Evidence map›Paper›PMID 38092682›Full record

ArticleClinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis

Prognostic Values Serum Cav-1 and NGB Levels in Early Neurological Deterioration After Intravenous Thrombolysis in Patients with Acute Ischemic Stroke.

Lihong Zhang, Cui Wang, Manhong Zhao, Xuesong Li, Hong Qu, Jianping Xu, Di Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Lihong ZhangDepartment of Neurointervention and Neurological Intensive Care, Dalian Central Hospital Affiliated to Dalian University of Technology, Dalian City, Liaoning Province, China.
Cui WangDepartment of Neurology, Dalian Central Hospital Affiliated to Dalian University of Technology, Dalian City, Liaoning Province, China.
Manhong ZhaoDepartment of Neurointervention and Neurological Intensive Care, Dalian Central Hospital Affiliated to Dalian University of Technology, Dalian City, Liaoning Province, China.
Xuesong LiDepartment of Radiology, Dalian Central Hospital Affiliated to Dalian University of Technology, Dalian City, Liaoning Province, China.
Hong QuBidding and Procurement Office, The Second Affiliated Hospital of Dalian Medical University, City, Liaoning Province, China.
Jianping XuDepartment of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou City, Jiangsu Province, China.
Di LiDepartment of Neurointervention and Neurological Intensive Care, Dalian Central Hospital Affiliated to Dalian University of Technology, Dalian City, Liaoning Province, China.ORCID 0009-0004-1540-6676
Dalian University of Technology · CNDalian Medical University · CNSoochow University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Early neurological deterioration after intravenous thrombolysis (IAT) leads to increased mortality and morbidity in patients with acute ischemic stroke (AIS). This study investigated the correlation between serum Cav-1 and NGB levels and END after IAT and explored their predictive values for poor prognosis of AIS. Totally 210 patients with AIS who underwent IAT within 4.5 h of onset were included and assigned into END group (n = 90) and Non-END group (n = 120). ELISA was used to detect serum Cav-1 and NGB levels before IAT in AIS patients. The prognosis of END patients after 3 months of treatment was evaluated using the modified Rankin Scale. Logistic multifactorial regression was used to analyze independent risk factors for END and poor prognosis after IAT. ROC curve was used to analyze the predictive effect of Cav-1 and NGB on END and poor prognosis after IAT. The area under the ROC curve was analyzed by MedCalc comparison. Compared with the Non-END group, serum Cav-1 was lower and NGB was higher in the END group. Cav-1 and NGB were independent risk factors for END after IAT. Cav-1 + NGB better predicted END after IAT than Cav-1 or NGB alone. Cav-1 and NGB were independent risk factors for END poor prognosis after IAT. Cav-1 combined with NGB better predicted poor prognosis of END after IAT than Cav-1 or NGB alone. Serum Cav-1 combined with NGB may assist in predicting the risk of END occurrence and poor prognosis after IAT in patients with AIS.

Indexed as

Brain IschemiaIschemic StrokeStrokeCaveolin 1Fibrinolytic AgentsHumansNeuroglobinPrognosisThrombolytic TherapyTreatment OutcomeCAV1 protein, humanCaveolin 1Fibrinolytic AgentsNeuroglobinNGB protein, humanacute ischemic strokecav-1intravenous thrombolysisneurological deteriorationNGBprognosisrt-PA

Identifiers

PMID38092682
PMCPMC10722930
OpenAlexW4389702722

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.