Evidence map›Paper›PMID 38092343›Full record

ArticleEnvironmental pollution (Barking, Essex : 1987)2024

Prenatal exposures to organophosphate ester metabolites and early motor development in the MADRES cohort.

Ixel Hernandez-Castro, Sandrah P Eckel, Xinci Chen, Tingyu Yang, Mario J Vigil, Helen B Foley, Kurunthachalam Kannan, Morgan Robinson, Brendan Grubbs, Deborah Lerner and 8 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental pollution (Barking, Essex : 1987), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
4.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. SynergisticiScience · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 2 institutions in 1 country.

Ixel Hernandez-CastroDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Sandrah P EckelDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Xinci ChenDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Tingyu YangDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Mario J VigilDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Helen B FoleyDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Kurunthachalam KannanWadsworth Center, New York State Department of Health, Albany, NY, USA.
Morgan RobinsonWadsworth Center, New York State Department of Health, Albany, NY, USA.
Brendan GrubbsDepartment of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Deborah LernerEisner Health, Los Angeles, CA, USA.
Nathana LurveyEisner Health, Los Angeles, CA, USA.
Laila Al-MarayatiDepartment of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Rima HabreDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Genevieve F DuntonDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Department of Psychology, University of Southern California, Los Angeles, CA, USA.
Shohreh F FarzanDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Max T AungDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Carrie V BretonDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Theresa M BastainDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. Electronic address: bastain@usc.edu.
University of Southern California · USNew York State Department of Health · US

Funding

Translational Research Support CoreP30ES007048 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Joseph Leo Wiemels · 1996 to 2026
$46.4M
Lifecourse Approach to Developmental Repercussions of Environmental Agents on Metabolic and Respiratory Health (LA DREAMERs)UH3OD023287 · OD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BASTAIN, THERESA M, BRETON, CARRIE VAN DOREN · 2018 to 2022
$28.4M
Wadsworth Center's Human Health and Exposure Analysis Resource (WC-HHEAR)U2CES026542 · NIEHS · WADSWORTH CENTER · PI KANNAN, KURUNTHACHALAM, KANNAN, KURUNTHACHALAM · 2015 to 2025
$15.6M
Project 3: Maternal Exposure to Environmental Hazards and Psychosocial Stressors and Postpartum Allostatic LoadP50MD015705 · NIMHD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI FARZAN, SHOHREH F · 2020 to 2024
$8.1M
Project 2: Environmental Exposures, Stress, and Maternal Pregnancy-Related Weight OutcomesP50ES026086 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HABRE, RIMA · 2015 to 2019
$3.7M
NIEHS NIH HHS P30 ES007048NIEHS NIH HHS P50 ES026086NIEHS NIH HHS U2C ES026542NIH HHS UH3 OD023287NIMHD NIH HHS P50 MD015705
6 · The paper itself

Abstract

Organophosphate esters (OPEs) are increasingly considered neurotoxicants which may impact gross and fine motor development. We evaluated associations between prenatal OPE exposures and infant motor development. Third trimester urinary concentrations of nine OPE metabolites were measured in 329 mother-infant dyads participating in the Maternal And Developmental Risks from Environmental and Social Stressors (MADRES) cohort. Child gross and fine motor development at 6, 9, 12, and 18-months were assessed with the Ages and Stages Questionnaire-3 (ASQ-3) and operationalized in models using dichotomous instrument-specific cutoffs for typical motor development. Five OPE metabolites with >60% detection were specific-gravity-adjusted, natural log-transformed, and modeled continuously, while four metabolites with <60% detection were modeled dichotomously (detected/not-detected). We fit mixed effects logistic regression between OPE metabolites and fine/gross motor development and assessed sex-specific effects using a statistical interaction term and sex-stratified models. Among children, 31% and 23% had gross and fine motor scores, respectively, below the ASQ-3 at-risk cutoffs at least once across infancy. A doubling in prenatal diphenyl phosphate (DPHP) exposure was associated with 26% increased odds of potential fine motor delays (OR

Indexed as

Flame RetardantsPrenatal Exposure Delayed EffectsChildEstersFemaleHumansInfantMaleOrganophosphatesPhosphatesPregnancybis(1-chloro-2-propyl)phosphateEstersFlame RetardantsOrganophosphatesPhosphatesMotor developmentNeurodevelopmentOPEsPrenatal exposures

Identifiers

PMID38092343
PMCPMC10872268
OpenAlexW4389545983

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.