ArticleScience translational medicine2023
Short-course combination treatment for experimental chronic Chagas disease.
Open access · hybridAbstract read
In one paragraph
Article in Science translational medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 22 citations in OpenAlex.
- Visceral leishmaniasis: an integrated review of resistance mechanisms, host immunometabolism, and next generation therapeutics.Inflammopharmacology · 2026Review
- IID432, a parasite-selective topoisomerase II inhibitor, achieves rapid single-dose parasite clearance in a murine chronic Chagas model.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Overcoming Trypanosoma cruzi persistence with a mechanistically distinct drug combination.npj antimicrobials and resistance · 2026Article
- A strategic discovery roadmap towards high-quality leads and drug development candidates for kinetoplastid diseases. Part 2: from molecule to confirmed hit.The Journal of antimicrobial chemotherapy · 2026Review
- Advances and challenges in the search for new treatments for Chagas disease.Memorias do Instituto Oswaldo Cruz · 2026Review
- Untargeted metabolomics for triaging of cytochrome b inhibitors during Chagas' disease drug discovery.PLoS neglected tropical diseases · 2026Article
- Paroxetine activity against Trypanosoma cruzi: in vitro and in vivo studies.Memorias do Instituto Oswaldo Cruz · 2026Article
- Interventions for Neglected Diseases Caused by Kinetoplastid Parasites: A One Health Approach to Drug Discovery, Development, and Deployment.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Structure-activity relationships of 1,5-dihydro-2RSC medicinal chemistry · 2025Article
- Antitrypanosomal quinazolines targeting lysyl-tRNA synthetase show partial efficacy in a mouse model of acute Chagas disease.Science translational medicine · 2025Article
- Amiodarone and Ravuconazole Combination Potentiates Chemotherapy against Drug-Resistant Trypanosoma cruzi Strains.ACS omega · 2025Article
- Progress and Prospects of Triazoles in Advanced Therapies for Parasitic Diseases.Tropical medicine and infectious disease · 2025Review
- System-based insights into parasitological and clinical treatment failure in Chagas disease.mSystems · 2025Review
- Exploration of innovative drug repurposing strategies for combating human protozoan diseases: Advances, challenges, and opportunities.Journal of pharmaceutical analysis · 2025Review
- In vitro and in vivo studies on the activity and selectivity of butoconazole in experimental infection by Trypanosoma cruzi.Memorias do Instituto Oswaldo Cruz · 2025Article
- Animal models for exploring Chagas disease pathogenesis and supporting drug discovery.Clinical microbiology reviews · 2024Review
- Oral Chagas disease outbreak by bacaba juice ingestion: A century after Carlos Chagas' discovery, the disease is still hard to manage.PLoS neglected tropical diseases · 2024Article
- A panel of phenotypically and genotypically diverse bioluminescent:fluorescent Trypanosoma cruzi strains as a resource for Chagas disease research.PLoS neglected tropical diseases · 2024Article
- Drug screening and development cascade for Chagas disease: an update of in vitro and in vivo experimental models.Memorias do Instituto Oswaldo Cruz · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
30 authors at 6 institutions in 4 countries.
Silvia GonzálezGlobal Health Medicines R&D, GSK, Tres Cantos, Madrid, Spain.ORCID 0009-0005-6551-0209
Richard J WallWellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, UK.ORCID 0000-0003-3487-3187
John ThomasWellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, UK.
Stephanie BraillardDrugs for Neglected Disease Initiative (DNDi), Geneva, Switzerland.ORCID 0000-0002-6354-3059
Gino BrunoriGlobal Investigative Safety, GSK, Ware, UK.
Isabel Camino DíazDiscovery DMPK, GSK Tres Cantos, Madrid, Spain.ORCID 0009-0005-4024-6894
Juan CantizaniGlobal Health Medicines R&D, GSK, Tres Cantos, Madrid, Spain.
Sandra CarvalhoWellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, UK.ORCID 0000-0001-6695-1683
Pablo Castañeda CasadoDiscovery DMPK, GSK Tres Cantos, Madrid, Spain.ORCID 0000-0002-0514-7306
Eric ChatelainDrugs for Neglected Disease Initiative (DNDi), Geneva, Switzerland.ORCID 0000-0002-3158-7743
Ignacio CotilloGlobal Health Medicines R&D, GSK, Tres Cantos, Madrid, Spain.ORCID 0009-0008-5477-8498
Jose M FiandorGlobal Health Medicines R&D, GSK, Tres Cantos, Madrid, Spain.
Amanda Fortes FranciscoLondon School for Hygiene and Tropical Medicine, London, UK.ORCID 0000-0002-3475-8130
David GrimsditchGlobal Investigative Safety, GSK, Ware, UK.
Martine KeenanEpichem, Bentley, Australia.ORCID 0009-0003-1218-0520
John M KellyLondon School for Hygiene and Tropical Medicine, London, UK.ORCID 0000-0003-4305-5258
Albane KesslerGlobal Health Medicines R&D, GSK, Tres Cantos, Madrid, Spain.
Chiara LuiseWellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, UK.
Jon J LyonGlobal Investigative Safety, GSK, Ware, UK.ORCID 0009-0002-6038-7799
Lorna MacLeanWellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, UK.ORCID 0000-0002-5691-5117
Maria MarcoGlobal Health Medicines R&D, GSK, Tres Cantos, Madrid, Spain.ORCID 0000-0002-2442-0021
J Julio MartinGlobal Health Medicines R&D, GSK, Tres Cantos, Madrid, Spain.ORCID 0000-0003-1887-0859
Maria S Martinez MartinezDiscovery DMPK, GSK Tres Cantos, Madrid, Spain.ORCID 0000-0001-7894-2135
Christy PatersonWellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, UK.ORCID 0009-0009-4264-4860
Kevin D ReadWellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, UK.ORCID 0000-0002-8536-0130
Angel Santos-VillarejoDiscovery DMPK, GSK Tres Cantos, Madrid, Spain.
Fabio ZuccottoWellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, UK.ORCID 0000-0002-3888-7423
Susan WyllieWellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, UK.ORCID 0000-0001-8810-5605
Tim J MilesGlobal Health Medicines R&D, GSK, Tres Cantos, Madrid, Spain.ORCID 0000-0001-7407-7404
Manu De RyckerWellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, UK.ORCID 0000-0002-3171-3519
Wellcome Centre for Anti-Infectives Research · GBGlaxoSmithKline (Spain) · ESHealth and Safety Executive · GBDrugs for Neglected Diseases Initiative · CHLondon School of Hygiene & Tropical Medicine · GBBentley University · US
Funding
Wellcome Trust 100194Wellcome Trust 105021Wellcome Trust 203134Wellcome Trust 203134/Z/16/ZWellcome Trust 204672Wellcome Trust 218448
Abstract
Chagas disease, caused by the protozoan parasite
Indexed as
Chagas DiseaseParasitesTrypanocidal AgentsTrypanosoma cruziAnimalsCytochromes bHumansNitroimidazolesbenzonidazoleCytochromes bNitroimidazolesTrypanocidal Agents
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.