ORCID 0009-0007-4651-0443
Yang XieDepartment of Cellular and Molecular Medicine, University of California, San Diego School of Medicine, La Jolla, CA, USA.ORCID 0000-0002-7453-6786
Michael MillerDepartment of Cellular and Molecular Medicine, University of California, San Diego School of Medicine, La Jolla, CA, USA.ORCID 0000-0003-0781-7868
Fenna M KrienenPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.ORCID 0000-0002-1400-6820
Qiangge ZhangStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Naz TaskinAllen Institute for Brain Science, Seattle, WA, USA.
Jonathan TingAllen Institute for Brain Science, Seattle, WA, USA.
Guoping FengStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0002-8021-277X
Steven A McCarrollDepartment of Genetics, Harvard Medical School, Boston, USA.ORCID 0000-0002-6954-8184
Edward M CallawaySystems Neurobiology Laboratories, The Salk Institute for Biological Studies, La Jolla, CA, USA.ORCID 0000-0002-6366-5267
Ting WangDepartment of Genetics, The Edison Family Center for Genome Sciences & Systems Biology, Washington University School of Medicine, St Louis, MO, USA.ORCID 0000-0002-6800-242X
Ed S LeinAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0001-9012-6552
M Margarita BehrensComputational Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.ORCID 0000-0002-7168-8186
Joseph R EckerGenomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA. ecker@salk.edu.ORCID 0000-0001-5799-5895
Bing RenDepartment of Cellular and Molecular Medicine, University of California, San Diego School of Medicine, La Jolla, CA, USA. biren@ucsd.edu.ORCID 0000-0002-5435-1127
Salk Institute for Biological Studies · USUniversity of California San Diego · USAllen Institute for Brain Science · USBroad Institute · USWashington University in St. Louis · USHarvard University · USJames S. McDonnell Foundation · US

Funding

Molecular SignaturesU19MH114831 · NIMH · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI DONG, HONG-WEI · 2017 to 2021
$24.6M
Center for Integrated Multi-modal and Multi-scale Nucleome ResearchUM1HG011585 · NHGRI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DULAC, CATHERINE, LEIN, ED · 2020 to 2024
$6.7M
Epigenomic cell-type classification and regulatory element identification in the human brainU01MH121282 · NIMH · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI BEHRENS, M MARGARITA, ECKER, JOSEPH R · 2019 to 2021
$5.4M
Illumina NovaSeq 6000 Sequencing SystemS10OD026929 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JEPSEN, KRISTEN LYNN · 2019 to 2019
$600k
REGULATION OF CORTICAL PHENOTYPE BY BASAL FOREBRAINF30MH011483 · NIMH · UNIVERSITY OF CALIFORNIA IRVINE · PI HA, DUN H · 1997 to 1999
–
NHGRI NIH HHS UM1 HG011585NIH HHS S10 OD026929NIMH NIH HHS F30 MH011483NIMH NIH HHS U01 MH121282NIMH NIH HHS U19 MH114831
6 · The paper itself

Abstract

Divergence of cis-regulatory elements drives species-specific traits

Indexed as

Conserved SequenceEvolution, MolecularGene Expression RegulationGene Regulatory NetworksMammalsNeocortexAnimalsCallithrixChromatinDNA MethylationDNA Transposable ElementsEpigenomeGenetic VariationHumansMacacaMiceChromatinDNA Transposable ElementsTranscription Factors

Identifiers

PMID38092918
PMCPMC10719095
OpenAlexW4389670259

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.