Evidence map›Paper›PMID 38091947›Full record

ArticleImmunity2023

Sex-biased gut dopamine signaling in multiple sclerosis.

Shui Yu, Melody Y Zeng

Open access · bronzeAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunity, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Shui YuGale and Ira Drukier Institute for Children's Health, Weill Cornell Medicine, New York, NY 10065, USA; Department of Pediatrics, Weill Cornell Medicine, New York, NY 10065, USA.
Melody Y ZengGale and Ira Drukier Institute for Children's Health, Weill Cornell Medicine, New York, NY 10065, USA; Department of Pediatrics, Weill Cornell Medicine, New York, NY 10065, USA; Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School, New York, NY 10065, USA. Electronic address: myz4001@med.cornell.edu.
Cornell University · US

Funding

Megakaryocyte regulation by the gut microbiomeR01HL169989 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI Melody Y Zeng · 2023 to 2026
$2.6M
Immune regulation by the gut microbiome at the maternal-fetal interfaceR01HD110118 · NICHD · WEILL MEDICAL COLL OF CORNELL UNIV · PI ZENG, MELODY Y · 2022 to 2024
$1.3M
Role of gut microbiota-induced IgG in enteric host defenseK01DK114376 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI ZENG, MELODY Y · 2018 to 2022
$758k
Dissecting the interplay between immunoglobulin G and the gut microbiome in cancer progression and metastasisR21CA270998 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI MATEI, IRINA, ZENG, MELODY Y · 2023 to 2024
$426k
NCI NIH HHS R21 CA270998NHLBI NIH HHS R01 HL169989NICHD NIH HHS R01 HD110118NIDDK NIH HHS K01 DK114376
6 · The paper itself

Abstract

Multiple sclerosis shows a strong sex bias, with unclear mechanisms. In this issue of Immunity, Peng et al. elucidate a female-biased increase in intestinal dopamine signaling that diminishes protective Lactobacillus and exacerbates inflammation in a mouse model of multiple sclerosis.

Indexed as

Multiple SclerosisAnimalsDopamineFemaleInflammationMiceSexismDopamine

Identifiers

PMID38091947
PMCPMC10908588
OpenAlexW4389615193

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.