ArticleBrain communications2023
Clinical course of pathologically confirmed corticobasal degeneration and corticobasal syndrome.
Erratum issuedOpen access · goldAbstract read
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Article in Brain communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 25 papers.
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25citing papers in PubMed
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What it found
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Who cites it
25 citing papers in PubMed, 27 citations in OpenAlex.
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- Study protocol: double-blind, randomized, prospective, placebo controlled parallel group phase II study to investigate the effect of glycerol phenylbutyrate (GPB) on neurofilament light chain (NfL) levels in patients with corticobasal syndrome (CBS).Neurological research and practice · 2026Article
- Very-Late-Onset Corticobasal Degeneration Presenting as Behavioural Variant Frontotemporal Dementia: An Autopsy, Biochemical and Ultrastructural-Confirmed Case.Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society · 2026Article
- The Global Parkinson's Genetics Program (GP2): Advancing genetic discovery and capacity building worldwide.Journal of Parkinson's disease · 2026Review
- Progressive Supranuclear Palsy with Predominant Speech/Language Disorder.Internal medicine (Tokyo, Japan) · 2026Article
- Sex differences for clinical presentations and co-pathologies in four-repeat tauopathies.Biology of sex differences · 2026Article
- Early clinical characteristics of pathologically confirmed progressive supranuclear palsy and corticobasal degeneration.Journal of neurology · 2026Article
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- Cause of death for patients who present with primary progressive apraxia of speech.Parkinsonism & related disorders · 2025Article
- Corticobasal degeneration preceded by cognitive impairment and apathy: An autopsy case report.PCN reports : psychiatry and clinical neurosciences · 2025Article
- Parkinsonism in Alzheimer's disease without Lewy bodies in association with nigral neuron loss: A data-driven clinicopathologic study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
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- Conventional magnetic resonance imaging key features for distinguishing pathologically confirmed corticobasal degeneration from its mimics: a retrospective analysis of the J-VAC study.Neuroradiology · 2024Article
Corrections and comments
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- Erratum issued
Authors and funding
54 authors at 20 institutions in 2 countries.
Ikuko AibaDepartment of Neurology, NHO Higashinagoya National Hospital, Nagoya, Aichi 465-8620, Japan.
Yuichi HayashiDepartment of Neurology, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan.
Takayoshi ShimohataDepartment of Neurology, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan.
Mari YoshidaDepartment of Neuropathology, Institute for Medical Science of Aging, Aichi Medical University, Nagakute, Aichi 480-1195, Japan.
Yuko SaitoDepartment of Neuropathology (the Brain Bank for Aging Research), Tokyo Metropolitan Institute for Geriatrics and Gerontology, Itabashi, Tokyo 173-0015, Japan.
Koichi WakabayashiDepartment of Neuropathology, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori 036-8562, Japan.
Takashi KomoriDepartment of Laboratory Medicine and Pathology (Neuropathology), Tokyo Metropolitan Neurological Hospital, Fuchu, Tokyo 183-0042, Japan.
Masato HasegawaDepartment of Brain & Neurosciences, Tokyo Metropolitan Institute of Medical Science, Setagaya, Tokyo 156-8506, Japan.ORCID https://orcid.org/0000-0001-7415-8159
Takeshi IkeuchiDepartment of Molecular Genetics, Brain Research Institute, Niigata University, Chuo, Niigata 951-8585, Japan.ORCID https://orcid.org/0000-0001-8828-8085
Aya M TokumaruDepartment of Diagnostic Radiology, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Itabashi, Tokyo 173-0015, Japan.
Keita SakuraiDepartment of Radiology, National Center for Geriatrics and Gerontology, Obu, Aichi 474-8511, Japan.
Shigeo MurayamaBrain Bank for Neurodevelopmental, Neurological and Psychiatric Disorders, United Graduate School of Child Development, Osaka University, Suita, Osaka 565-0871, Japan.
Kazuko HasegawaDepartment of Neurology, NHO Sagamihara National Hospital, Sagamihara, Kanagawa 252-0392, Japan.
Toshiki UchiharaNeurology Clinic with Neuromorphomics Laboratory, Nitobe-Memorial Nakano General Hospital, Nakano, Tokyo 164-8607, Japan.
Yasuko ToyoshimaDepartment of Neurology, Brain Disease Center Agano Hospital, Agano, Niigata 959-2221, Japan.
Yufuko SaitoDepartment of Neurology, NHO Higashinagoya National Hospital, Nagoya, Aichi 465-8620, Japan.
Ichiro YabeDepartment of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido 060-8638, Japan.
Satoshi TanikawaInstitute for Chemical Reaction Design and Discovery (WPI-ICReDD), Hokkaido University, Sapporo, Hokkaido 001-0021, Japan.
Keizo SugayaDepartment of Neurology, Tokyo Metropolitan Neurological Hospital, Fuchu, Tokyo 183-0042, Japan.
Kentaro HayashiDepartment of Neurology, Tokyo Metropolitan Neurological Hospital, Fuchu, Tokyo 183-0042, Japan.
Terunori SanoDepartment of Laboratory Medicine, National Center Hospital, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187-8551, Japan.
Masaki TakaoDepartment of Laboratory Medicine, National Center Hospital, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187-8551, Japan.
Motoko SakaiDepartment of Neurology, NHO Suzuka National Hospital, Suzuka, Mie 513-8501, Japan.
Harutoshi FujimuraDepartment of Neurology, NHO Osaka Toneyama Medical Center, Toyonaka, Osaka 560-8552, Japan.
Hiroshi TakigawaDivision of Neurology, Department of Brain and Neurosciences, Faculty of Medicine, Tottori University, Yonago, Tottori 683-8503, Japan.
Tadashi AdachiDivision of Neuropathology, Department of Brain and Neurosciences, Faculty of Medicine, Tottori University, Yonago, Tottori 683-8503, Japan.
Ritsuko HanajimaDivision of Neurology, Department of Brain and Neurosciences, Faculty of Medicine, Tottori University, Yonago, Tottori 683-8503, Japan.
Osamu YokotaDepartment of Psychiatry, Kinoko Espoir Hospital, Kasaoka, Okayama 714-0071, Japan.
Tomoko MikiDepartment of Psychiatry, Kinoko Espoir Hospital, Kasaoka, Okayama 714-0071, Japan.
Yasushi IwasakiDepartment of Neuropathology, Institute for Medical Science of Aging, Aichi Medical University, Nagakute, Aichi 480-1195, Japan.
Michio KobayashiDepartment of Neurology, NHO Akita National Hospital, Yurihonjo, Akita 018-1393, Japan.
Nobutaka AraiLaboratory of Neuropathology, Tokyo Metropolitan Institute of Medical Science, Setagaya, Tokyo 156-8506, Japan.
Takuya OhkuboDepartment of Neurology and Neurological Sciences, Tokyo Medical and Dental University, Bunkyo, Tokyo 113-8519, Japan.
Takanori YokotaDepartment of Neurology and Neurological Sciences, Tokyo Medical and Dental University, Bunkyo, Tokyo 113-8519, Japan.
Keiko MoriDepartment of Neurology, Oyamada Memorial Spa Hospital, Yokkaichi, Mie 512-1111, Japan.
Masumi ItoDepartment of Neurology, Oyamada Memorial Spa Hospital, Yokkaichi, Mie 512-1111, Japan.
Chiho IshidaDepartment of Neurology, NHO Iou National Hospital, Kanazawa, Ishikawa 920-0192, Japan.
Masaharu TanakaDepartment of Psychiatry, Mishima Hospital, Nagaoka, Niigata 940-2302, Japan.
Jiro IdezukaDepartment of Neurology, Ojiya Sakura Hospital, Ojiya, Niigata 947-0041, Japan.
Masato KanazawaDepartment of Neurology, Clinical Neuroscience Branch, Brain Research Institute, Niigata University, Chuo, Niigata 951-8585, Japan.ORCID https://orcid.org/0000-0001-6337-8156
Kenju AokiDepartment of Neurology, Brain Disease Center Agano Hospital, Agano, Niigata 959-2221, Japan.
Masashi AokiDepartment of Neurology, Tohoku University Graduate School of Medicine, Sendai, Miyagi 980-8574, Japan.
Takafumi HasegawaDepartment of Neurology, Tohoku University Graduate School of Medicine, Sendai, Miyagi 980-8574, Japan.
Hirohisa WatanabeDepartment of Neurology, Fujita Health University School of Medicine, Toyoake, Aichi 470-1192, Japan.
Atsushi HashizumeDepartment of Clinical Research Education, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan.
Hisayoshi NiwaDepartment of Neurology, Kariya Toyota General Hospital, Kariya, Aichi 448-8505, Japan.
Keizo YasuiDepartment of Neurology, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, Nagoya, Aichi 466-8650, Japan.
Keita ItoDepartment of Neurology, Hekinan Municipal Hospital, Hekinan, Aichi 447-8502, Japan.
Yukihiko WashimiDepartment of Geriatrics and Gerontology, National Center for Geriatrics and Gerontology, Obu, Aichi 474-8511, Japan.
Eiichiro MukaiDepartment of Neurology, Aichi-pref Saiseikai Rehabilitation Hospital, Nagoya, Aichi 451-0052, Japan.
Akatsuki KubotaDepartment of Neurology, Graduate School of Medicine, The University of Tokyo, Bunkyo, Tokyo 113-8655, Japan.
Tatsushi TodaDepartment of Neurology, Graduate School of Medicine, The University of Tokyo, Bunkyo, Tokyo 113-8655, Japan.ORCID https://orcid.org/0000-0002-0717-1123
Kenji NakashimaDepartment of Neurology, NHO Matsue Medical Center, Matsue, Shimane 690-8556, Japan.
J-VAC study group
National Center of Neurology and Psychiatry · JPOkayama University · JPTokyo Medical and Dental University · JPHokkaido University · JPTokyo Metropolitan Institute of Medical Science · JPFujita Health University · JPNiigata University · JPTohoku University · JPTottori University · JPAichi Medical University · JPHigashi Nagoya National Hospital · JPNational Center for Geriatrics and Gerontology · JPTokyo Metropolitan Neurological Hospital · JPGifu University · JPHekinan Technical High School · JPHirosaki University · JPKariya Toyota General Hospital · JPNagoya Ekisaikai Hospital · JPNational Sagamihara Hospital · JPMinistry of Health Labour and Welfare · JP
Funding
No grant is acknowledged in the PubMed record.
Abstract
The clinical presentation of corticobasal degeneration is diverse, while the background pathology of corticobasal syndrome is also heterogeneous. Therefore, predicting the pathological background of corticobasal syndrome is extremely difficult. Herein, we investigated the clinical findings and course in patients with pathologically, genetically and biochemically verified corticobasal degeneration and corticobasal syndrome with background pathology to determine findings suggestive of background disorder. Thirty-two patients were identified as having corticobasal degeneration. The median intervals from the initial symptoms to the onset of key milestones were as follows: gait disturbance, 0.0 year; behavioural changes, 1.0 year; falls, 2.0 years; cognitive impairment, 2.0 years; speech impairment, 2.5 years; supranuclear gaze palsy, 3.0 years; urinary incontinence, 3.0 years; and dysphagia, 5.0 years. The median survival time was 7.0 years; 50% of corticobasal degeneration was diagnosed as corticobasal degeneration/corticobasal syndrome at the final presentation. Background pathologies of corticobasal syndrome (
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clinical coursecorticobasal degenerationcorticobasal syndromediagnosispathology
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