Evidence map›Paper›PMID 38092621›Full record

ArticleThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2024

Relationship of Hoarding and Depression Symptoms in Older Adults.

Sara Nutley, Binh K Nguyen, Robert Scott Mackin, Philip S Insel, Duygu Tosun, Meryl Butters, Paul Aisen, Rema Raman, Andrew J Saykin, Arthur W Toga and 8 more

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In one paragraph

Article in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 9 institutions in 1 country.

Sara NutleyDepartment of Psychiatry (SN, BN, CAM), University of Florida College of Medicine, Gainesville, FL; Center for OCD, Anxiety, and Related Disorders (COARD) (SN, BN, CAM), University of Florida, Gainesville, FL; Department of Epidemiology (SN), University of Florida, Gainesville, FL.
Binh K NguyenDepartment of Psychiatry (SN, BN, CAM), University of Florida College of Medicine, Gainesville, FL; Center for OCD, Anxiety, and Related Disorders (COARD) (SN, BN, CAM), University of Florida, Gainesville, FL.
Robert Scott MackinDepartment of Psychiatry and Behavioral Sciences (RM, PI, MW, CN, MK, MK-L, RN), University of California, San Francisco, San Francisco, CA; San Francisco Veterans Administration Medical Center (DT, MW, MK, JE), San Francisco, CA.
Philip S InselDepartment of Psychiatry and Behavioral Sciences (RM, PI, MW, CN, MK, MK-L, RN), University of California, San Francisco, San Francisco, CA.
Duygu TosunSan Francisco Veterans Administration Medical Center (DT, MW, MK, JE), San Francisco, CA; Department of Radiology (DT, MW, JE, RN), University of California, San Francisco, San Francisco, CA.
Meryl ButtersDepartment of Psychiatry (MB), University of Pittsburgh School of Medicine, Pittsburgh, PA.
Paul AisenUniversity of Southern California (PA, RR), San Diego, CA; Alzheimer's Therapeutic Research Institute (PA, RR), University of Southern California, San Diego, CA.
Rema RamanUniversity of Southern California (PA, RR), San Diego, CA; Alzheimer's Therapeutic Research Institute (PA, RR), University of Southern California, San Diego, CA.
Andrew J SaykinIndiana Alzheimer's Disease Research Center and Department of Radiology and Imaging Sciences (AS), Indiana University School of Medicine, Indianapolis, IN.
Arthur W TogaLaboratory of Neuro Imaging, Stevens Neuroimaging and Informatics Institute, Keck School of Medicine (AT), University of Southern California, Los Angeles, CA.
Clifford JackMayo Clinic (CJ), Rochester, MN.
Michael W WeinerDepartment of Psychiatry and Behavioral Sciences (RM, PI, MW, CN, MK, MK-L, RN), University of California, San Francisco, San Francisco, CA; San Francisco Veterans Administration Medical Center (DT, MW, MK, JE), San Francisco, CA; Department of Radiology (DT, MW, JE, RN), University of California, San Francisco, San Francisco, CA; Department of Neurology (MW), University of California, San Francisco, San Francisco, CA.
Craig NelsonDepartment of Psychiatry and Behavioral Sciences (RM, PI, MW, CN, MK, MK-L, RN), University of California, San Francisco, San Francisco, CA.
Michelle KasselDepartment of Psychiatry and Behavioral Sciences (RM, PI, MW, CN, MK, MK-L, RN), University of California, San Francisco, San Francisco, CA; San Francisco Veterans Administration Medical Center (DT, MW, MK, JE), San Francisco, CA.
Maria Kryza-LacombeDepartment of Psychiatry and Behavioral Sciences (RM, PI, MW, CN, MK, MK-L, RN), University of California, San Francisco, San Francisco, CA; Mental Illness Research Education and Clinical Centers (MK-L), Veterans Administration Medical Center, San Francisco, CA.
Joseph EichenbaumSan Francisco Veterans Administration Medical Center (DT, MW, MK, JE), San Francisco, CA; Department of Radiology (DT, MW, JE, RN), University of California, San Francisco, San Francisco, CA.
Rachel L NoshenyDepartment of Psychiatry and Behavioral Sciences (RM, PI, MW, CN, MK, MK-L, RN), University of California, San Francisco, San Francisco, CA; Department of Radiology (DT, MW, JE, RN), University of California, San Francisco, San Francisco, CA.
Carol A MathewsDepartment of Psychiatry (SN, BN, CAM), University of Florida College of Medicine, Gainesville, FL; Center for OCD, Anxiety, and Related Disorders (COARD) (SN, BN, CAM), University of Florida, Gainesville, FL. Electronic address: carolmathews@ufl.edu.
University of California, San Francisco · USFlorida College · USUniversity of Florida · USUniversity of Southern California · USIndiana University – Purdue University Indianapolis · USMayo Clinic in Arizona · USMental Illness Research, Education and Clinical Centers · USSouthern States University · USUniversity of Pittsburgh · US

Funding

USCADRC Diversity Supplement PachicanoP30AG066530 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HELENA Chang CHUI, ARTHUR W TOGA · 2020 to 2026
$27.8M
Characterizing Cognitive Decline in Late Life Depression: The ADNI-D ProjectR01MH098062 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Robert Scott Mackin · 2013 to 2026
$9.1M
Predicting populations at-risk of developing pathological hoardingR01MH117114 · NIMH · UNIVERSITY OF FLORIDA · PI MACKIN, ROBERT SCOTT, MATHEWS, CAROL A · 2018 to 2022
$3.7M
The Brain Health Registry for facilitating interdisciplinary aging researchR33AG062867 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NOSHENY, RACHEL LAUREN · 2020 to 2024
$3.2M
NIA NIH HHS P30 AG066530NIA NIH HHS R33 AG062867NIMH NIH HHS R01 MH098062NIMH NIH HHS R01 MH117114
6 · The paper itself

Abstract

Hoarding disorder (HD) is a debilitating neuropsychiatric condition that affects 2%-6% of the population and increases in incidence with age. Major depressive disorder (MDD) co-occurs with HD in approximately 50% of cases and leads to increased functional impairment and disability. However, only one study to date has examined the rate and trajectory of hoarding symptoms in older individuals with a lifetime history of MDD, including those with current active depression (late-life depression; LLD). We therefore sought to characterize this potentially distinct phenotype. We determined the incidence of HD in two separate cohorts of participants with LLD (n = 73) or lifetime history of MDD (n = 580) and examined the reliability and stability of hoarding symptoms using the Saving Inventory-Revised (SI-R) and Hoarding Rating Scale-Self Report (HRS), as well as the co-variance of hoarding and depression scores over time. HD was present in 12% to 33% of participants with MDD, with higher rates found in those with active depressive symptoms. Hoarding severity was stable across timepoints in both samples (all correlations >0.75), and fewer than 30% of participants in each sample experienced significant changes in severity between any two timepoints. Change in depression symptoms over time did not co-vary with change in hoarding symptoms. These findings indicate that hoarding is a more common comorbidity in LLD than previously suggested, and should be considered in screening and management of LLD. Future studies should further characterize the interaction of these conditions and their impact on outcomes, particularly functional impairment in this vulnerable population.

Indexed as

HoardingHoarding DisorderMajor Depressive DisorderAgedCompulsive BehaviorDepressionHumansReproducibility of ResultsBrain Health Registryhoarding disorderLate-life depressionmajor depressive disorderreliable changestability analysistrajectory analysis

Identifiers

PMID38092621
PMCPMC11055473
OpenAlexW4388934559

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.