ArticleNature2024
GDF15 linked to maternal risk of nausea and vomiting during pregnancy.
Registry-linked trialOpen access · hybridAbstract read
In one paragraph
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07129473 (Hyperemesis Gravidarum Risk Reduction With Metformin), which is not on this map. Cited by 94 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
94citing papers in PubMed, 3 pooled it
43.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
NCT07129473 phase1 / phase2recruitingnot on this mapstarted 2026, after this paper: background citation
Hyperemesis Gravidarum Risk Reduction With Metformin
Who cites it
94 citing papers in PubMed, 3 syntheses or guidelines pooled it, 173 citations in OpenAlex.
- Multi-ancestry genome-wide association study of severe pregnancy nausea and vomiting.Nature genetics · 2026Pooled it
- Features of nausea and vomiting in pregnancy as predictive factors of post-partum depression: a systematic review.BMC pregnancy and childbirth · 2025Pooled it
- Genome-wide association study of nausea and vomiting during pregnancy in Japan: the TMM BirThree Cohort Study.BMC pregnancy and childbirth · 2024Pooled it
- Randomized Multicenter Trial of Acupressure in Patients Undergoing Moderately to Highly Emetogenic Chemotherapy.Clinical journal of oncology nursing · 2025Trial
- Exploration of treatment strategies and susceptibility gene of postoperative nausea and vomiting in breast cancer patients: a randomised controlled trial.Breast cancer (Tokyo, Japan) · 2024Trial
- Low-Dose Prophylactic Oral Iron Supplementation (Ferrous Fumarate, Ferrous Bisglycinate, and Ferrous Sulphate) in Pregnancy Is Not Associated With Clinically Significant Gastrointestinal Complaints: Results From Two Randomized Studies.Journal of pregnancy · 2024Trial
- Article
- Hyperemesis Gravidarum and the Genetics of Growth Differentiation Factor 15 (GDF-15): A Case Report.Cureus · 2026Article
- Novel Endocrine Signaling Axis in Cardiovascular-Kidney-Metabolic Syndrome: Interactions and Therapeutic Potential of FGF21 and GDF15.Journal of cellular biochemistry · 2026Review
- Genome-wide association analyses of gestational phenotypes identify context-specific genetic effects.Nature genetics · 2026Article
- The Therapeutic Landscape of Nausea and Vomiting of Pregnancy and Hyperemesis Gravidarum: Five Decades of Evolving Treatment and Supportive Care.Medical sciences (Basel, Switzerland) · 2026Review
- Functional segregation of body-brain signals in the area postrema.bioRxiv : the preprint server for biology · 2026Article
- Article
- Article
- De novo and scaffold-based design of GDF15 binders for cancer cachexia diagnostics and therapeutics.Experimental & molecular medicine · 2026Article
- Transient changes in body weight and behavior during the placentation period in non-human primates and rodents.Scientific reports · 2026Article
- Functional characterization of the GWAS lead SNP rs888663 and effects of GDF15 SNPs on GDF15 levels in gestational hypertension and preeclampsia.Molecular biology reports · 2026Article
- A GDF-15-GFRAL axis controls autoimmune T cell responses during neuroinflammation.Nature immunology · 2026Article
- GDF15 in Patients with Autoimmune Primary Adrenal Insufficiency.International journal of molecular sciences · 2026Article
- Utilizing offspring genotype-by-proxy Mendelian randomization to investigate the causal effect of offspring perinatal traits on maternal health.International journal of epidemiology · 2026Article
34 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
43 authors at 9 institutions in 4 countries.
M Fejzo *Center for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0001-6800-687X
N Rocha *Medical Research Council (MRC) Metabolic Diseases Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
I Cimino *Medical Research Council (MRC) Metabolic Diseases Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.ORCID 0000-0003-1397-5408
S M Lockhart *Medical Research Council (MRC) Metabolic Diseases Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.ORCID 0000-0003-2092-4350
C J Petry *Medical Research Council (MRC) Metabolic Diseases Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.ORCID 0000-0002-6642-9825
R G KayMedical Research Council (MRC) Metabolic Diseases Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.ORCID 0000-0002-3827-8687
K BurlingMedical Research Council (MRC) Metabolic Diseases Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
P BarkerMedical Research Council (MRC) Metabolic Diseases Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
A L GeorgePeptidomics and Proteomics Core Facility, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.ORCID 0000-0002-6782-1626
N YasaraDepartment of Paediatrics, Faculty of Medicine, University of Kelaniya, Thalagolla Road, Ragama, Sri Lanka.ORCID 0000-0002-1480-4849
A PremawardhenaAdolescent and Adult Thalassaemia Care Center (University Medical Unit), North Colombo Teaching Hospital, Kadawatha, Sri Lanka.
S GongDepartment of Obstetrics and Gynaecology, University of Cambridge, NIHR Cambridge Biomedical Research Centre, Cambridge, UK.ORCID 0000-0001-5796-4423
E CookDepartment of Obstetrics and Gynaecology, University of Cambridge, NIHR Cambridge Biomedical Research Centre, Cambridge, UK.
D RimmingtonMedical Research Council (MRC) Metabolic Diseases Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
K RainbowMedical Research Council (MRC) Metabolic Diseases Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
D J WithersMedical Research Council (MRC) Metabolic Diseases Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
V CortessisDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0002-2339-1089
P M MullinDepartment of Obstetrics and Gynaecology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
K W MacGibbonHyperemesis Education and Research Foundation, Clackamas, OR, USA.ORCID 0000-0002-6534-3114
E JinDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
A KamDepartment of Obstetrics and Gynaecology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.ORCID 0009-0009-0335-1571
A CampbellCentre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.ORCID 0000-0003-0198-5078
O PolasekFaculty of Medicine, University of Split, Split, Croatia.
G TzonevaRegeneron Genetics Center, Tarrytown, NY, USA.
F M GribbleMedical Research Council (MRC) Metabolic Diseases Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
G S H YeoMedical Research Council (MRC) Metabolic Diseases Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
B Y H LamMedical Research Council (MRC) Metabolic Diseases Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
V SaudekMedical Research Council (MRC) Metabolic Diseases Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.ORCID 0000-0003-4980-9057
I A HughesDepartment of Paediatrics, University of Cambridge, Cambridge, UK.
K K OngDepartment of Paediatrics, University of Cambridge, Cambridge, UK.ORCID 0000-0003-4689-7530
J R B PerryMedical Research Council (MRC) Metabolic Diseases Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.ORCID 0000-0001-6483-3771
A Sutton ColeDepartment of Obstetrics and Gynaecology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
M BaumgartenDepartment of Obstetrics and Gynaecology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
P WelshSchool of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.ORCID 0000-0002-7970-3643
N SattarSchool of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.ORCID 0000-0002-1604-2593
G C S Smith *Department of Obstetrics and Gynaecology, University of Cambridge, NIHR Cambridge Biomedical Research Centre, Cambridge, UK.ORCID 0000-0003-2124-0997
D S Charnock-Jones *Department of Obstetrics and Gynaecology, University of Cambridge, NIHR Cambridge Biomedical Research Centre, Cambridge, UK.ORCID 0000-0002-2936-4890
A P Coll *Medical Research Council (MRC) Metabolic Diseases Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
C L Meek *Medical Research Council (MRC) Metabolic Diseases Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
S Mettananda *Department of Paediatrics, Faculty of Medicine, University of Kelaniya, Thalagolla Road, Ragama, Sri Lanka.ORCID 0000-0002-0760-0418
C Hayward *Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.ORCID 0000-0002-9405-9550
N Mancuso *Center for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0002-9352-5927
S O'Rahilly *Medical Research Council (MRC) Metabolic Diseases Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK. so104@medschl.cam.ac.uk.ORCID 0000-0003-2199-4449
University of Cambridge · GBUniversity of Southern California · USCambridge University Hospitals NHS Foundation Trust · GBUniversity of Kelaniya · LKEdinburgh Cancer Research · GBUniversity of Glasgow · GBEducation & Research Foundation · USRegeneron (United States) · USUniversity of Split · HR
Funding
Statistical Methods for Integrative Genomics in CancerP01CA196569 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Paul Marjoram · 2016 to 2026
$25.5MCharacterizing the evolutionary architecture of complex disease within and across diverse populationsR01HG012133 · NHGRI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MANCUSO, NICHOLAS · 2021 to 2025
$3.6MHaplotype-aware models of gene and isoform expression with application to genetic studies of disease in diverse populationsR01GM140287 · NIGMS · SEATTLE CHILDREN'S HOSPITAL · PI GAMAZON, ERIC R, MOHAMMADI, PEJMAN · 2021 to 2024
$2.8MMedical Research Council G1001995Medical Research Council MC_UU_00006/2Medical Research Council MC_UU_00007/10Medical Research Council MC_UU_00014/1Medical Research Council MC_UU_00014/3Medical Research Council MC_UU_00014/5Medical Research Council MC_UU_12015/2Medical Research Council MR/M009041/1NCI NIH HHS P01 CA196569NHGRI NIH HHS R01 HG012133NIGMS NIH HHS R01 GM140287Wellcome Trust
Abstract
GDF15, a hormone acting on the brainstem, has been implicated in the nausea and vomiting of pregnancy, including its most severe form, hyperemesis gravidarum (HG), but a full mechanistic understanding is lacking
Indexed as
Growth Differentiation Factor 15Hyperemesis GravidarumNauseaVomitingAnimalsbeta-ThalassemiaFemaleFetusHormonesHumansMicePlacentaPregnancyGDF15 protein, humanGrowth Differentiation Factor 15Hormones
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
NCT07129473ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.