Evidence map›Paper›PMID 38092521›Full record

ArticleGenes & development2023

The steroid hormone ADIOL promotes learning by reducing neural kynurenic acid levels.

George A Lemieux, Shinja Yoo, Lin Lin, Mihir Vohra, Kaveh Ashrafi

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes & development, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

George A LemieuxDepartment of Physiology, University of California, San Francisco, San Francisco, California 94143, USA.
Shinja YooDepartment of Physiology, University of California, San Francisco, San Francisco, California 94143, USA.
Lin LinDepartment of Physiology, University of California, San Francisco, San Francisco, California 94143, USA.
Mihir VohraDepartment of Physiology, University of California, San Francisco, San Francisco, California 94143, USA.
Kaveh AshrafiDepartment of Physiology, University of California, San Francisco, San Francisco, California 94143, USA kaveh.ashrafi@ucsf.edu.
University of California, San Francisco · US

Funding

UCSF Nutrition Obesity Research CenterP30DK098722 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHRISTIAN VAISSE · 2015 to 2026
$14.6M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Linking metabolism, neural function, and agingR01AG046400 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Kaveh Ashrafi · 2014 to 2026
$4.8M
Role of the steroid hormone ADIOL in learning and memory, aging, and neurodegenerationRF1AG068194 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ASHRAFI, KAVEH · 2021 to 2021
$1.7M
Xevo TQ-XS Triple Quadrupole Mass Spectrometer SystemS10OD026962 · OD · STANFORD UNIVERSITY · PI CHIEN, ALLIS SOE-LANG · 2019 to 2019
$527k
NIA NIH HHS R01 AG046400NIA NIH HHS RF1 AG068194NIDDK NIH HHS P30 DK098722NIH HHS P40 OD010440NIH HHS S10 OD026962
6 · The paper itself

Abstract

Reductions in brain kynurenic acid levels, a neuroinhibitory metabolite, improve cognitive function in diverse organisms. Thus, modulation of kynurenic acid levels is thought to have therapeutic potential in a range of brain disorders. Here we report that the steroid 5-androstene 3β, 17β-diol (ADIOL) reduces kynurenic acid levels and promotes associative learning in

Indexed as

Kynurenic AcidSteroidsAnimalsHormonesMammalsHormonesKynurenic AcidSteroids5-androstenediolestrogen receptor βkynurenic acidkynurenine pathwaynuclear hormone receptor

Identifiers

PMID38092521
PMCPMC10760639
OpenAlexW4389660952

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.