ArticleImmunity2024
trans-Endothelial neutrophil migration activates bactericidal function via Piezo1 mechanosensing.
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Article in Immunity, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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59citing papers in PubMed
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59 citing papers in PubMed, 67 citations in OpenAlex.
- Mechano-immunomodulatory biomaterials: From immune mechanosensing to translational design.Bioactive materials · 2026Review
- Recursive feedback between Piezo1 conformation and membrane mechanics drives self-organization into finite clusters.bioRxiv : the preprint server for biology · 2026Article
- Mechanical stress promotes excessive NETs and exacerbates acute lung injury via Piezo1-mediated mitochondrial dysfunction.Redox biology · 2026Article
- Pulmonary Capillary Confinement Shapes A Motile Anuclear Neutrophil State.Research square · 2026Article
- Piezo1 channel: structure, mechanogating mechanism, functions, diseases and therapeutic strategy.Molecular biomedicine · 2026Review
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- Alveolar macrophage-neutrophil crosstalk in acute lung injury: mechanisms, feedback loops, and therapeutic opportunities.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Review
- Piezo1 in the central nervous system: decoding the mechanical signature of neuroinflammation.Journal of neuroinflammation · 2026Review
- Neutrophils exhibit distinct migration phenotypes that are modulated by transendothelial migration.Communications biology · 2026Article
- Innate Immune Function of Neutrophil Cytoplasts Generated Post-Vital NETosis.Research square · 2026Article
- ERG-deficient endothelium identifies IL-8/CXCR2 axis as a therapeutic target for resolving neutrophilic lung vascular injury.JCI insight · 2026Article
- Chemical and Mechanical Regulation of Leukocyte Migration.Cold Spring Harbor perspectives in biology · 2026Review
- Transient mechanical activation of the Piezo1 channel facilitates ex vivo expansion of hematopoietic stem cells.Cell research · 2026Article
- Shaping neutrophil morphology and function: the importance of a segmented nucleus.Nature reviews. Immunology · 2026Review
- Megakaryocyte and platelet thrombospondin-1 regulates matrix remodeling by stabilizing basement membrane COL6A1 in lung injury.Nature communications · 2026Article
- Oscillatory shear stress-driven endothelial-to-mesenchymal transition: a critical mechanical signal transduction mechanism in atherosclerosis progression.Cell death discovery · 2026Review
- A functional and robust cellular model for high-throughput screening of piezo1 modulators.Scientific reports · 2026Article
- Piezo1-Targeted Magnetoacoustic Nanobubbles Rescue Alzheimer's Pathology by Electromechanical Neuromodulation and Amyloid-β Clearance.ACS nano · 2026Article
- Review
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Authors and funding
16 authors at 3 institutions in 1 country.
Amitabha MukhopadhyayDepartment of Pharmacology and Regenerative Medicine and The Center for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL 60612, USA.
Yoshikazu TsukasakiDepartment of Pharmacology and Regenerative Medicine and The Center for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL 60612, USA.
Wan Ching ChanDepartment of Pharmacology and Regenerative Medicine and The Center for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL 60612, USA.
Jonathan P LeDepartment of Pharmacology and Regenerative Medicine and The Center for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL 60612, USA.
Man Long KwokDepartment of Pharmacology and Regenerative Medicine and The Center for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL 60612, USA.
Jian ZhouRichard and Loan Hill Department of Biomedical Engineering, University of Illinois, Chicago, IL 60612, USA.
Viswanathan NatarajanDepartment of Pharmacology and Regenerative Medicine and The Center for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL 60612, USA; Department of Medicine, University of Illinois College of Medicine, Chicago, IL 60612, USA.
Nima MostafazadehRichard and Loan Hill Department of Biomedical Engineering, University of Illinois, Chicago, IL 60612, USA.
Mark Maienschein-ClineResearch Informatics Core, Research Resources Center, University of Illinois College of Medicine, Chicago, IL 60612, USA.
Ian PapautskyRichard and Loan Hill Department of Biomedical Engineering, University of Illinois, Chicago, IL 60612, USA.
Chinnaswamy TiruppathiDepartment of Pharmacology and Regenerative Medicine and The Center for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL 60612, USA.
Zhangli PengRichard and Loan Hill Department of Biomedical Engineering, University of Illinois, Chicago, IL 60612, USA.
Jalees RehmanDepartment of Pharmacology and Regenerative Medicine and The Center for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL 60612, USA.
Balaji GaneshFlow Cytometry Core, Research Resources Center, University of Illinois College of Medicine, Chicago, IL 60612, USA.
Yulia KomarovaDepartment of Pharmacology and Regenerative Medicine and The Center for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL 60612, USA. Electronic address: ykomarov@uic.edu.
Asrar B MalikDepartment of Pharmacology and Regenerative Medicine and The Center for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL 60612, USA. Electronic address: abmalik@uic.edu.
Illinois College · USUniversity of Illinois Chicago · USUniversity of Illinois Urbana-Champaign · US
Funding
TRPC6 Regulation of Lung Endothelial Barrier FunctionP01HL060678 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MALIK, ASRAR B. · 2000 to 2020
$40.1MStrengthening Stakeholder Engagement in Human Research Protections.UL1TR002003 · NCATS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI KARNIK, NIRANJAN SUBHASH, MERMELSTEIN, ROBIN J. · 2016 to 2024
$33.7MTRAINING PROGRAM IN LUNG BIOLOGY AND PATHOBIOLOGYT32HL007829 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DOLLY MEHTA · 1995 to 2026
$15.6MThe Lung Endothelium as an Instructive Niche for the Innate Immune System during Vascular InjuryP01HL160469 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DOLLY MEHTA · 2022 to 2026
$14.0MTHROMBIN-INDUCED PULMONARY VASCULAR PERMEABILITYR01HL045638 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI KOMAROVA, YULIA A · 1991 to 2025
$12.0MSynthetic Biology and Optogenetics CoreP01HL151327 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI REHMAN, JALEES · 2021 to 2025
$11.8MMechanisms and Treatment of SARS-CoV-2 induced Lung Endothelial InjuryR01HL162308 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI REHMAN, JALEES, RICHNER, JUSTIN · 2022 to 2025
$2.9MiPSC-Derived Vascularized Human Lung Organoids and Interaction Between Lung Endothelial Cells and Alveolar Epithelial CellsR01HL163978 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI KADUR LAKSHMINARASIM, PREETISH, REHMAN, JALEES · 2022 to 2025
$2.9MNanoparticle Targeting of Neutrophil Subpopulations in Inflammatory Lung InjuryR01HL149300 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MALIK, ASRAR B., REHMAN, JALEES · 2019 to 2022
$2.4MAmplification Mechanisms of Lung Endothelial Inflammation During Acute Lung InjuryR01HL152515 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI REHMAN, JALEES · 2021 to 2024
$2.3MNCATS NIH HHS UL1 TR002003NHLBI NIH HHS P01 HL060678NHLBI NIH HHS P01 HL151327NHLBI NIH HHS P01 HL160469NHLBI NIH HHS R01 HL045638NHLBI NIH HHS R01 HL149300NHLBI NIH HHS R01 HL152515NHLBI NIH HHS R01 HL162308NHLBI NIH HHS R01 HL163978NHLBI NIH HHS T32 HL007829
Abstract
The regulation of polymorphonuclear leukocyte (PMN) function by mechanical forces encountered during their migration across restrictive endothelial cell junctions is not well understood. Using genetic, imaging, microfluidic, and in vivo approaches, we demonstrated that the mechanosensor Piezo1 in PMN plasmalemma induced spike-like Ca
Indexed as
Cell MovementLungMechanotransduction, CellularNeutrophilsAnimalsBlood Bactericidal ActivityCell MembraneIon ChannelsMiceIon ChannelsPiezo1 protein, mousecalcium signalingmechanical signalingneutrophilNox4phagocytosisPiezo1pneumonia
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.