Evidence map›Paper›PMID 38092912›Full record

ArticleNature2023

Molecularly defined and spatially resolved cell atlas of the whole mouse brain.

Meng Zhang, Xingjie Pan, Won Jung, Aaron R Halpern, Stephen W Eichhorn, Zhiyun Lei, Limor Cohen, Kimberly A Smith, Bosiljka Tasic, Zizhen Yao and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 325 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
325citing papers in PubMed, 1 pooled it
65.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

325 citing papers in PubMed, 1 synthesis or guideline pooled it, 426 citations in OpenAlex.

  1. Pooled it
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  14. Calcium-binding protein expression cannot serve as a general classifier for GABAergic neurons in macaque cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
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265 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Meng Zhang *Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA.
Xingjie Pan *Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA.ORCID 0000-0002-0060-4352
Won Jung *Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA.ORCID 0000-0003-2810-5528
Aaron R HalpernHoward Hughes Medical Institute, Harvard University, Cambridge, MA, USA.ORCID 0000-0002-8149-0691
Stephen W EichhornHoward Hughes Medical Institute, Harvard University, Cambridge, MA, USA.
Zhiyun LeiHoward Hughes Medical Institute, Harvard University, Cambridge, MA, USA.ORCID 0009-0007-6796-2182
Limor CohenHoward Hughes Medical Institute, Harvard University, Cambridge, MA, USA.
Kimberly A SmithAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-3142-1970
Bosiljka TasicAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-6861-4506
Zizhen YaoAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-9361-5607
Hongkui ZengAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-0326-5878
Xiaowei ZhuangHoward Hughes Medical Institute, Harvard University, Cambridge, MA, USA. zhuang@chemistry.harvard.edu.ORCID 0000-0002-6034-7853
Howard Hughes Medical Institute · USAllen Institute for Brain Science · US

Funding

Generation of novel cell type specific mouse genetic toolsU19MH114830 · NIMH · ALLEN INSTITUTE · PI NGAI, JOHN J. · 2017 to 2021
$64.7M
NIMH NIH HHS U19 MH114830
6 · The paper itself

Abstract

In mammalian brains, millions to billions of cells form complex interaction networks to enable a wide range of functions. The enormous diversity and intricate organization of cells have impeded our understanding of the molecular and cellular basis of brain function. Recent advances in spatially resolved single-cell transcriptomics have enabled systematic mapping of the spatial organization of molecularly defined cell types in complex tissues

Indexed as

BrainSingle-Cell Gene Expression AnalysisAnimalsCell CommunicationGene Expression ProfilingIn Situ Hybridization, FluorescenceLigandsMiceNeural PathwaysTranscriptomeLigands

Identifiers

PMID38092912
PMCPMC10719103
OpenAlexW4389670373

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.