SynthesisSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2023
Quality of life issues in patients with bone metastases: A systematic review.
Synthesis in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- A novel inflammatory-nutritional nomogram for predicting survival after minimally invasive surgery for spinal metastases: a comparison with the Katagiri and SORG systems.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Challenges in the management of bone metastases: focus on differentiated thyroid cancer and neuroendocrine tumors.Journal of the Endocrine Society · 2026Article
- Psychometric properties and clinical utility of the EORTC QLQ-BM22 in patients with bone metastases: a systematic review.EClinicalMedicine · 2026Review
- Subchondral Insufficiency Fracture of the Femoral Head in a Terminal Cancer Patient Treated by Total Hip Arthroplasty.Journal of orthopaedic case reports · 2026Article
- Study protocol: feasibility and safety of conventional external-beam radiotherapy with an integrated stereotactic lite gross-tumour-volume boost for painful bone metastases: the HYBRID study.Radiation oncology (London, England) · 2025Article
- Evaluating risk factors for skeletal-related events among bone metastases from solid tumors.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2025Article
- Percutaneous microwave ablation of bone lesions: a retrospective cohort study.Insights into imaging · 2025Article
- Timely integration of palliative care into oncology care for patients with bone metastases at the radiotherapy department: A pilot study on acceptability and feasibility.Technical innovations & patient support in radiation oncology · 2025Article
- Overcome the Fear of Exercise in Patients With Bone Metastases: A Qualitative Study on Patients' Perception.Cancer medicine · 2025Article
- Pilot study on the in-vitro effect of radiation therapy on bending stiffness of intramedullary photodynamic implants.Journal of orthopaedic surgery and research · 2024Article
- Review
Corrections and comments
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Authors and funding
26 authors.
Funding
Abstract
introductionBones are frequent sites of metastatic disease, observed in 30-75% of advanced cancer patients. Quality of life (QoL) is an important endpoint in studies evaluating the treatments of bone metastases (BM), and many patient-reported outcome tools are available. The primary objective of this systematic review was to compile a list of QoL issues relevant to BM and its interventions. The secondary objective was to identify common tools used to assess QoL in patients with BM, and the QoL issues they fail to address.
methodsA search was conducted on Ovid MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials databases between 1946 and 27 January 2023 with the keywords "bone metastases", "quality of life", and "patient reported outcomes". Specific QoL issues in original research studies and the QoL tools used were extracted.
resultsThe review identified the QoL issues most prevalent to BM in the literature. Physical and functional issues observed in patients included pain, interference with ambulation and daily activities, and fatigue. Psychological symptoms, such as helplessness, depression, and anxiety were also common. These issues interfered with patients' relationships and social activities. Items not mentioned in existing QoL tools were related to newer treatments of BM, such as pain flare, flu-like symptoms, and jaw pain due to osteonecrosis.
conclusionsThis systematic review highlights that QoL issues for patients with BM have expanded over time due to advances in BM-directed treatments. If they are relevant, additional treatment-related QoL issues identified need to be validated prospectively by patients and added to current assessment tools.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.