ArticleScience advances2023
Myeloid/natural killer (NK) cell precursor acute leukemia as a distinct leukemia type.
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Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
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Who cites it
4 citing papers in PubMed, 3 citations in OpenAlex.
- Integrated profiling of RUNX3 in intratumoral NK cells activity through bulk and single-cell transcriptomic analysis.Frontiers in immunology · 2026Article
- Multi-omics analysis identifies an M-MDSC-like immunosuppressive phenotype in lineage-switched AML with KMT2A rearrangement.Nature communications · 2025Article
- Successful Cord Blood Transplantation for Myeloid/Natural Killer Precursor Acute Leukemia: A Case Report and Literature Review.Internal medicine (Tokyo, Japan) · 2025Review
- Acute myeloid leukemia with aLeukemia research reports · 2024Article
Corrections and comments
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Authors and funding
53 authors at 20 institutions in 1 country.
Akira NishimuraDepartment of Pediatrics and Developmental Biology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.ORCID 0000-0002-9127-807X
Kazuaki YokoyamaDepartment of Hematology/Oncology, Research Hospital, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Takuya NarutoDepartment of Pediatrics and Developmental Biology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.ORCID 0000-0002-5590-8126
Chika YamagishiDepartment of Pediatrics and Developmental Biology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.ORCID 0000-0001-5501-6390
Toshihiko ImamuraDepartment of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.ORCID 0000-0002-5727-4470
Hiroto NakazonoDepartment of Pediatrics and Developmental Biology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.
Shunsuke KimuraDepartment of Pediatrics, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan.ORCID 0000-0002-2158-467X
Mieko ItoDivision of Hematology/Oncology, Kanagawa Children's Medical Center, Yokohama, Japan.
Maiko SagisakaDivision of Hematology/Oncology, Kanagawa Children's Medical Center, Yokohama, Japan.
Yukie TanakaResearch Core, Institute of Research, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.
Jinhua PiaoDepartment of Pediatrics and Developmental Biology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.ORCID 0000-0002-8200-4659
Yui NamikawaDepartment of Pediatrics and Developmental Biology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.
Masakatsu YanagimachiDivision of Hematology/Oncology, Kanagawa Children's Medical Center, Yokohama, Japan.
Takeshi IsodaDepartment of Pediatrics and Developmental Biology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.ORCID 0000-0003-3349-3705
Akinori KanaiDepartment of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.ORCID 0000-0003-1555-6768
Hirotaka MatsuiDepartment of Molecular Laboratory Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.ORCID 0000-0002-6266-3227
Tomoya IsobeDepartment of Pediatrics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan .ORCID 0000-0002-3487-3307
Aiko Sato-OtsuboDepartment of Pediatrics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan .ORCID 0000-0002-2528-0702
Naoko HiguchiDepartment of Pediatrics, University of Occupational and Environmental Health, Kitakyushu, Japan.
Akiko TakadaDepartment of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Haruna OkunoDepartment of Pediatrics, Gunma University Hospital, Maebashi, Japan.
Shoji SaitoDepartment of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan.ORCID 0000-0003-3866-3582
Shuhei KarakawaDepartment of Pediatrics, Hiroshima University Hospital, Hiroshima, Japan.ORCID 0000-0003-1853-4759
Shogo KobayashiDepartment of Pediatric Oncology, Fukushima Medical University Hospital, Fukushima, Japan.ORCID 0000-0003-2305-942X
Daisuke HasegawaDepartment of Pediatrics, St. Luke's International Hospital, Tokyo, Japan.ORCID 0000-0002-9446-9568
Hiroyuki FujisakiDepartment of Pediatric Hematology and Oncology, Osaka City General Hospital, Osaka, Japan.ORCID 0009-0007-6162-4828
Daiichiro HasegawaDepartment of Hematology and Oncology, Hyogo Prefectural Kobe Children's Hospital, Kobe, Japan.
Kazutoshi KoikeDivision of Pediatric Hematology and Oncology, Ibaraki Children's Hospital, Mito, Japan.
Takashi KoikeDepartment of Pediatrics, Tokai University School of Medicine, Isehara, Japan.
Shinya RaiDepartment of Hematology and Rheumatology, Faculty of Medicine, Kindai University, Osakasayama, Japan.ORCID 0000-0003-3929-9751
Katsutsugu UmedaDepartment of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.ORCID 0000-0002-6844-2011
Hideki SanoDepartment of Pediatric Oncology, Fukushima Medical University Hospital, Fukushima, Japan.ORCID 0000-0002-3242-6917
Yujin SekinakaDepartment of Pediatrics, National Defense Medical College, Tokorozawa, Japan.ORCID 0000-0002-2497-3419
Atsushi OgawaDepartment of Pediatrics, Niigata Cancer Center Hospital, Niigata, Japan.ORCID 0009-0007-3909-7902
Akitoshi KinoshitaDepartment of Pediatrics, St. Marianna University School of Medicine, Kawasaki, Japan.ORCID 0000-0001-6365-3381
Norio ShibaDepartment of Pediatrics, Yokohama City University Graduate School of Medicine, Yokohama, Japan.ORCID 0000-0003-0392-9221
Mizuka MikiDepartment of Pediatrics, Hiroshima Red Cross Hospital and Atomic-Bomb Survivors Hospital, Hiroshima, Japan.
Fumihiko KimuraDivision of Hematology, Department of Internal Medicine, National Defense Medical College, Tokorozawa, Japan.ORCID 0000-0001-6223-9904
Hideki NakayamaDepartment of Pediatrics, Kyushu Cancer Center, Fukuoka, Japan.
Yozo NakazawaDepartment of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan.ORCID 0000-0003-0793-815X
Takashi TagaLeukemia/Lymphoma Committee of Japanese Society of Pediatric Hematology and Oncology, Tokyo, Japan.ORCID 0000-0003-0525-4766
Tomohiko TakiLeukemia/Lymphoma Committee of Japanese Society of Pediatric Hematology and Oncology, Tokyo, Japan.
Souichi AdachiLeukemia/Lymphoma Committee of Japanese Society of Pediatric Hematology and Oncology, Tokyo, Japan.
Atsushi ManabeLeukemia/Lymphoma Committee of Japanese Society of Pediatric Hematology and Oncology, Tokyo, Japan.
Katsuyoshi KohLeukemia/Lymphoma Committee of Japanese Society of Pediatric Hematology and Oncology, Tokyo, Japan.ORCID 0000-0002-0476-4978
Yasushi IshidaLeukemia/Lymphoma Committee of Japanese Society of Pediatric Hematology and Oncology, Tokyo, Japan.ORCID 0000-0002-4996-6581
Junko TakitaDepartment of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.ORCID 0000-0002-2452-6520
Fumihiko IshikawaLaboratory for Human Disease Models, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.ORCID 0000-0002-8717-1237
Hiroaki GotoDivision of Hematology/Oncology, Kanagawa Children's Medical Center, Yokohama, Japan.ORCID 0000-0001-6737-1509
Tomohiro MorioDepartment of Pediatrics and Developmental Biology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.ORCID 0000-0002-9259-1025
Shuki MizutaniDepartment of Pediatrics and Developmental Biology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.ORCID 0000-0001-7930-4960
Arinobu TojoDepartment of Hematology/Oncology, Research Hospital, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.ORCID 0000-0001-9016-1948
Masatoshi TakagiDepartment of Pediatrics and Developmental Biology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.ORCID 0000-0002-7580-9184
Tokyo Medical and Dental University · JPKanagawa Children's Medical Center · JPKyoto University · JPUniversity of Tokyo Hospital · JPFukushima Medical University Hospital · JPNational Defense Medical College · JPShinshu University · JPSt. Luke's International Hospital · JPEhime Prefectural Central Hospital · JPGunma University Hospital · JPHiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital · JPHiroshima University · JPHiroshima University Hospital · JPHokkaido University · JPIbaraki Children's Hospital · JPKindai University · JPKumamoto University · JPKyorin University · JPKyoto Prefectural University of Medicine · JPNational Hospital Organization Kyushu Cancer Center · JP
Funding
No grant is acknowledged in the PubMed record.
Abstract
Myeloid/natural killer (NK) cell precursor acute leukemia (MNKPL) has been described on the basis of its unique immunophenotype and clinical phenotype. However, there is no consensus on the characteristics for identifying this disease type because of its rarity and lack of defined distinctive molecular characteristics. In this study, multiomics analysis revealed that MNKPL is distinct from acute myeloid leukemia, T cell acute lymphoblastic leukemia, and mixed-phenotype acute leukemia (MPAL), and
Indexed as
AsparaginaseLeukemia, Myeloid, AcuteAcute DiseaseHumansKiller Cells, NaturalRepressor ProteinsTreatment OutcomeTumor Suppressor ProteinsAsparaginaseBCL11B protein, humanRepressor ProteinsTumor Suppressor Proteins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.