Evidence map›Paper›PMID 38089552›Full record

ArticleJHEP reports : innovation in hepatology2024

Fine mapping identifies independent HLA associations in autoimmune hepatitis type 1.

You Li, Lu Zhou, Zuxiong Huang, Yue Yang, Jiming Zhang, Ling Yang, Yun Xu, Junping Shi, Shanhong Tang, Xiaoling Yuan and 24 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JHEP reports : innovation in hepatology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. [Role of HLA genetic variants in autoimmune diseases].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026
    Review
  3. Article
  4. [Diagnosis and treatment strategies of autoimmune hepatitis and future challenges].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2025
    Review
  5. Review
  6. Review
  7. Genetic and Genomic Approaches to the Study of Drug-Induced Liver Injury.Liver international : official journal of the International Association for the Study of the Liver · 2025
    Review
  8. Review
  9. Review
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors at 13 institutions in 2 countries.

You LiDivision of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, State Key Laboratory for Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease, Shanghai, China.
Lu ZhouDepartment of Gastroenterology and Hepatology, General Hospital, Tianjin Medical University, Tianjin, China.
Zuxiong HuangDepartment of Hepatology, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, China.
Yue YangDepartment of Dermatology, China-Japan Friendship Hospital, Beijing, China.
Jiming ZhangDepartment of Infectious Diseases, Huashan Hospital and Key Laboratory of Medical Molecular Virology (MOH & MOE), Shanghai Medical College, Fudan University, Shanghai, China.
Ling YangDivision of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Yun XuDepartment of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Junping ShiDepartment of Infectious disease and Hepatology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, China.
Shanhong TangDepartment of Gastroenterology, The General Hospital of Western Theater Command, Chengdu, China.
Xiaoling YuanDepartment of Infectious Disease, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jie XuDepartment of Infectious Disease, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yiling LiDepartment of Gastroenterology, First Affiliated Hospital of China Medical University, Shenyang, China.
Xu HanTianjin Second People's Hospital, Tianjin Institute of Hepatology, Tianjin, China.
Jia LiTianjin Second People's Hospital, Tianjin Institute of Hepatology, Tianjin, China.
Yanmin LiuClinical Laboratory Center and Clinical Research Center for Autoimmune Liver Disease, Beijing Youan Hospital, Capital Medical University, Beijing, China.
Ying SunSenior Department of Hepatology, the Fifth Medical Center of PLA General Hospital, Beijing, China.
Xiaozhi JinDepartment of Infectious Diseases, The First Affiliated Hospital of Wenzhou Medical University, Hepatology Institute of Wenzhou Medical University, Zhejiang Provincial Key Laboratory for Accurate Diagnosis and Treatment of Chronic Liver Diseases, Wenzhou, China.
Xiao XiaoDivision of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, State Key Laboratory for Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease, Shanghai, China.
Bangmao WangDepartment of Gastroenterology and Hepatology, General Hospital, Tianjin Medical University, Tianjin, China.
Qiuxiang LinDepartment of Hepatology, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, China.
Yang ZhouDepartment of Hepatology, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, China.
Xuejiao SongDepartment of Dermatology, China-Japan Friendship Hospital, Beijing, China.
Yong CuiDepartment of Dermatology, China-Japan Friendship Hospital, Beijing, China.
Lilin HuDivision of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Yuhu SongDivision of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Jie BaoDepartment of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Ling GongDepartment of Infectious disease and Hepatology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, China.
M Eric GershwinDivision of Rheumatology, Department of Medicine, Allergy and Clinical Immunology, University of California at Davis, Davis, CA, USA.
Xianbo ZuoDepartment of Dermatology, China-Japan Friendship Hospital, Beijing, China.
Huiping YanClinical Laboratory Center and Clinical Research Center for Autoimmune Liver Disease, Beijing Youan Hospital, Capital Medical University, Beijing, China.
Zhengsheng ZouSenior Department of Hepatology, the Fifth Medical Center of PLA General Hospital, Beijing, China.
Ruqi TangDivision of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, State Key Laboratory for Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease, Shanghai, China.
Xiong MaDivision of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, State Key Laboratory for Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease, Shanghai, China.
Chinese AIH Consortium
Shanghai Jiao Tong University · CNChina-Japan Friendship Hospital · CNFujian Medical University · CNUnion Hospital · CNAffiliated Hospital of Hangzhou Normal University · CNCapital Medical University · CNChinese PLA General Hospital · CNFirst Affiliated Hospital of Zhengzhou University · CNTianjin Medical University General Hospital · CNTianjin People's Hospital · CNFudan University · CNUniversity of California, Davis · USWenzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background & Aims: Association studies have greatly refined the important role of the major histocompatibility complex (MHC) region in autoimmune hepatitis (AIH). However, the effects of human leucocyte antigen (HLA) polymorphisms on AIH are not well established. The aim of this study is to systematically characterise the association of MHC variants with AIH in our well-defined cohort of patients. Methods: We performed an imputation-based analysis on the extensive association observed within the MHC region using the Han-MHC reference panel, and tested the comprehensive associations of HLA polymorphisms with AIH in 1622 Chinese AIH type 1 patients and 10,466 population controls. Results: A total of 588 HLA variants were significantly associated with AIH, with HLA-B∗35:01 ( Conclusions: Our study reveals three novel and independent variants at HLA-B∗35:01, HLA-B∗08:01, and rs7765379 associated with AIH across the whole MHC region in the Han Chinese population. The findings illustrate the value of the MHC region in AIH and provide a new perspective for the immunogenetics of AIH. Impact and implications: This study revealed three novel and independent variants associated with autoimmune hepatitis across the whole major histocompatibility complex region in the Han Chinese population. These findings are significant in identifying autoantigens, providing insights into the activation of the autoimmune processes, and further advancing our understanding of the immunogenetic basis underlying autoimmune hepatitis.

Indexed as

Autoimmune hepatitisHLA-B∗35:01Human leucocyte antigen

Identifiers

PMID38089552
PMCPMC10711477
OpenAlexW4387364234

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.