Evidence map›Paper›PMID 38092385›Full record

ArticleJournal of atherosclerosis and thrombosis2024

Impact of the Japanese Version of High Bleeding Risk Criteria on Clinical Outcomes in Patients with ST-segment Elevation Myocardial Infarction.

Satoshi Konoma, Kenichi Sakakura, Hiroyuki Jinnouchi, Yousuke Taniguchi, Takunori Tsukui, Masashi Hatori, Yusuke Tamanaha, Taku Kasahara, Yusuke Watanabe, Kei Yamamoto and 2 more

Abstract read
In one paragraph

Article in Journal of atherosclerosis and thrombosis, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Satoshi KonomaDivision of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University.
Kenichi SakakuraDivision of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University.
Hiroyuki JinnouchiDivision of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University.
Yousuke TaniguchiDivision of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University.
Takunori TsukuiDivision of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University.
Masashi HatoriDivision of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University.
Yusuke TamanahaDivision of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University.
Taku KasaharaDivision of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University.
Yusuke WatanabeDivision of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University.
Kei YamamotoDivision of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University.
Masaru SeguchiDivision of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University.
Hideo FujitaDivision of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsBleeding complications are often observed in patients with ST-segment elevation myocardial infarction (STEMI). Although the Japanese version of the high bleeding risk criteria (J-HBR) were established, it has not been sufficiently validated in patients with STEMI. This retrospective study aims to examine whether J-HBR is associated with cardiovascular and bleeding events in patients with STEMI.

methodsWe included 897 patients with STEMI and divided them into the J-HBR group (n=567) and the non-J-HBR group (n=330). The primary endpoint was the major adverse cardiovascular events (MACE), defined as the composite of all-cause death, non-fatal myocardial infarction, ischemic stroke, and systemic embolism. Another primary endpoint was total bleeding events defined as type 3 or 5 bleeding events as defined by the Bleeding Academic Research Consortium .

resultsDuring the median follow-up duration of 573 days, 187 MACE and 141 total bleeding events were observed. The Kaplan-Meier curves showed that MACE and total bleeding events were more frequently observed in the J-HBR group than in the non-J-HBR group (p<0.001). Multivariate Cox hazard analysis revealed that after controlling for multiple confounding factors, the J-HBR group was significantly associated with MACE (hazard ratio [HR] 4.676, 95% confidence interval (CI) 2.936-7.448, p<0.001) and total bleeding events (HR 6.325, 95% CI 3.376-11.851, p<0.001).

conclusionsJ-HBR is significantly associated with MACE and total bleeding events in patients with STEMI. This study validated J-HBR as a risk marker for bleeding events and suggests J-HBR as a potential risk marker for MACE in patients with STEMI.

Indexed as

HemorrhageST Elevation Myocardial InfarctionAgedFemaleFollow-Up StudiesHumansJapanMaleMiddle AgedPercutaneous Coronary InterventionPrognosisRetrospective StudiesRisk AssessmentRisk FactorsAcute myocardial infarctionHigh bleeding riskJ-HBRMajor cardiovascular eventsST-segment elevation myocardial infarction

Identifiers

PMID38092385
PMCPMC11150728

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.