Evidence map›Paper›PMID 38089468›Full record

ReviewComputational and structural biotechnology journal2024

A holistic approach to understanding immune-mediated inflammatory diseases: bioinformatic tools to integrate omics data.

Gonzalo Borrego-Yaniz, Laura C Terrón-Camero, Martin Kerick, Eduardo Andrés-León, Javier Martin

Abstract readReview
In one paragraph

Review in Computational and structural biotechnology journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Gonzalo Borrego-YanizGenetic Basis of Autoimmune Diseases Group, Institute of Parasitology and Biomedicine López-Neyra (IPBLN), CSIC, Granada, Spain.
Laura C Terrón-CameroBioinformatics Unit, Institute of Parasitology and Biomedicine López-Neyra (IPBLN), CSIC, Granada, Spain.
Martin KerickGenetic Basis of Autoimmune Diseases Group, Institute of Parasitology and Biomedicine López-Neyra (IPBLN), CSIC, Granada, Spain.
Eduardo Andrés-LeónBioinformatics Unit, Institute of Parasitology and Biomedicine López-Neyra (IPBLN), CSIC, Granada, Spain.
Javier MartinGenetic Basis of Autoimmune Diseases Group, Institute of Parasitology and Biomedicine López-Neyra (IPBLN), CSIC, Granada, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immune-mediated inflammatory diseases (IMIDs) comprise a complex group of pathologies with diverse etiologies and clinical manifestations. In particular, omics technologies have remodeled our understanding of a set of IMIDs such as systemic autoimmune rheumatic diseases (SARDs), generating vast amounts of data on the genome, epigenome, transcriptome, proteome and metabolome of immune cells and SARDs patients. However, the integration of omics data to advance our knowledge of these diseases is challenging, requiring advanced bioinformatic tools. This review explores different multi-omic integrative tools for refining previous research, exploring the biological relevance of datasets within different contexts, or translating omics results into clinical advances. We also discuss relevant multi-omic studies in SARDs research and the potential of omics data from available repositories to complement ongoing investigation in this field.

Indexed as

BioinformaticsImmune-mediated inflammatory diseasesIntegrationOmics

Identifiers

PMID38089468
PMCPMC10714331

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.