Evidence map›Paper›PMID 38092139›Full record

ArticleThe Journal of allergy and clinical immunology2024

Asthmatic patients with high serum amyloid A have proinflammatory HDL: Implications for augmented systemic and airway inflammation.

Xianglan Yao, Maryann Kaler, Xuan Qu, Rama Satyanarayana Raju Kalidhindi, Denis Sviridov, Amaury Dasseux, Eric Barr, Karen Keeran, Kenneth R Jeffries, Zu-Xi Yu and 13 more

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of allergy and clinical immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00001888 (Asthma Sample Collection Protocol), which is not on this map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00001888 completednot on this map

Asthma Sample Collection Protocol

TypeobservationalSponsorNational Heart, Lung, and Blood Institute (NHLBI)Ran1999Enrolled574ConditionsAsthma
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
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  3. Article
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  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 2 institutions in 1 country.

Xianglan YaoLaboratory of Asthma and Lung Inflammation, Pulmonary Branch, National Heart, Lung, and Blood Institute, Bethesda, Md.
Maryann KalerLaboratory of Asthma and Lung Inflammation, Pulmonary Branch, National Heart, Lung, and Blood Institute, Bethesda, Md.
Xuan QuLaboratory of Asthma and Lung Inflammation, Pulmonary Branch, National Heart, Lung, and Blood Institute, Bethesda, Md.
Rama Satyanarayana Raju KalidhindiLaboratory of Asthma and Lung Inflammation, Pulmonary Branch, National Heart, Lung, and Blood Institute, Bethesda, Md.
Denis SviridovLipoprotein Metabolism Laboratory, National Heart, Lung, and Blood Institute, Bethesda, Md.
Amaury DasseuxLipoprotein Metabolism Laboratory, National Heart, Lung, and Blood Institute, Bethesda, Md.
Eric BarrAnimal Surgery and Resources Core Facility, National Heart, Lung, and Blood Institute, Bethesda, Md.
Karen KeeranAnimal Surgery and Resources Core Facility, National Heart, Lung, and Blood Institute, Bethesda, Md.
Kenneth R JeffriesAnimal Surgery and Resources Core Facility, National Heart, Lung, and Blood Institute, Bethesda, Md.
Zu-Xi YuPathology Core Facility, National Heart, Lung, and Blood Institute, Bethesda, Md.
Meixia GaoLaboratory of Asthma and Lung Inflammation, Pulmonary Branch, National Heart, Lung, and Blood Institute, Bethesda, Md.
Scott GordonLipoprotein Metabolism Laboratory, National Heart, Lung, and Blood Institute, Bethesda, Md.
Amisha V BarochiaLaboratory of Asthma and Lung Inflammation, Pulmonary Branch, National Heart, Lung, and Blood Institute, Bethesda, Md.
Joni MillsLaboratory of Asthma and Lung Inflammation, Pulmonary Branch, National Heart, Lung, and Blood Institute, Bethesda, Md.
Shahid ShahidLaboratory of Asthma and Lung Inflammation, Pulmonary Branch, National Heart, Lung, and Blood Institute, Bethesda, Md.
Nargues A WeirLaboratory of Asthma and Lung Inflammation, Pulmonary Branch, National Heart, Lung, and Blood Institute, Bethesda, Md.
Or Kalchiem-DekelLaboratory of Asthma and Lung Inflammation, Pulmonary Branch, National Heart, Lung, and Blood Institute, Bethesda, Md.
Patricia TheardLaboratory of Asthma and Lung Inflammation, Pulmonary Branch, National Heart, Lung, and Blood Institute, Bethesda, Md.
Martin P PlayfordSection on Inflammation and Cardiometabolic Diseases, National Heart, Lung, and Blood Institute, Bethesda, Md.
Mario StylianouOffice of Biostatistics Research, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md.
Wendy FitzgeraldSection on Intercellular Interactions, National Institute of Child Health and Development, National Institutes of Health, Bethesda, Md.
Alan T RemaleyLipoprotein Metabolism Laboratory, National Heart, Lung, and Blood Institute, Bethesda, Md.
Stewart J LevineLaboratory of Asthma and Lung Inflammation, Pulmonary Branch, National Heart, Lung, and Blood Institute, Bethesda, Md. Electronic address: levines@nhlbi.nih.gov.
National Heart Lung and Blood Institute · USNational Institutes of Health · US

Funding

Fiberoptic Bronchoscopy in Patients with AsthmaZIAHL006197 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI LEVINE, STEWART · 2015 to 2024
$14.8M
Characterizing the Role of Apolipoprotein Receptors in Asthma PathogenesisZIAHL006055 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI LEVINE, STEWART · 2010 to 2024
$7.8M
Intramural NIH HHS ZIA HL006055Intramural NIH HHS ZIA HL006197
6 · The paper itself

Abstract

rationaleSerum amyloid A (SAA) is bound to high-density lipoproteins (HDL) in blood. Although SAA is increased in the blood of patients with asthma, it is not known whether this modifies asthma severity.

objectiveWe sought to define the clinical characteristics of patients with asthma who have high SAA levels and assess whether HDL from SAA-high patients with asthma is proinflammatory.

methodsSAA levels in serum from subjects with and without asthma were quantified by ELISA. HDLs isolated from subjects with asthma and high SAA levels were used to stimulate human monocytes and were intravenously administered to BALB/c mice.

resultsAn SAA level greater than or equal to 108.8 μg/mL was defined as the threshold to identify 11% of an asthmatic cohort (n = 146) as being SAA-high. SAA-high patients with asthma were characterized by increased serum C-reactive protein, IL-6, and TNF-α; older age; and an increased prevalence of obesity and severe asthma. HDL isolated from SAA-high patients with asthma (SAA-high HDL) had an increased content of SAA as compared with HDL from SAA-low patients with asthma and induced the secretion of IL-6, IL-1β, and TNF-α from human monocytes via a formyl peptide receptor 2/ATP/P2X purinoceptor 7 axis. Intravenous administration to mice of SAA-high HDL, but not normal HDL, induced systemic inflammation and amplified allergen-induced neutrophilic airway inflammation and goblet cell metaplasia.

conclusionsSAA-high patients with asthma are characterized by systemic inflammation, older age, and an increased prevalence of obesity and severe asthma. HDL from SAA-high patients with asthma is proinflammatory and, when intravenously administered to mice, induces systemic inflammation, and amplifies allergen-induced neutrophilic airway inflammation. This suggests that systemic inflammation induced by SAA-high HDL may augment disease severity in asthma.

Indexed as

AsthmaLipoproteins, HDLAllergensAnimalsHumansInflammationInterleukin-6MiceObesitySerum Amyloid A ProteinTumor Necrosis Factor-alphaAllergensInterleukin-6Lipoproteins, HDLSerum Amyloid A ProteinTumor Necrosis Factor-alphaAsthmahigh-density lipoproteinsinflammationneutrophilsserum amyloid A

Identifiers

PMID38092139
PMCPMC10999351
OpenAlexW4389581261

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.