ArticleFrontiers in cellular and infection microbiology2023
The relationship between gut microbiota and insomnia: a bi-directional two-sample Mendelian randomization research.
Article in Frontiers in cellular and infection microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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Who cites it
24 citing papers in PubMed, 30 citations in OpenAlex.
- Causal links between gut microbiota, plasma metabolites, and insomnia: Insights from Mendelian randomization.Dialogues in clinical neuroscience · 2026Article
- Review
- The Gut Microbiome in Sleep Disorders: A Review of Recent Evidence.Actas espanolas de psiquiatria · 2026Review
- Gut Microbiota-Immune-Inflammation Axis as a Putative Pathogenic Axis in Chronic Insomnia: Mechanistic Dissection of NLRP3 Inflammasome and NF-κB Signaling.International journal of general medicine · 2026Review
- Study on diagnostic models for insomnia and gastralgia with Liver-Spleen Disharmony Syndrome based on machine learning.Frontiers in medicine · 2026Article
- Beyond the 'second brain': the gut microbiota as a constitutive co-constructor of embodied cognitive network.Frontiers in neuroscience · 2026Review
- Gut Microbiota, Immune Phenotypes, and Insomnia: A Two-Sample Mendelian Randomization Study.Nature and science of sleep · 2026Article
- Heterogeneity in the association between gut microbiota and insomnia moderated by Parkinson's disease status.Frontiers in cellular and infection microbiology · 2026Article
- Sex hormones and functional gastrointestinal disorders in menopausal women.Frontiers in endocrinology · 2026Review
- Sleep Disorders in Climacteric Women: Glutathione, Glutathione S-Transferase P1 and Gut Microbiome Interrelation.Pathophysiology : the official journal of the International Society for Pathophysiology · 2025Article
- Gut Microbiota Influences Meningioma Pathogenesis via Circulating Metabolites: A Two-Sample Mendelian Randomization Study.Brain and behavior · 2025Article
- Identification of core gene-gut microbiome associations in diverticulitis patients through a two-sample mendelian randomization and bioinformatics-based investigation.Global medical genetics · 2025Article
- Biotin Supplementation-The Cause of Hypersensitivity and Significant Interference in Allergy Diagnostics.Nutrients · 2025Review
- Sleep duration associated with altered oral microbiome diversity and composition in the NIH AARP cohort.Sleep advances : a journal of the Sleep Research Society · 2025Article
- The Bidirectional Relationship Between the Gut Microbiome and Mental Health: A Comprehensive Review.Cureus · 2025Review
- Association between breast cancer risk factors and blood microbiome in patients with breast cancer.Scientific reports · 2025Article
- Gut-X axis.iMeta · 2025Review
- Association between dietary index for gut microbiota and sleep duration in US adults: a cross-sectional study.Current research in microbial sciences · 2025Article
- Mendelian randomization studies on the causal relationship between insomnia and disease.Frontiers in medicine · 2025Review
- Investigating bidirectional causal relationships between gut microbiota and insomnia.General psychiatry · 2025Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Insomnia is the second most common mental health issue, also is a social and financial burden. Insomnia affects the balance between sleep, the immune system, and the central nervous system, which may raise the risk of different systemic disorders. The gut microbiota, referred to as the "second genome," has the ability to control host homeostasis. It has been discovered that disruption of the gut-brain axis is linked to insomnia. Methods: In this study, we conducted MR analysis between large-scale GWAS data of GMs and insomnia to uncover potential associations. Results: Ten GM taxa were detected to have causal associations with insomnia. Among them, class Conclusion: It suggested that the relationship between insomnia and intestinal flora was convoluted. Our findings may offer beneficial biomarkers for disease development and prospective candidate treatment targets for insomnia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.