Evidence map›Paper›PMID 38092916›Full record

ArticleNature2023

A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain.

Zizhen Yao, Cindy T J van Velthoven, Michael Kunst, Meng Zhang, Delissa McMillen, Changkyu Lee, Won Jung, Jeff Goldy, Aliya Abdelhak, Matthew Aitken and 91 more

Open access · hybridAbstract read
In one paragraph

Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 787 papers.

0numbers the graph read from it
0cells of the map it votes in
787citing papers in PubMed
142.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

787 citing papers in PubMed, 927 citations in OpenAlex.

  1. Article
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  5. Review
  6. Calcium-Binding Protein Expression Cannot Serve as a General Classifier for GABAergic Neurons in the Macaque Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
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  17. Diffusion MRI reveals amyloid plaque-associated cellular signatures through spatial transcriptomic integration.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  18. Article
  19. Review
  20. Review

727 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

101 authors at 3 institutions in 1 country.

Zizhen YaoAllen Institute for Brain Science, Seattle, WA, USA. zizheny@alleninstitute.org.ORCID 0000-0002-9361-5607
Cindy T J van VelthovenAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0001-5120-4546
Michael KunstAllen Institute for Brain Science, Seattle, WA, USA.
Meng ZhangHoward Hughes Medical Institute, Department of Chemistry and Chemical Biology, Department of Physics, Harvard University, Cambridge, MA, USA.ORCID 0000-0002-9753-0635
Delissa McMillenAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-3413-4424
Changkyu LeeAllen Institute for Brain Science, Seattle, WA, USA.
Won JungHoward Hughes Medical Institute, Department of Chemistry and Chemical Biology, Department of Physics, Harvard University, Cambridge, MA, USA.ORCID 0000-0003-2810-5528
Jeff GoldyAllen Institute for Brain Science, Seattle, WA, USA.
Aliya AbdelhakAllen Institute for Brain Science, Seattle, WA, USA.
Matthew AitkenAllen Institute for Brain Science, Seattle, WA, USA.
Katherine BakerAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-5454-8026
Pamela BakerAllen Institute for Brain Science, Seattle, WA, USA.
Eliza BarkanAllen Institute for Brain Science, Seattle, WA, USA.
Darren BertagnolliAllen Institute for Brain Science, Seattle, WA, USA.
Ashwin BhandiwadAllen Institute for Brain Science, Seattle, WA, USA.
Cameron BielsteinAllen Institute for Brain Science, Seattle, WA, USA.
Prajal BishwakarmaAllen Institute for Brain Science, Seattle, WA, USA.
Jazmin CamposAllen Institute for Brain Science, Seattle, WA, USA.
Daniel CareyAllen Institute for Brain Science, Seattle, WA, USA.
Tamara CasperAllen Institute for Brain Science, Seattle, WA, USA.
Anish Bhaswanth ChakkaAllen Institute for Brain Science, Seattle, WA, USA.
Rushil ChakrabartyAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0003-1722-8557
Sakshi ChavanAllen Institute for Brain Science, Seattle, WA, USA.
Min ChenUniversity of Pennsylvania, Philadelphia, PA, USA.
Michael ClarkAllen Institute for Brain Science, Seattle, WA, USA.
Jennie CloseAllen Institute for Brain Science, Seattle, WA, USA.
Kirsten CrichtonAllen Institute for Brain Science, Seattle, WA, USA.
Scott DanielAllen Institute for Brain Science, Seattle, WA, USA.
Peter DiValentinAllen Institute for Brain Science, Seattle, WA, USA.
Tim DolbeareAllen Institute for Brain Science, Seattle, WA, USA.
Lauren EllingwoodAllen Institute for Brain Science, Seattle, WA, USA.
Elysha FiabaneAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0009-0003-9146-8812
Timothy FlissAllen Institute for Brain Science, Seattle, WA, USA.
James GeeUniversity of Pennsylvania, Philadelphia, PA, USA.
James GerstenbergerAllen Institute for Brain Science, Seattle, WA, USA.
Alexandra GlandonAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-1539-3332
Jessica GloeAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0001-8343-3423
Joshua GouldGenentech, San Francisco, CA, USA.
James GrayAllen Institute for Brain Science, Seattle, WA, USA.
Nathan GuilfordAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-6188-7333
Junitta GuzmanAllen Institute for Brain Science, Seattle, WA, USA.
Daniel HirschsteinAllen Institute for Brain Science, Seattle, WA, USA.
Windy HoAllen Institute for Brain Science, Seattle, WA, USA.
Marcus HooperAllen Institute for Brain Science, Seattle, WA, USA.
Mike HuangAllen Institute for Brain Science, Seattle, WA, USA.
Madie HuppAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-7444-5286
Kelly JinAllen Institute for Brain Science, Seattle, WA, USA.
Matthew KrollAllen Institute for Brain Science, Seattle, WA, USA.
Kanan LathiaAllen Institute for Brain Science, Seattle, WA, USA.
Arielle LeonAllen Institute for Brain Science, Seattle, WA, USA.
Su LiAllen Institute for Brain Science, Seattle, WA, USA.
Brian LongAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-7793-5969
Zach MadiganAllen Institute for Brain Science, Seattle, WA, USA.
Jessica MalloyAllen Institute for Brain Science, Seattle, WA, USA.
Jocelin MaloneAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0003-0794-4250
Zoe MaltzerAllen Institute for Brain Science, Seattle, WA, USA.
Naomi MartinAllen Institute for Brain Science, Seattle, WA, USA.
Rachel McCueAllen Institute for Brain Science, Seattle, WA, USA.
Ryan McGintyAllen Institute for Brain Science, Seattle, WA, USA.
Nicholas MeiAllen Institute for Brain Science, Seattle, WA, USA.
Jose MelchorAllen Institute for Brain Science, Seattle, WA, USA.
Emma MeyerdierksAllen Institute for Brain Science, Seattle, WA, USA.
Tyler MollenkopfAllen Institute for Brain Science, Seattle, WA, USA.
Skyler MoonsmanAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0009-0007-0734-9554
Thuc Nghi NguyenAllen Institute for Brain Science, Seattle, WA, USA.
Sven OttoAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0009-0002-8383-4272
Trangthanh PhamAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-4738-5062
Christine RimorinAllen Institute for Brain Science, Seattle, WA, USA.
Augustin RuizAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-8361-5152
Raymond SanchezAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0001-9141-090X
Lane SawyerAllen Institute for Brain Science, Seattle, WA, USA.
Nadiya ShapovalovaAllen Institute for Brain Science, Seattle, WA, USA.
Noah ShepardAllen Institute for Brain Science, Seattle, WA, USA.
Cliff SlaughterbeckAllen Institute for Brain Science, Seattle, WA, USA.
Josef SulcAllen Institute for Brain Science, Seattle, WA, USA.
Michael TieuAllen Institute for Brain Science, Seattle, WA, USA.
Amy TorkelsonAllen Institute for Brain Science, Seattle, WA, USA.
Herman TungAllen Institute for Brain Science, Seattle, WA, USA.
Nasmil Valera CuevasAllen Institute for Brain Science, Seattle, WA, USA.
Shane VanceAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0009-0007-7475-8526
Katherine WadhwaniAllen Institute for Brain Science, Seattle, WA, USA.
Katelyn WardAllen Institute for Brain Science, Seattle, WA, USA.
Boaz LeviAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-8346-872X
Colin FarrellAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0003-3487-3064
Rob YoungAllen Institute for Brain Science, Seattle, WA, USA.
Brian StaatsAllen Institute for Brain Science, Seattle, WA, USA.
Ming-Qiang Michael WangAllen Institute for Brain Science, Seattle, WA, USA.
Carol L ThompsonAllen Institute for Brain Science, Seattle, WA, USA.
Shoaib MuftiAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-8173-3884
Chelsea M PaganAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-3932-9992
Lauren KruseAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-3428-2443
Nick DeeAllen Institute for Brain Science, Seattle, WA, USA.
Susan M SunkinAllen Institute for Brain Science, Seattle, WA, USA.
Luke EspositoAllen Institute for Brain Science, Seattle, WA, USA.
Michael J HawrylyczAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-5741-8024
Jack WatersAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-2312-4183
Lydia NgAllen Institute for Brain Science, Seattle, WA, USA.
Kimberly SmithAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-3142-1970
Bosiljka TasicAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-6861-4506
Xiaowei ZhuangHoward Hughes Medical Institute, Department of Chemistry and Chemical Biology, Department of Physics, Harvard University, Cambridge, MA, USA.ORCID 0000-0002-6034-7853
Hongkui ZengAllen Institute for Brain Science, Seattle, WA, USA. hongkuiz@alleninstitute.org.ORCID 0000-0002-0326-5878
Allen Institute for Brain Science · USHoward Hughes Medical Institute · USUniversity of Pennsylvania · US

Funding

Generation of novel cell type specific mouse genetic toolsU19MH114830 · NIMH · ALLEN INSTITUTE · PI NGAI, JOHN J. · 2017 to 2021
$64.7M
DANDI: Distributed Archives for Neurophysiology Data IntegrationR24MH117295 · NIMH · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Satrajit Sujit Ghosh, Yaroslav O Halchenko · 2019 to 2026
$11.6M
An extensible brain knowledge base and toolset spanning modalities for multi-species data-driven cell typesU24MH130918 · NIMH · ALLEN INSTITUTE · PI Satrajit Sujit Ghosh, Michael Hawrylycz · 2022 to 2026
$10.0M
Establishing a Comprehensive and Standardized Cell Type Characterization PlatformU01MH105982 · NIMH · ALLEN INSTITUTE · PI ANDERSON, DAVID J, ZENG, HONGKUI · 2014 to 2016
$5.1M
NIMH NIH HHS R24 MH117295NIMH NIH HHS U01 MH105982NIMH NIH HHS U19 MH114830NIMH NIH HHS U24 MH130918
6 · The paper itself

Abstract

The mammalian brain consists of millions to billions of cells that are organized into many cell types with specific spatial distribution patterns and structural and functional properties

Indexed as

BrainGene Expression ProfilingTranscriptomeAnimalsDatasets as TopicIn Situ Hybridization, FluorescenceMiceNeural PathwaysNeuronsNeuropeptidesNeurotransmitter AgentsRNASingle-Cell Gene Expression AnalysisTranscription FactorsNeuropeptidesNeurotransmitter AgentsRNATranscription Factors

Identifiers

PMID38092916
PMCPMC10719114
OpenAlexW4389670555

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.