Evidence map›Paper›PMID 38089441›Full record

ArticleKidney diseases (Basel, Switzerland)2023

Segmental Membranous Glomerulopathy in Adults.

Shuangshuang Zhu, Xiaoting Liu, Shuling Yue, Bei Luo, Zhen Song, Xiaomeng Xu, Lin Wang, Xiaotao Hou, Kongshan Li, Qiming Liang and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Kidney diseases (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. A membranous nephropathy variant mimicking minimal change disease.The journal of pathology. Clinical research · 2026
    Article
  2. Article
  3. Questions and Caveats in Antigen-Defined Membranous Nephropathy.Journal of the American Society of Nephrology : JASN · 2025
    Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Shuangshuang ZhuDepartment of Laboratory Medicine, Southern Medical University, Nanfang Hospital, Guangzhou, China.
Xiaoting LiuDepartment of Renal Pathology, King Medical Diagnostics Center, Guangzhou, China.
Shuling YueDepartment of Renal Pathology, King Medical Diagnostics Center, Guangzhou, China.
Bei LuoDepartment of Renal Pathology, King Medical Diagnostics Center, Guangzhou, China.
Zhen SongDepartment of Anorectal Surgery, Guangzhou Medical University, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Xiaomeng XuDepartment of Translational Medicine Center, Huaihe Hospital of Henan University, Kaifeng, China.
Lin WangDepartment of Renal Pathology, King Medical Diagnostics Center, Guangzhou, China.
Xiaotao HouDepartment of Renal Pathology, King Medical Diagnostics Center, Guangzhou, China.
Kongshan LiDepartment of Renal Pathology, King Medical Diagnostics Center, Guangzhou, China.
Qiming LiangDepartment of Renal Pathology, King Medical Diagnostics Center, Guangzhou, China.
Zheya ZhouDepartment of Renal Pathology, King Medical Diagnostics Center, Guangzhou, China.
Wenfang ChenDepartment of Pathology, Sun Yat-sen University, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Lei ZhengDepartment of Laboratory Medicine, Southern Medical University, Nanfang Hospital, Guangzhou, China.
Kingmed Diagnostics · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The clinicopathological features of segmental membranous glomerulopathy (SMGN) have not been well characterized. The aim of this study was to investigate the prevalence and clinicopathological features of SMGN in adults. Methods: Adult patients with biopsy-confirmed SMGN in the native kidney at our center between January 2017 to September 2020 were identified. The clinicopathological features of SMGN were collected. The glomerular deposition of IgG subclasses, M-type phospholipase A2 receptor 1 (PLA2R), thrombospondin type 1 domain-containing 7A (THSD7A), and neural epidermal growth factor-like 1 protein (NELL1) were tested. Clinical and pathologic features were comparable between NELL1-positive and NELL1-negative SMGN. Results: A total of 167 patients with biopsy-proven SMGN were enrolled. During the same period, 32,640 (33.0%) out of 98,939 renal biopsies were diagnosed with membranous nephropathy (MN) in adults. SMGN accounted for 0.17% of total kidney biopsies and 0.51% of MN in adults. One hundred and fifty (89.8%) cases were isolated SMGN, and 17 (10.2%) cases were complicated with other kidney disease. Clinically, the median age of isolated SMGN patients was 41.5 years, with female (74%) predominance, and 33.1% had full nephrotic syndrome. Pathologically, IgG1 was the dominant subclass (92.5%), followed by IgG4 (45.0%). PLA2R and THSD7A staining were done in 142 and 136 isolated SMGN cases, respectively, in which, all the cases showed negative. NELL1 staining was done in 135 isolated SMGN cases; 58 cases (43.0%) showed positive. Fifty-eight patients (41.1%) had diffuse (≥90%) foot process effacement, and 119 patients (83.8%) had either stage I (38.0%) or stage II (45.8%) membranous alterations in patients with SMGN. Most patients with NELL1-positive SMGN were female. Patients with NELL1-positive SMGN were more likely with lower prevalence of full nephrotic syndrome than NELL1-negative SMGN. Conclusions: SMGN is a relatively rare pathological type. Majority of patients with isolated SMGN were female, with a median age of 41.5 years, 33.1% had full nephrotic syndrome, absence of PLA2R and THSD7A, 43.0% with NELL1-positive, and mainly stage I or II MN (83.8%). NELL1 is the major target antigen of SMGN in adults.

Indexed as

Clinicopathological featuresM-type phospholipase A2 receptor 1Neural epidermal growth factor-like 1 proteinSegmental membranous glomerulopathyThrombospondin type 1 domain-containing 7A

Identifiers

PMID38089441
PMCPMC10712984
OpenAlexW4385651586

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.