ArticleNature2023
A transcriptomic taxonomy of mouse brain-wide spinal projecting neurons.
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Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30citing papers in PubMed
9.6field-weighted citation impact, top 1% of its field
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30 citing papers in PubMed, 48 citations in OpenAlex.
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- Cluster replicability in single-cell and single-nucleus atlases of the mouse brain.Nature communications · 2026Article
- Conserved Cell Type Signatures Across the Brainstem and Spinal Cord in the Mouse Central Nervous System.bioRxiv : the preprint server for biology · 2026Article
- A Community Standard Multispecies Cell Atlas of the Basal Ganglia.bioRxiv : the preprint server for biology · 2026Article
- A transcriptomic axis aligns with in vivo functional dynamics in hippocampal inhibitory circuits.bioRxiv : the preprint server for biology · 2026Article
- A spatial and projection-based transcriptomic atlas of paraventricular hypothalamic cell types.Cell reports · 2026Article
- Ngn2 and Isl1-mediated astrocyte-to-neuron conversion in vivo promotes functional recovery after spinal cord injury.Cell reports. Medicine · 2025Article
- Activation of hypothalamic-pontine-spinal pathway promotes locomotor initiation and functional recovery after spinal cord injury in mice.Nature communications · 2025Article
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- Comprehensive Single-Cell Transcriptomic Atlas of the Mouse Pons and Medulla.Scientific data · 2025Article
- Motor Cortical Output Integrates Distorted Proprioceptive Feedback.bioRxiv : the preprint server for biology · 2025Article
- A spatial and projection-based transcriptomic atlas of paraventricular hypothalamic cell types.Research square · 2025Article
- Evolutionary expansion of the corticospinal system is linked to dexterity inbioRxiv : the preprint server for biology · 2025Article
- Article
- From thought to action: The organization of spinal projecting neurons.Cell reports · 2025Review
- Descending projection neurons in the primary sensorimotor cortex regulate neuropathic pain and locomotion in mice.Nature communications · 2025Article
- Stimulation of corticospinal neurons by optogenetic cAMP inductions promotes motor recovery after spinal cord injury in female rats via raphespinal tract modulation.Nature communications · 2025Article
- Projection-TAGs enable multiplex projection tracing and multi-modal profiling of projection neurons.Nature communications · 2025Article
- Proteomics-based characterization of ribosome heterogeneity in adult mouse organs.Cellular and molecular life sciences : CMLS · 2025Article
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Authors and funding
36 authors at 7 institutions in 2 countries.
Carla C Winter *F. M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.ORCID 0000-0003-3013-0394
Anne Jacobi *F. M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA. Anne.Jacobi@roche.com.ORCID 0000-0002-8197-3554
Junfeng Su *F. M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.ORCID 0000-0002-3415-5655
Leeyup ChungF. M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.
Cindy T J van VelthovenAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0001-5120-4546
Zizhen YaoAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-9361-5607
Changkyu LeeAllen Institute for Brain Science, Seattle, WA, USA.
Zicong ZhangF. M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.
Shuguang YuF. M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.
Kun GaoSemel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Geraldine Duque SalazarF. M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.
Evgenii KegelesF. M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.ORCID 0000-0003-2638-0454
Yu ZhangF. M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.
Makenzie C TomihiroF. M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.
Yiming ZhangF. M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.
Zhiyun YangF. M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.
Junjie ZhuF. M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.ORCID 0000-0002-3827-1741
Jing TangF. M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.
Xuan SongF. M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.
Ryan J DonahueF. M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.ORCID 0000-0003-2519-0763
Qing WangSemel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Delissa McMillenAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-3413-4424
Michael KunstAllen Institute for Brain Science, Seattle, WA, USA.
Ning WangAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0003-3073-7911
Kimberly A SmithAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-3142-1970
Gabriel E RomeroDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-6086-5546
Michelle M FrankDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-6613-8251
Alexandra KrolMcGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
Riki KawaguchiSemel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Daniel H GeschwindSemel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.ORCID 0000-0003-2896-3450
Guoping FengMcGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID 0000-0002-8021-277X
Lisa V GoodrichDepartment of Neurobiology, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-3331-8600
Yuanyuan LiuSomatosensation and Pain Unit, National Institute of Dental and Craniofacial Research, National Center for Complementary and Integrative Health, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-9865-1378
Bosiljka TasicAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-6861-4506
Hongkui ZengAllen Institute for Brain Science, Seattle, WA, USA. HongkuiZ@alleninstitute.org.ORCID 0000-0002-0326-5878
Zhigang HeF. M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA. zhigang.he@childrens.harvard.edu.ORCID 0000-0001-6080-6880
Boston Children's Hospital · USAllen Institute for Brain Science · USUniversity of California, Los Angeles · USHarvard University · USMcGovern Institute for Brain Research · USNational Institutes of Health · USRoche (Switzerland) · CH
Funding
Generation of novel cell type specific mouse genetic toolsU19MH114830 · NIMH · ALLEN INSTITUTE · PI NGAI, JOHN J. · 2017 to 2021
$64.7MMedical Scientist Training ProgramT32GM007753 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WALENSKY, LOREN DAVID · 1985 to 2021
$50.0MSYNAPTIC MECHANISMS IN HIPPOCAMPAL EPILEPTOGENESISP30HD018655 · NICHD · CHILDREN'S HOSPITAL BOSTON · PI POMEROY, SCOTT LOREN · 1985 to 2015
$26.2MViral ModuleP30EY012196 · NEI · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI MARGARET S LIVINGSTONE · 1998 to 2026
$21.3MMedical Scientist Training ProgramT32GM144273 · NIGMS · HARVARD MEDICAL SCHOOL · PI David Shumway Jones, Jacqueline A. Lees · 2022 to 2026
$14.7MGenetic Analysis and Manipulation Core (GAEC)P50HD105351 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI Hisashi Umemori · 2021 to 2026
$9.4MMechanism and optimization of CBD-mediated analgesic effects (Diversity Supplement)R01AT010779 · NCCIH · BOSTON CHILDREN'S HOSPITAL · PI HE, ZHIGANG, WANG, KUAN HONG · 2019 to 2023
$4.3MCortical Signature and Modulation of PainR01NS109947 · NINDS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI HE, ZHIGANG, WANG, FAN · 2018 to 2022
$4.0MTissueCyte 1600FC Whole Mount Tissue ScannerS10OD026866 · OD · HARVARD MEDICAL SCHOOL · PI SABATINI, BERNARDO L · 2019 to 2019
$612kBehavioral, molecular, and functional dissection of corticospinal neurons in motor performance deficits of physiological and pathological agingF30AG074598 · NIA · HARVARD MEDICAL SCHOOL · PI WINTER, CARLA · 2022 to 2024
$146kNCCIH NIH HHS R01 AT010779NEI NIH HHS P30 EY012196NIA NIH HHS F30 AG074598NICHD NIH HHS P30 HD018655NICHD NIH HHS P50 HD105351NIGMS NIH HHS T32 GM007753NIGMS NIH HHS T32 GM144273NIH HHS S10 OD026866NIMH NIH HHS U19 MH114830NINDS NIH HHS R01 NS109947
Abstract
The brain controls nearly all bodily functions via spinal projecting neurons (SPNs) that carry command signals from the brain to the spinal cord. However, a comprehensive molecular characterization of brain-wide SPNs is still lacking. Here we transcriptionally profiled a total of 65,002 SPNs, identified 76 region-specific SPN types, and mapped these types into a companion atlas of the whole mouse brain
Indexed as
BrainGene Expression ProfilingNeural PathwaysNeuronsSpinal CordAnimalsCerebellumCerebral CortexElectrophysiologyHypothalamusMesencephalonMiceNeuropeptidesNeurotransmitter AgentsReticular FormationNeuropeptidesNeurotransmitter Agents
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.