Evidence map›Paper›PMID 38092428›Full record

ArticleACS synthetic biology2024

Spatiotemporal Optical Control of Gαq-PLCβ Interactions.

Sithurandi Ubeysinghe, Dinesh Kankanamge, Waruna Thotamune, Dhanushan Wijayaratna, Thomas M Mohan, Ajith Karunarathne

Open access · greenAbstract read
In one paragraph

Article in ACS synthetic biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Optogenetic engineering for ion channel modulation.Current opinion in chemical biology · 2025
    Review
  4. Article
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Sithurandi UbeysingheDepartment of Chemistry, Saint Louis University, St. Louis, Missouri 63103, United States.
Dinesh KankanamgePain Center, Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
Waruna ThotamuneDepartment of Chemistry, Saint Louis University, St. Louis, Missouri 63103, United States.
Dhanushan WijayaratnaDepartment of Chemistry, Saint Louis University, St. Louis, Missouri 63103, United States.
Thomas M MohanDepartment of Chemistry, Saint Louis University, St. Louis, Missouri 63103, United States.
Ajith KarunarathneDepartment of Chemistry, Saint Louis University, St. Louis, Missouri 63103, United States.ORCID 0000-0003-3136-2015
Saint Louis University · USWashington University in St. Louis · US

Funding

Optical control of endogenous G protein Coupled Receptor and G Protein Signaling.R01GM140191 · NIGMS · UNIVERSITY OF TOLEDO · PI KARUNARATHNE, WELIVITIYA KANKANAMLAGE AJITH · 2021 to 2023
$1.0M
NIGMS NIH HHS R01 GM140191
6 · The paper itself

Abstract

Cells experience time-varying and spatially heterogeneous chemokine signals

Indexed as

Signal TransductionPhospholipase C betaPhospholipase C betacell migrationcellular signalingcryptochromeGPCRG proteinsHTHiLIDoptogeneticsPIP2PLCβRhoGEFsignal transduction

Identifiers

PMID38092428
PMCPMC11863898
OpenAlexW4389704356

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.