Optimal control analysis of a transmission interruption model for the soil-transmitted helminth infections in Kenya.

Collins Okoyo, Idah Orowe, Nelson Onyango, Antonio Montresor, Charles Mwandawiro, Graham F Medley

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Article in Current research in parasitology & vector-borne diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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6 authors.

Collins OkoyoSchool of Mathematics, University of Nairobi, Nairobi, Kenya.

Idah OroweSchool of Mathematics, University of Nairobi, Nairobi, Kenya.

Nelson OnyangoSchool of Mathematics, University of Nairobi, Nairobi, Kenya.

Antonio MontresorDepartment of Control of Neglected Tropical Diseases, World Health Organization, Geneva, Switzerland.

Charles MwandawiroEastern and Southern Africa Centre of International Parasite Control (ESACIPAC), Kenya Medical Research Institute (KEMRI), Nairobi, Kenya.

Graham F MedleyFaculty of Public Health and Policy, London School of Hygiene and Tropical Medicine (LSHTM), London, United Kingdom.

Funding

World Health Organization 001

6 · The paper itself

Abstract

Kenya is among the countries endemic for soil-transmitted helminthiasis (STH) with over 66 subcounties and over 6 million individuals being at-risk of infection. Currently, the country is implementing mass drug administration (MDA) to all the at-risk groups as the mainstay control strategy. This study aimed to develop and analyze an optimal control (OC) model, from a transmission interruption model, to obtain an optimal control strategy from a mix of three strategies evaluated. The study used the Pontryagin's maximum principle to solve, numerically, the OC model. The analysis results clearly demonstrated that water and sanitation when implemented together with the MDA programme offer the best chances of eliminating these tenacious and damaging parasites. Thus, we advocate for optimal implementation of the combined mix of the two interventions in order to achieve STH elimination in Kenya, and globally, in a short implementation period of less than eight years.

Indexed as

KenyaMathematical modelNeglected tropical diseasesOptimal controlSoil-transmitted helminthiasis

Identifiers

PMID38089690

DOI10.1016/j.crpvbd.2023.100162

PMCPMC10714213

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LicenceCC BY-NC-ND

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