Evidence map›Paper›PMID 38091291›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

The mitochondrial ATP synthase is a negative regulator of the mitochondrial permeability transition pore.

Ryan Pekson, Felix G Liang, Joshua L Axelrod, Jaehoon Lee, Dongze Qin, Andre J H Wittig, Victor M Paulino, Min Zheng, Pablo M Peixoto, Richard N Kitsis

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. ATP synthase subunits e and g are essential for CaCell death and differentiation · 2026
    Article
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  20. Hemoglobin as an oxygen gasoreceptor.Acta biochimica Polonica · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Ryan Pekson *Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461.ORCID 0000-0002-1713-2582
Felix G Liang *Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine, Bronx, NY 10461.
Joshua L Axelrod *Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine, Bronx, NY 10461.ORCID 0000-0002-4307-8452
Jaehoon LeeDepartment of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461.ORCID 0009-0009-5622-2941
Dongze QinDepartment of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461.
Andre J H WittigWilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine, Bronx, NY 10461.
Victor M PaulinoWilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine, Bronx, NY 10461.
Min ZhengDepartment of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461.
Pablo M PeixotoDepartment of Natural Sciences, Baruch College and Program in Molecular, Cellular, and Developmental Biology, Graduate Center, City University of New York, New York, NY 10010.ORCID 0000-0001-5953-6027
Richard N KitsisDepartment of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461.ORCID 0000-0003-1395-9694
Albert Einstein College of Medicine · USThe Graduate Center, CUNY · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007288 · NIGMS · YESHIVA UNIVERSITY · PI AKABAS, MYLES H. · 1985 to 2022
$35.6M
TRAINING PROGRAM IN CELLULAR &MOLEC. BIOLOGY &GENETICST32GM007491 · NIGMS · YESHIVA UNIVERSITY · PI QUERY, CHARLES C · 1985 to 2021
$17.0M
Medical Scientist Training ProgramT32GM149364 · NIGMS · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI Myles H. Akabas · 2023 to 2026
$7.5M
Mitochondrial ATP Synthase in Cardiac Biology and DiseaseR01HL157319 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI KITSIS, RICHARD N · 2022 to 2025
$2.9M
Modulation of Mitofusin Activity to Treat Heart DiseaseR01HL159062 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI KITSIS, RICHARD N · 2021 to 2024
$2.6M
Caspase-9 as a nodal point connecting necrotic and apoptotic cell death in myocardial infarctionR01HL164772 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI KITSIS, RICHARD N · 2022 to 2025
$2.5M
Mechanisms of cardiovascular diseaseT32HL144456 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI Carlos Jose Rodriguez, Nicholas E Sibinga · 2019 to 2026
$1.9M
Retraction or reshaping: dissecting the role of mitochondrial ROS in synaptic plasticitySC1GM136609 · NIGMS · BERNARD M. BARUCH COLLEGE · PI PEIXOTO, PABLO M · 2020 to 2023
$1.4M
NHLBI NIH HHS R01 HL157319NHLBI NIH HHS R01 HL159062NHLBI NIH HHS R01 HL164772NHLBI NIH HHS T32 HL144456NIGMS NIH HHS SC1 GM136609NIGMS NIH HHS T32 GM007288NIGMS NIH HHS T32 GM007491NIGMS NIH HHS T32 GM149364
6 · The paper itself

Abstract

The mitochondrial permeability transition pore (mPTP) is a channel in the inner mitochondrial membrane whose sustained opening in response to elevated mitochondrial matrix Ca

Indexed as

Mitochondrial Permeability Transition PoreMitochondrial Proton-Translocating ATPasesAnimalsCalciumCyclophilinsMiceMitochondria, HeartMitochondrial Membrane Transport ProteinsPeptidyl-Prolyl Isomerase FCalciumCyclophilinsMitochondrial Membrane Transport ProteinsMitochondrial Permeability Transition PoreMitochondrial Proton-Translocating ATPasesPeptidyl-Prolyl Isomerase Fmitochondrial ATP synthasemitochondrial permeability transition porenecrosis

Identifiers

PMID38091291
PMCPMC10743364
OpenAlexW4389669102

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.