SynthesisScientific reports2023
The impact of difficult embryo transfer on the success of IVF: a systematic review and meta-analysis.
Synthesis in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.
- How embryo retention affects assisted reproductive technology outcomes: a systematic review and meta-analysis.Archives of gynecology and obstetrics · 2025Pooled it
- Effect of embryo retention on in vitro fertilization outcomes: a retrospective analysis.Journal of assisted reproduction and genetics · 2026Article
- Dynamic associations between ambient air pollution and transitions of biochemical pregnancy, clinical pregnancy, and live birth among women treated with IVF/ICSI.Journal of assisted reproduction and genetics · 2026Article
- Clinician-related variability as an independent determinant of in vitro fertilization success: A retrospective cohort study of intracytoplasmic sperm injection cycles.International journal of reproductive biomedicine · 2026Article
- Studies on the Possibility of Introducing New Materials into Reproductive Biotechnology and a New Type of Catheter for Embryo Transfer.Animals : an open access journal from MDPI · 2026Article
- Recurrent implantation failure: a registry-corroborated, age-stratified definition and pragmatic five-tiered management algorithm.Frontiers in endocrinology · 2026Review
- "How did it go?"-investigation of physician's experience during embryo transfer and subsequent pregnancy outcomes.Journal of assisted reproduction and genetics · 2025Article
- A standardized training allows achieving similar clinical pregnancy rates per top-quality euploid blastocyst transfer across operators.Journal of assisted reproduction and genetics · 2025Article
- When the Embryo Meets the Endometrium: Identifying the Features Required for Successful Embryo Implantation.International journal of molecular sciences · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The procedure of embryo transfer (ET) must be as gentle as possible since any traumatism may cause uterine contractility that interferes with the implantation. However, this ideal conduct is not always possible, and additional measures may be necessary (difficult ET). Different studies have evaluated the impact of difficult ET on the clinical pregnancy rate (CPR), but results were not univocal. The present systematic review and meta-analysis was aimed to provide a precise estimate of the possible detrimental effects of difficult ET on CPR. The study protocol was registered online (PROSPERO number: CRD42023387197). An electronic database search was performed to identify articles published until September 2022. The primary outcome was CPR. Fifteen studies fulfilled the inclusion criteria. Difficult ET significantly reduced the CPR (OR 0.70; 95%CI: 0.64-0.76; p < 0.0001. All pre-planned subgroup analyses according to study design (retrospective vs prospective studies), historical period (studies published before and after 2010), type of catheter, frequency of difficult cases (> or < 19%) and pregnancy rate (> or < 38%) confirmed the significant association. Difficult ET is associated with a significant reduction of CPR. Further studies are warranted to understand how to prevent or manage this common clinical situation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.