Evidence map›Paper›PMID 38090645›Full record

ArticleJournal of medical imaging (Bellingham, Wash.)2023

Quantitative perfusion and water transport time model from multi

Mira Liu, Niloufar Saadat, Yong Jeong, Steven Roth, Marek Niekrasz, Mihai Giurcanu, Timothy Carroll, Gregory Christoforidis

Abstract read
In one paragraph

Article in Journal of medical imaging (Bellingham, Wash.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Mira LiuUniversity of Chicago, Committee on Medical Physics, Department of Radiology, Chicago, Illinois, United States.ORCID https://orcid.org/0000-0002-8729-9302
Niloufar SaadatUniversity of Chicago, Committee on Medical Physics, Department of Radiology, Chicago, Illinois, United States.
Yong JeongUniversity of Chicago, Committee on Medical Physics, Department of Radiology, Chicago, Illinois, United States.
Steven RothUniversity of Illinois, Department of Anesthesiology, Chicago, Illinois, United States.
Marek NiekraszUniversity of Chicago, Committee on Medical Physics, Department of Radiology, Chicago, Illinois, United States.
Mihai GiurcanuUniversity of Chicago, Department of Statistics, Chicago, Illinois, United States.ORCID https://orcid.org/0000-0001-6058-3891
Timothy CarrollUniversity of Chicago, Committee on Medical Physics, Department of Radiology, Chicago, Illinois, United States.ORCID https://orcid.org/0000-0003-2113-6284
Gregory ChristoforidisUniversity of Chicago, Committee on Medical Physics, Department of Radiology, Chicago, Illinois, United States.

Funding

Development of Novel MR Imaging for Ischemic Stroke EvaluationR01NS093908 · NINDS · UNIVERSITY OF CHICAGO · PI CARROLL, TIMOTHY J, CHRISTOFORIDIS, GREGORY · 2015 to 2019
$2.6M
NINDS NIH HHS R01 NS093908
6 · The paper itself

Abstract

Purpose: Quantification of perfusion in ml/100 g/min, rather than comparing relative values side-to-side, is critical at the clinical and research levels for large longitudinal and multi-center trials. Intravoxel incoherent motion (IVIM) is a non-contrast magnetic resonance imaging diffusion-based scan that uses a multitude of Approach: We derive an expression for the quantification of capillary blood flow in ml/100 g/min by solving the three-dimensional Gaussian probability distribution and defining water transport time (WTT) as when 50% of the original water remains in the tissue of interest. Calculations were verified in a six-subject pre-clinical canine model of normocapnia, Results: Linear regression analysis of IVIM and microsphere perfusion showed agreement (slope = 0.55, intercept = 52.5, Conclusions: The accuracy and sensitivity of IVIM provides evidence that observed signal changes reflect cytotoxic edema and tissue perfusion and can be quantified with WTT. Partial volume contamination of CSF may be better removed during post-processing rather than with inversion recovery.

Indexed as

cerebrospinal fluiddiffusionmagnetic resonance imagingperfusionstroke

Identifiers

PMID38090645
PMCPMC10711680

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.