Evidence map›Paper›PMID 38089915›Full record

ArticlePeerJ2023

Hematopoietic effect of echinochrome on phenylhydrazine-induced hemolytic anemia in rats.

Mona S E F El-Shehry, Rafa A Amrymi, Tarek Atia, Bassant M M Lotfy, Salma H A Ahmed, Sarah A Qutb, Sara B Ali, Ayman S Mohamed, Mohamed R Mousa, Ahmed A Damanhory and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 3 countries.

Mona S E F El-ShehryBiotechnology Department, Faculty of Biotechnology-October University for Modern Sciences and Arts (MSA), Cairo, Egypt.
Rafa A AmrymiDepartment of Zoology, Faculty of Arts and Sciences, Alabyar University of Benghazi, Benghazi, Libya.
Tarek AtiaDepartment of Medical Laboratory, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al-Kharj, Saudi Arabia.ORCID 0000-0001-8236-5051
Bassant M M LotfyBiotechnology Department, Faculty of Biotechnology-October University for Modern Sciences and Arts (MSA), Cairo, Egypt.
Salma H A AhmedBiotechnology Department, Faculty of Biotechnology-October University for Modern Sciences and Arts (MSA), Cairo, Egypt.
Sarah A QutbZoology Department, Faculty of Science-Cairo University, Cairo, Egypt.
Sara B AliZoology Department, Faculty of Science-Cairo University, Cairo, Egypt.
Ayman S MohamedZoology Department, Faculty of Science-Cairo University, Cairo, Egypt.
Mohamed R MousaDepartment of Pathology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.
Ahmed A DamanhoryDepartment of Biochemistry, General Medicine Practice Program, Batterjee Medical College, Jeddah, Saudi Arabia.
Mostafa E MetaweeDepartment of Histology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Hader I SakrDepartment of Medical Physiology, Faculty of Medicine, Cairo University, Cairo, Egypt.ORCID 0000-0003-2917-2423
Cairo University · EGOctober University of Modern Sciences and Arts · EGAl-Azhar University · EGPrince Sattam Bin Abdulaziz University · SAUniversity of Benghazi · LY

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Hemolytic anemia (HA) is a serious health condition resulting from reduced erythrocytes' average life span. Echinochrome (Ech) is a dark-red pigment found in shells and spines of sea urchins. Aim: Studying the potential therapeutic effect of Ech on phenylhydrazine (PHZ)-induced HA in rats. Methods: Eighteen rats were divided into three groups ( Results: Ech resulted in a considerable increase in RBCs, WBCs, and platelets counts, hemoglobin, reduced glutathione, catalase, and glutathione-S-transferase levels, and a significant decrease in aspartate & alanine aminotransferases, alkaline phosphatase, gamma-glutamyl transferase, bilirubin, creatinine, urea, urate, malondialdehyde & nitric oxide levels in anemic rats. Histopathological examination of liver and kidney tissue samples showed marked improvement. Conclusion: Ech ameliorated phenylhydrazine-induced HA with a hepatorenal protective effect owing to its anti-inflammatory and antioxidant properties.

Indexed as

Anemia, HemolyticOxidative StressAnimalsAntioxidantsgamma-GlutamyltransferaseGlutathione TransferasePhenylhydrazinesRatsAntioxidantsgamma-GlutamyltransferaseGlutathione TransferasePhenylhydrazinesEchinochromeHemolytic AnemiaOxidative stressPhenylhydrazine

Identifiers

PMID38089915
PMCPMC10712303
OpenAlexW4389482662

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.