Evidence map›Paper›PMID 38091056›Full record

ArticleEuropean radiology2024

Prediction of acute rejection in renal allografts using shear-wave dispersion slope.

Taek Min Kim, Hyungwoo Ahn, Jeong Yeon Cho, Ahram Han, Sang-Il Min, Jongwon Ha, Sang Youn Kim

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Article in European radiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 2 countries.

Taek Min KimDepartment of Radiology, Seoul National University Hospital, Seoul, South Korea.
Hyungwoo AhnDepartment of Radiology, Seoul National University College of Medicine, Seoul, South Korea.
Jeong Yeon ChoDepartment of Radiology, Seoul National University Hospital, Seoul, South Korea.
Ahram HanDepartment of Surgery, Seoul National University College of Medicine, Seoul, South Korea.
Sang-Il MinDepartment of Surgery, Seoul National University College of Medicine, Seoul, South Korea.
Jongwon HaDepartment of Surgery, Seoul National University College of Medicine, Seoul, South Korea.
Sang Youn KimDepartment of Radiology, Seoul National University Hospital, Seoul, South Korea. iwishluv@empas.com.ORCID http://orcid.org/0000-0003-4038-7345
Seoul National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo evaluate the role of shear-wave dispersion slope for predicting renal allograft dysfunction.

methodsWe retrospectively reviewed 128 kidney transplant recipients (median age, 55 years [interquartile range, 43-62 years]; male, 68) who underwent biopsy for allograft evaluation from November 2022 to February 2023. Cortex and renal sinus fat stiffness and shear-wave dispersion slope were obtained at shear-wave elastography (SWE). Cortex-to-sinus stiffness ratio (SR) and dispersion slope ratio (DSR)-related clinical and pathologic factors were evaluated using multivariable linear regression analysis. We conducted univariate and multivariate analyses for multiparametric ultrasound (US) parameters for identifying acute rejection and calculated the area under the receiver operating curve (AUC) values.

resultsOf 128 patients, 31 (24.2%) demonstrated acute rejection. The SR value did not differ between patient groups (1.21 vs. 1.20, p = 0.47). Patients with acute rejection demonstrated a higher DSR than those without rejection (1.4 vs. 1.21, p < 0.01). Interstitial fibrosis and tubular atrophy grade (IFTA; coefficient, 0.11/grade; p = 0.04) and renal transplant and biopsy interval (coefficient, 0.00007/day; p = 0.03) were SR determinant factors, whereas only IFTA grade (coefficient, 0.10/grade; p = 0.01) for DSR. Multivariate analysis revealed mean resistive index (odds ratio [OR] 1.08, 95% confidence interval [CI] 1.02-1.14, p = 0.01) and DSR value (OR 16.0, 95% CI 3.0-85.8, p = 0.001) as independent factors for predicting acute rejection. An AUC of 0.74 for detecting acute rejection was achieved by combining the resistive index and DSR value.

conclusionShear-wave dispersion slope obtained at SWE may help identify renal allograft dysfunction. CLINICAL RELEVANCE STATEMENT: Acute rejection in renal allografts is a major cause of allograft failure, but noninvasive diagnosis is a challenge. Shear-wave dispersion slope can identify acute rejection non-invasively. KEY POINTS: • The interstitial fibrosis and tubular atrophy grade was a determinant factor for stiffness ratio and shear-wave dispersion slope ratio between cortex and renal sinus fat. • Shear-wave dispersion slope ratio between cortex and renal sinus fat could identify acute rejection in renal allografts. • A shear-wave dispersion slope has a potential to reduce unnecessary renal biopsy for evaluating renal allografts.

Indexed as

Elasticity Imaging TechniquesGraft RejectionKidney TransplantationAdultAllograftsBiopsyFemaleHumansKidneyMaleMiddle AgedPredictive Value of TestsRetrospective StudiesAcoustic radiation force impulse imagingGraft rejectionKidney transplantationSonoelastographyViscosity

Identifiers

PMID38091056
OpenAlexW4389711972

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.