Evidence map›Paper›PMID 38090022›Full record

ArticleJournal of magnetic resonance open2023

Facile hyperpolarization chemistry for molecular imaging and metabolic tracking of [1-

Keilian MacCulloch, Austin Browning, David O Guarin Bedoya, Stephen J McBride, Mustapha B Abdulmojeed, Carlos Dedesma, Boyd M Goodson, Matthew S Rosen, Eduard Y Chekmenev, Yi-Fen Yen and 2 more

Abstract read
In one paragraph

Article in Journal of magnetic resonance open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Biocompatible SABRE Hyperpolarization of [1-Chemistry (Weinheim an der Bergstrasse, Germany) · 2026
    Article
  5. High-resolution microtesla in-situJournal of magnetic resonance (San Diego, Calif. : 1997) · 2026
    Article
  6. Article
  7. Hyperpolarization of [1-Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  8. Multidimensional pH-Temperature Mapping of SABRE-SHEATHThe journal of physical chemistry. B · 2025
    Article
  9. Article
  10. EfficientJournal of magnetic resonance open · 2025
    Article
  11. Scalable Hyperpolarized MRI Enabled by Ace-SABRE of [1-Angewandte Chemie (International ed. in English) · 2025
    Article
  12. SABRE-SHEATH hyperpolarizedChemical communications (Cambridge, England) · 2025
    Article
  13. Review
  14. Article
  15. Quo Vadis HyperpolarizedZeitschrift fur medizinische Physik · 2025
    Review
  16. Article
  17. Theranostics · 2025
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Keilian MacCullochDepartment of Chemistry, North Carolina State University, Raleigh, NC, 27695,USA.
Austin BrowningDepartment of Chemistry, North Carolina State University, Raleigh, NC, 27695,USA.
David O Guarin BedoyaDepartment of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA.
Stephen J McBrideDepartment of Chemistry, North Carolina State University, Raleigh, NC, 27695,USA.
Mustapha B AbdulmojeedDepartment of Chemistry, North Carolina State University, Raleigh, NC, 27695,USA.
Carlos DedesmaVizma Life Sciences Inc., Chapel Hill, NC, 27514, United States.
Boyd M GoodsonSchool of Chemical & Biomolecular Sciences and Materials Technology Center, Southern Illinois University, Carbondale, IL, 62901, USA.
Matthew S RosenDepartment of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA.
Eduard Y ChekmenevDepartment of Chemistry, Integrative Bio-sciences (Ibio), Karmanos Cancer Institute (KCI), Wayne State University, Detroit, MI 48202, USA.
Yi-Fen YenDepartment of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA.
Patrick TomHonVizma Life Sciences Inc., Chapel Hill, NC, 27514, United States.
Thomas TheisDepartment of Chemistry, North Carolina State University, Raleigh, NC, 27695,USA.

Funding

Carbon-13 Polarizer for Metabolic MR ImagingS10OD021768 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI YEN, YI-FEN · 2017 to 2017
$1.9M
Molecular MRI of Brain Metabolism Enabled by Long-Lived Spin StatesR01EB029829 · NIBIB · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI THEIS, THOMAS · 2020 to 2020
$807k
A Proof-of-concept of Vitamin B3 for Metabolic MR ImagingR21GM137227 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI YEN, YI-FEN · 2020 to 2021
$461k
NIBIB NIH HHS R01 EB029829NIGMS NIH HHS R21 GM137227NIH HHS S10 OD021768
6 · The paper itself

Abstract

Hyperpolarization chemistry based on reversible exchange of parahydrogen, also known as Signal Amplification By Reversible Exchange (SABRE), is a particularly simple approach to attain high levels of nuclear spin hyperpolarization, which can enhance NMR and MRI signals by many orders of magnitude. SABRE has received significant attention in the scientific community since its inception because of its relative experimental simplicity and its broad applicability to a wide range of molecules, however in vivo detection of molecular probes hyperpolarized by SABRE has remained elusive. Here we describe a first demonstration of SABRE-hyperpolarized contrast detected in vivo, specifically using hyperpolarized [1-

Identifiers

PMID38090022
PMCPMC10715622

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.