Evidence map›Paper›PMID 38090817›Full record

ReviewRNA biology2024

Therapeutic potential of natural antisense transcripts and various mechanisms involved for clinical applications and disease prevention.

Ashiq Ali, Aisha Khatoon, Chenran Shao, Bilal Murtaza, Qaisar Tanveer, Zhongjing Su

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in RNA biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 3 countries.

Ashiq AliDepartment of Histology and Embryology, Shantou University Medical College, Shantou, China.
Aisha KhatoonDepartment of Pathology, University of Agriculture Faisalabad, Faisalabad, Pakistan.
Chenran ShaoDepartment of Histology and Embryology, Shantou University Medical College, Shantou, China.
Bilal MurtazaSchool of Bioengineering, Dalian University of Technology, Dalian, China.
Qaisar TanveerThe Roslin Institute, The Royal (Dick) School of Veterinary Studies, The University of Edinburgh, Edinburgh, UK.
Zhongjing SuDepartment of Histology and Embryology, Shantou University Medical College, Shantou, China.
Shantou University · CNDalian University of Technology · CNShantou University Medical College · CNUniversity of Agriculture Faisalabad · PKUniversity of Edinburgh · GB

Funding

National Natural Science Foundation of China (NSFC) 31870745
6 · The paper itself

Abstract

Antisense transcription, a prevalent occurrence in mammalian genomes, gives rise to natural antisense transcripts (NATs) as RNA molecules. These NATs serve as agents of diverse transcriptional and post-transcriptional regulatory mechanisms, playing crucial roles in various biological processes vital for cell function and immune response. However, when their normal functions are disrupted, they can contribute to human diseases. This comprehensive review aims to establish the molecular foundation linking NATs to the development of disorders like cancer, neurodegenerative conditions, and cardiovascular ailments. Additionally, we evaluate the potential of oligonucleotide-based therapies targeting NATs, presenting both their advantages and limitations, while also highlighting the latest advancements in this promising realm of clinical investigation.

Indexed as

Neurodegenerative DiseasesTranscription, GeneticAnimalsCell NucleusGene Expression RegulationHeterogeneous-Nuclear RibonucleoproteinsHumansMammalsPolypyrimidine Tract-Binding ProteinRNA, AntisenseUbiquitin ThiolesteraseHeterogeneous-Nuclear RibonucleoproteinsPolypyrimidine Tract-Binding ProteinPTBP1 protein, humanRNA, AntisenseUbiquitin ThiolesteraseUSP14 protein, humanclinical applicationshuman diseasesimmune responseNatural antisense transcriptsregulatory mechanisms

Identifiers

PMID38090817
PMCPMC10761088
OpenAlexW4389669991

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.