ArticleNature communications2023
Deep learning-based phenotyping reclassifies combined hepatocellular-cholangiocarcinoma.
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Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 3 of them syntheses that pooled it.
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59citing papers in PubMed, 3 pooled it
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Who cites it
59 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Assessment of the Diagnostic Performance and Clinical Impact of AI in Hepatic Steatosis: Systematic Review and Meta-Analysis.Journal of medical Internet research · 2026Pooled it
- Transforming histologic assessment: artificial intelligence in cancer diagnosis and personalized treatment.British journal of cancer · 2025Pooled it
- Comprehensive overview of artificial intelligence in surgery: a systematic review and perspectives.Pflugers Archiv : European journal of physiology · 2025Pooled it
- Accurate pathologic classification of aggressive myocarditis improves insights into patient precise medicine.Fundamental research · 2026Article
- Comprehensive molecular profiling of combined hepatocellular carcinoma and cholangiocarcinoma reveals distinct Notch signaling subgroups with prognostic significance.Virchows Archiv : an international journal of pathology · 2026Article
- Spatial transcriptomics in cancer research: insights into tumorigenesis, diagnosis and therapeutics.Cell death discovery · 2026Review
- [Artificial intelligence-assisted diagnostics in the pathology of internal and oncological diseases].Innere Medizin (Heidelberg, Germany) · 2026Review
- Deep learning based histomorphological phenotyping and prognostic stratification for combined SCLC and LCNEC.NPJ digital medicine · 2026Article
- Advances in In Vitro Diagnostics for Cholangiocarcinoma: From Biomarker Discovery to Artificial Intelligence.International journal of molecular sciences · 2026Review
- Heterogeneous Intermediate Phenotypes of Cancer Cells with Varying Ki-67-Positivity Rates, Including Histologically HCC-like and NEC-like Cells, in Liver MiNEN.International journal of molecular sciences · 2026Article
- Intratumoral heterogeneity of CT enhancement for component prediction and prognostic significance in combined hepatocellular carcinoma‑cholangiocarcinoma.European radiology · 2026Article
- Single-cell transcriptomic mapping of patient-derived primary liver cancer organoids reveals molecular subtypes and guides precision drug targeting.Cellular oncology (Dordrecht, Netherlands) · 2026Article
- Systemic therapy for combined hepatocellular-cholangiocarcinoma: a comprehensive review of chemotherapy, immunotherapy, and targeted therapy.Journal of liver cancer · 2026Review
- Prognostic model for pancreatic cancer based on machine learning of routine slides and transcriptomic tumor analysis.British journal of cancer · 2026Article
- Combined hepatocellular-cholangiocarcinoma: a contemporary pathologic and molecular perspective.Journal of liver cancer · 2026Review
- Systemic treatment strategies for combined hepatocellular-cholangiocarcinoma: current evidence and future direction.Journal of liver cancer · 2026Review
- Integrative Genomic and AI Approaches to Lung Cancer and Implications for Disease Prevention in Former Smokers.International journal of molecular sciences · 2026Review
- Beyond the convergence of metabolic reprogramming in primary liver cancer: a comprehensive review on energy and lipids metabolism.Frontiers in cell and developmental biology · 2026Review
- Spatial omics for profiling the dynamic tumor microenvironment.Clinical & translational immunology · 2026Review
- Preoperative 3D morphological phenotyping of hepatocellular carcinoma via a foundation model: a non-invasive biomarker for recurrence risk stratification.eGastroenterology · 2026Article
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Authors and funding
85 authors.
Julien CalderaroUniversité Paris Est Créteil, INSERM, IMRB, F-94010, Créteil, France. julien.calderaro@aphp.fr.
Narmin Ghaffari LalehElse Kroener Fresenius Center for Digital Health, Medical Faculty Carl Gustav Carus, Technical University Dresden, Dresden, Germany.
Qinghe ZengCentre d'Histologie, d'Imagerie et de Cytométrie (CHIC), Centre de Recherche des Cordeliers, Paris, France.ORCID 0000-0002-1473-8327
Pascale MailleUniversité Paris Est Créteil, INSERM, IMRB, F-94010, Créteil, France.
Loetitia FavreUniversité Paris Est Créteil, INSERM, IMRB, F-94010, Créteil, France.
Anaïs PujalsUniversité Paris Est Créteil, INSERM, IMRB, F-94010, Créteil, France.
Christophe KleinCentre d'Histologie, d'Imagerie et de Cytométrie (CHIC), Centre de Recherche des Cordeliers, Paris, France.ORCID 0000-0001-8015-287X
Céline BazilleCaen University Hospital, Department of Pathology, Caen, France.
Lara R HeijDepartment of Surgery and Transplantation, University Hospital RWTH Aachen, Aachen, Germany.ORCID 0000-0002-0602-3356
Arnaud UguenCHRU Brest, Department of Pathology, Brest, 29220, France.
Tom LueddeClinic for Gastroenterology, Hepatology and Infectious Diseases, University Hospital Düsseldorf, Medical Faculty of Heinrich Heine University Düsseldorf, Düsseldorf, Germany.ORCID 0000-0002-6288-8821
Luca Di TommasoDepartment of Pathology, Humanitas University, Humanitas Clinical and Research Center, IRCCS, Rozzano, Milan, Italy.ORCID 0000-0002-9013-4728
Aurélie BeaufrèreAssistance Publique-Hôpitaux de Paris, Beaujon University Hospital, Department of Pathology, F-92110, Clichy, France.
Augustin ChatainInserm, U955, Team 18, Créteil, France.
Delphine GastineauInserm, U955, Team 18, Créteil, France.
Cong Trung NguyenDepartment of Pathology, E Hospital, Hanoi Medical University, Hanoi, Vietnam.
Hiep Nguyen-CanhPathology Center, Bachmai Hospital, Hanoi, Vietnam.
Khuyen Nguyen ThiPathology and Molecular biology Center, National Cancer Hospital, Hanoi, Vietnam.
Viviane GnemmiUniversity Lille, UMR9020-U1277, Cancer Heterogeneity Plasticity and Resistance to Therapies, Lille, France.
Rondell P GrahamDepartment of Laboratory Medicine and Pathology, Mayo Clinic Rochester, Rochester, MN, USA.ORCID 0000-0002-8686-4867
Frédéric CharlotteAssistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière University Hospital, Department of Pathology, Paris, France.ORCID 0000-0003-2803-6606
Dominique WendumAssistance Publique-Hôpitaux de Paris, Saint-Antoine University Hospital, Department of Pathology, Paris, France.
Mukul VijDepartment of Pathology, Dr Rela Institute and Medical Centre, Bharath Institute of Higher Education and Research, Chennai, India.
Daniela S AllendeDepartment of Hepatobiliary Pathology, Cleveland Clinic Foundation, Cleveland, OH, USA.
Federico AucejoDepartment of Gastrointestinal and Hepatobiliary Surgery, Cleveland Clinic Foundation, Cleveland, OH, USA.
Alba DiazBarcelona Clinic Liver Cancer (BCLC) Group, Department of Pathology, Hospital Clínic de Barcelona, Universitat de Barcelona, Barcelona, Spain.ORCID 0000-0002-0456-7085
Benjamin RivièreDepartment of Pathology, Gui-de-Chauliac University Hospital, 80, avenue Augustin-Fliche, 34295, Montpellier, France.
Astrid HerreroDepartment of Digestive and Hepatobiliary Surgery, Gui-de-Chauliac University Hospital, 80, avenue Augustin-Fliche, 34295, Montpellier, France.ORCID 0000-0002-0036-909X
Katja EvertInstitute of Pathology, University of Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Germany.
Diego Francesco CalvisiInstitute of Pathology, University of Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Germany.
Jérémy AugustinUniversité Paris Est Créteil, INSERM, IMRB, F-94010, Créteil, France.
Wei Qiang LeowDepartment of Anatomical Pathology, Singapore General Hospital, Singapore, Singapore.
Howard Ho Wai LeungDepartment of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Shatin, Hong Kong.
Emmanuel BoleslawskiCHU Lille, Department of Digestive and Hepatobiliary Surgery, Lille, France.ORCID 0000-0003-3286-8608
Mohamed RelaDr Rela Institute and Medical Centre, Bharath Institute of Higher Education and Research, Chennai, India.
Arnaud FrançoisRouen University Hospital, Department of Pathology, Rouen, France.
Anthony Wing-Hung ChaDepartment of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Shatin, Hong Kong.
Alejandro FornerBarcelona Clinic Liver Cancer (BCLC), Liver Unit, Hospital Clinic of Barcelona, IDIBAPS, CIBEREHD, Universidad de Barcelona, Barcelona, Spain.ORCID 0000-0002-9014-4950
Maria ReigBarcelona Clinic Liver Cancer (BCLC), Liver Unit, Hospital Clinic of Barcelona, IDIBAPS, CIBEREHD, Universidad de Barcelona, Barcelona, Spain.ORCID 0000-0002-5711-9534
Manon AllaireAssistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière University Hospital, Department of Hepatology, Paris, France.
Olivier ScattonAssistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière University Hospital, Department of Digestive and Hepatobiliary Surgery, Paris, France.
Denis ChatelainCentre Hospitalier Universitaire d'Amiens, Département de Pathologie, Amiens, France.
Camille Boulagnon-RombiReims University Hospital, Department of Pathology, Reims, France.
Nathalie SturmDepartment of Pathology, University Hospital, Grenoble, France.
Benjamin MenahemCaen University Hospital, Department of Digestive and Hepatobiliary Surgery, Caen, France.
Eric FrouinPoitiers University Hospital, Department of Pathology, Poitiers, France.
David TougeronPoitiers University Hospital, Department of Hepatogastroenterology and Oncology, Poitiers, France.ORCID 0000-0002-8065-9635
Christophe TournigandAssistance Publique-Hôpitaux de Paris, Henri Mondor-Albert Chenevier University Hospital, Department of Medical Oncology, Créteil, France.
Emmanuelle KempfAssistance Publique-Hôpitaux de Paris, Henri Mondor-Albert Chenevier University Hospital, Department of Medical Oncology, Créteil, France.
Haeryoung KimDepartment of Pathology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
Massih NingarhariCHU Lille, Department of Hepatology, Lille, France.
Sophie Michalak-ProvostAngers University Hospital, Department of Pathology, Angers, France.
Purva GopalDepartment of Pathology, UT Southwestern Medical Center, Dallas, TX, USA.
Raffaele BrustiaAssistance Publique-Hôpitaux de Paris, Henri Mondor University Hospital, Department of Digestive and Hepatobiliary Surgery, Créteil, France.
Eric VibertAssistance Publique-Hôpitaux de Paris, Paul Brousse University Hospital, Department of Digestive and Hepatobiliary Surgery, Paris, France.
Kornelius SchulzeDepartment of Internal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Darius F RütherDepartment of Internal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Sören A WeidemannDepartment of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Rami RhaiemReims University Hospital, Department of Digestive and Hepatobiliary Surgery, Reims, France.
Jean-Michel PawlotskyUniversité Paris Est Créteil, INSERM, IMRB, F-94010, Créteil, France.ORCID 0000-0003-0745-7559
Xuchen ZhangDepartment of Pathology, Yale University School of Medicine, New Haven, CT, USA.
Alain LucianiAssistance Publique-Hôpitaux de Paris, Henri Mondor University Hospital, Department of Medical Imaging, Créteil, France.
Sébastien MuléAssistance Publique-Hôpitaux de Paris, Henri Mondor University Hospital, Department of Medical Imaging, Créteil, France.
Alexis LaurentAssistance Publique-Hôpitaux de Paris, Henri Mondor University Hospital, Department of Digestive and Hepatobiliary Surgery, Créteil, France.ORCID 0000-0003-1372-0843
Giuliana AmaddeoAssistance Publique-Hôpitaux de Paris, Henri Mondor University Hospital, Department of Hepatology, Créteil, France.
Hélène RegnaultAssistance Publique-Hôpitaux de Paris, Henri Mondor University Hospital, Department of Hepatology, Créteil, France.
Eleonora De MartinAssistance Publique-Hôpitaux de Paris, Paul Brousse University Hospital, Department of Hepatology, Paris, France.
Christine SempouxInstitute of Pathology, Lausanne University Hospital (CHUV), University of Lausanne (UNIL), Lausanne, Switzerland.
Pooja NavaleDepartment of Pathology and Immunology, Washington University in St. Louis, St. Louis, MO, 63110, USA.
Maria WesterhoffDepartment of Pathology University of Michigan, Ann Arbor, MI, USA.
Regina Cheuk-Lam LoDepartment of Pathology, The University of Hong Kong, Pok Fu Lam, Hong Kong, China.
Jan BednarschDepartment of Surgery and Transplantation, University Hospital RWTH Aachen, Aachen, Germany.
Annette GouwDepartment of Pathology and Medical Biology, University Medical Center Groningen, Groningen, the Netherlands.
Catherine GuettierDepartment of Surgery and Transplantation, University Hospital RWTH Aachen, Aachen, Germany.
Marie LequoyAssistance Publique-Hôpitaux de Paris, Saint Antoine University Hospital, Department of Hepatology, Paris, France.
Kenichi HaradaDepartment of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan.
Pimsiri SripongpunGastroenterology and Hepatology Unit, Division of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, Thailand.
Poowadon WetwittayaklangPrince of Songkla University, Department of Pathology, Hat Yai, Thailand.
Nicolas LoménieLaboratoire d'Informatique Paris Descartes (LIPADE), Université Paris Cité, Paris, France.ORCID 0000-0002-1467-3148
Jarukit TantipisitPrince of Songkla University, Department of Pathology, Hat Yai, Thailand.
Apichat KaewdechGastroenterology and Hepatology Unit, Division of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, Thailand.ORCID 0000-0002-4058-5977
Jeanne ShenCenter for Artificial Intelligence in Medicine and Imaging, Stanford University, 1701 Page Mill Road, Palo Alto, CA, 94304, USA.ORCID 0000-0002-1519-0308
Valérie ParadisAssistance Publique-Hôpitaux de Paris, Beaujon University Hospital, Department of Pathology, F-92110, Clichy, France.
Stefano CarusoUniversité Paris Est Créteil, INSERM, IMRB, F-94010, Créteil, France.
Jakob Nikolas KatherElse Kroener Fresenius Center for Digital Health, Medical Faculty Carl Gustav Carus, Technical University Dresden, Dresden, Germany. jakob_nikolas.kather@tu-dresden.de.ORCID 0000-0002-3730-5348
Funding
No grant is acknowledged in the PubMed record.
Abstract
Primary liver cancer arises either from hepatocytic or biliary lineage cells, giving rise to hepatocellular carcinoma (HCC) or intrahepatic cholangiocarcinoma (ICCA). Combined hepatocellular- cholangiocarcinomas (cHCC-CCA) exhibit equivocal or mixed features of both, causing diagnostic uncertainty and difficulty in determining proper management. Here, we perform a comprehensive deep learning-based phenotyping of multiple cohorts of patients. We show that deep learning can reproduce the diagnosis of HCC vs. CCA with a high performance. We analyze a series of 405 cHCC-CCA patients and demonstrate that the model can reclassify the tumors as HCC or ICCA, and that the predictions are consistent with clinical outcomes, genetic alterations and in situ spatial gene expression profiling. This type of approach could improve treatment decisions and ultimately clinical outcome for patients with rare and biphenotypic cancers such as cHCC-CCA.
Indexed as
Bile Duct NeoplasmsCarcinoma, HepatocellularCholangiocarcinomaDeep LearningLiver NeoplasmsBile Ducts, IntrahepaticHumansRetrospective Studies
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