Evidence map›Paper›PMID 38092915›Full record

ArticleNature2023

The molecular cytoarchitecture of the adult mouse brain.

Jonah Langlieb, Nina S Sachdev, Karol S Balderrama, Naeem M Nadaf, Mukund Raj, Evan Murray, James T Webber, Charles Vanderburg, Vahid Gazestani, Daniel Tward and 8 more

Abstract read
In one paragraph

Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 123 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
123citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

123 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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63 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Jonah Langlieb *Broad Institute of Harvard and MIT, Cambridge, MA, USA.ORCID 0000-0002-9949-1123
Nina S Sachdev *Broad Institute of Harvard and MIT, Cambridge, MA, USA.ORCID 0000-0001-6059-0581
Karol S BalderramaBroad Institute of Harvard and MIT, Cambridge, MA, USA.ORCID 0000-0001-8458-1364
Naeem M NadafBroad Institute of Harvard and MIT, Cambridge, MA, USA.ORCID 0000-0002-7805-8523
Mukund RajBroad Institute of Harvard and MIT, Cambridge, MA, USA.ORCID 0000-0003-0593-3945
Evan MurrayBroad Institute of Harvard and MIT, Cambridge, MA, USA.
James T WebberBroad Institute of Harvard and MIT, Cambridge, MA, USA.ORCID 0000-0001-8594-9888
Charles VanderburgBroad Institute of Harvard and MIT, Cambridge, MA, USA.ORCID 0000-0001-8979-5054
Vahid GazestaniBroad Institute of Harvard and MIT, Cambridge, MA, USA.
Daniel TwardDepartments of Computational Medicine and Neurology, University of California, Los Angeles, Los Angeles, CA, USA.
Chris MeziasCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
Xu LiCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
Katelyn FlowersBroad Institute of Harvard and MIT, Cambridge, MA, USA.
Dylan M CableBroad Institute of Harvard and MIT, Cambridge, MA, USA.
Tabitha NortonBroad Institute of Harvard and MIT, Cambridge, MA, USA.
Partha MitraCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.ORCID 0000-0001-8818-6804
Fei ChenBroad Institute of Harvard and MIT, Cambridge, MA, USA. chenf@broadinstitute.org.ORCID 0000-0003-2308-3649
Evan Z MacoskoBroad Institute of Harvard and MIT, Cambridge, MA, USA. emacosko@broadinstitute.org.ORCID 0000-0002-2794-5165

Funding

Tool and Technology Development CoreU19MH114821 · NIMH · COLD SPRING HARBOR LABORATORY · PI ARLOTTA, PAOLA, HUANG, Z JOSH · 2017 to 2021
$64.5M
A high-resolution molecular and lineage atlas of the mouse brain using Slide-seqRF1MH124598 · NIMH · BROAD INSTITUTE, INC. · PI CHEN, FEI, MACOSKO, EVAN Z · 2020 to 2020
$1.9M
NIMH NIH HHS RF1 MH124598NIMH NIH HHS U19 MH114821
6 · The paper itself

Abstract

The function of the mammalian brain relies upon the specification and spatial positioning of diversely specialized cell types. Yet, the molecular identities of the cell types and their positions within individual anatomical structures remain incompletely known. To construct a comprehensive atlas of cell types in each brain structure, we paired high-throughput single-nucleus RNA sequencing with Slide-seq

Indexed as

BrainGene Expression ProfilingAnimalsHigh-Throughput Nucleotide SequencingHypothalamusMesencephalonMiceNeuropeptidesNeurotransmitter AgentsPhenotypeRhombencephalonSingle-Cell Gene Expression AnalysisTranscriptomeNeuropeptidesNeurotransmitter Agents

Identifiers

PMID38092915
PMCPMC10719111

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.