Evidence map›Paper›PMID 38092705›Full record

ArticleSleep2024

Circadian blood pressure dysregulation in children with obstructive sleep apnea.

Md Tareq Ferdous Khan, David F Smith, Christine L Schuler, Abigail M Witter, Mark W DiFrancesco, Keren Armoni Domany, Raouf S Amin, Md Monir Hossain

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sleep, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Observational
  2. Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Md Tareq Ferdous KhanDivision of Biostatistics and Bioinformatics, Department of Environmental and Public Health Sciences, University of Cincinnati College of Medicine, Cincinnati, OH, USA.ORCID 0000-0002-2460-0604
David F SmithDivision of Pediatric Otolaryngology-Head and Neck Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.ORCID 0000-0002-0048-4012
Christine L SchulerDivision of Pulmonary Medicine and the Sleep Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Abigail M WitterDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Mark W DiFrancescoThe Imaging Research Center, Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.ORCID 0000-0001-8002-0332
Keren Armoni DomanyPediatric Pulmonology Unit, Wolfson Medical Center, Holon, Israel.
Raouf S AminDivision of Pulmonary Medicine and the Sleep Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Md Monir HossainDivision of Biostatistics and Bioinformatics, Department of Environmental and Public Health Sciences, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Cincinnati Children's Hospital Medical Center · USCleveland State University · USTel Aviv University · ILUniversity of Cincinnati Medical Center · US

Funding

Vascular Functions in Children with Sleep Disordered BreathingR01HL080670 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI AMIN, RAOUF S. · 2006 to 2010
$2.8M
Mechanisms Mediating C/V Disease in Children with OSAR01HL070907 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI AMIN, RAOUF S · 2003 to 2007
$1.8M
NHLBI NIH HHS R01 HL070907NHLBI NIH HHS R01 HL080670NIH HHS R01HL080670
6 · The paper itself

Abstract

STUDY

objectivesObstructive sleep apnea (OSA) adversely affects normal blood pressure (BP) and may disrupt circadian BP patterns. We sought to examine 24-hour circadian BP rhythms in children with OSA and healthy controls.

methodsChildren 5-14 years with OSA and healthy controls underwent 24-hour BP monitoring and actigraphy to quantify sleep. Shape invariant statistical models compared circadian BP patterns (e.g. times of BP peaks, time arrived at peak BP velocity [TAPV]) in the OSA and control groups.

resultsThe analytic sample included 219 children (mild OSA: n = 52; moderate-to-severe OSA (MS-OSA): n = 50; controls: n = 117). In the morning, the MS-OSA group had earlier TAPV for DBP than controls (51 minutes, p < 0.001). TAPV in the evening was earlier for the MS-OSA group than controls (SBP: 95 minutes, p < 0.001; DBP: 28 minutes, p = 0.028). At mid-day, SBP and DBP velocity nadirs were earlier for the MS-OSA group than controls (SBP: 57 minutes, p < 0.001; DBP: 38 minutes, p < 0.01). The MS-OSA group reached most BP values significantly earlier than controls; the largest differences were 118 minutes (SBP) and 43 minutes (DBP) (p < 0.001). SBP and DBP were elevated in the MS-OSA group (hours 18-21 and 7--12, respectively, p < 0.01) compared to controls. The MS-OSA group was prone to "non-dipping" compared to controls (SBP: odds ratio [OR] = 2.16, 95% CI: 1.09, 4.29; DBP: OR = 3.45, 95% CI: 1.21, 10.23).

conclusionsChildren with MS-OSA had changes in circadian BP patterns, namely earlier TAPV and BP peaks and nadirs than controls. Circadian disturbances in BP rhythms may be key to mapping the natural history of BP dysregulation in children with OSA.

Indexed as

HypertensionSleep Apnea, ObstructiveBlood PressureBlood Pressure Monitoring, AmbulatoryChildCircadian RhythmHumansSleepambulatory blood pressure monitoringchildCircadian rhythmshypertensionobstructive sleep apnea

Identifiers

PMID38092705
PMCPMC10851857
OpenAlexW4389703308

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.